KEGG   DRUG: CariprazineHelp
Entry
D09997                      Drug                                   

Name
Cariprazine (USAN/INN)
Formula
C21H32Cl2N4O
Exact mass
426.1953
Mol weight
427.411
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
  DG01475  Dopamine D3-receptor antagonist
Enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: N05AX15
Chemical structure group: DG01305
Product (DG01305): D09876<US>
Efficacy
Antipsychotic, Dopamine receptor partial agonist, Serotonin receptor partial agonist/antagonist
Target
DRD2 [HSA:1813] [KO:K04145]
HTR1A [HSA:3350] [KO:K04153]
HTR2A [HSA:3356] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX15 Cariprazine
      D09997  Cariprazine (USAN/INN)
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Cariprazine
    D09997  Cariprazine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D09997  Cariprazine (USAN/INN)
   Serotonin
    HTR1A
     D09997  Cariprazine (USAN/INN)
    HTR2A
     D09997  Cariprazine (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09997
BRITE hierarchy
Other DBs
CAS: 839712-12-8
PubChem: 135626718
ChEBI: 90933
ChEMBL: CHEMBL2028019
LigandBox: D09997
LinkDB All DBs
KCF data Show

ATOM        28
            1   C1x C    20.7900  -19.3900
            2   C1y C    20.7900  -17.9900
            3   C1x C    22.0500  -17.2900
            4   C1x C    23.2400  -17.9900
            5   C1y C    23.2400  -19.3900
            6   C1x C    22.0500  -20.0900
            7   C1b C    24.5000  -20.0900
            8   C1b C    25.6900  -19.3900
            9   N1y N    26.8800  -20.0900
            10  C1x C    28.0700  -19.3900
            11  C1x C    29.2600  -20.0900
            12  N1y N    29.2600  -21.4900
            13  C1x C    28.0700  -22.1900
            14  C1x C    26.8800  -21.4900
            15  C8y C    30.5200  -22.2600
            16  C8y C    31.7100  -21.5600
            17  C8y C    32.9700  -22.2600
            18  C8x C    32.9700  -23.6600
            19  C8x C    31.7100  -24.3600
            20  C8x C    30.5200  -23.6600
            21  X   Cl   34.1600  -21.4900
            22  X   Cl   31.7100  -20.0900
            23  N1b N    19.6000  -17.2900
            24  C5a C    18.4100  -17.9900
            25  N1c N    17.2200  -17.2900
            26  O5a O    18.4100  -19.3900
            27  C1a C    16.0300  -17.9900
            28  C1a C    17.2200  -15.8900
BOND        30
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    9  14 1
            16   12  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   17  21 1
            24   16  22 1
            25    2  23 1 #Up
            26   23  24 1
            27   24  25 1
            28   24  26 2
            29   25  27 1
            30   25  28 1

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