KEGG   DRUG: CabozantinibHelp
Entry
D10062                      Drug                                   

Name
Cabozantinib (USAN);
Cabometyx (TN);
Cometriq (TN)
Formula
C28H24FN3O5
Exact mass
501.17
Mol weight
501.5057
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
ATC code: L01XE26
Chemical structure group: DG01670
Product (DG01670): D10095<US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Comment
Treatment of medullary thyroid carcinoma
Target
RET [HSA:5979] [KO:K05126]
MET [HSA:4233] [KO:K05099]
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
NTRK2 (TRKB) [HSA:4915] [KO:K04360]
FLT3 (CD135) [HSA:2322] [KO:K05092]
AXL [HSA:558] [KO:K05115]
ROS1 [HSA:6098] [KO:K05088]
TYRO3 [HSA:7301] [KO:K05116]
MERTK [HSA:10461] [KO:K05117]
TEK (TIE2, CD202) [HSA:7010] [KO:K05121]
  Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE26 Cabozantinib
      D10062  Cabozantinib (USAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    ROS1
     D10062  Cabozantinib (USAN)
   PDGFR family
    KIT (CD117)
     D10062  Cabozantinib (USAN)
    FLT3 (CD135)
     D10062  Cabozantinib (USAN)
   VEGFR family
    VEGFR1 (FLT1)
     D10062  Cabozantinib (USAN)
    VEGFR2 (KDR)
     D10062  Cabozantinib (USAN)
    VEGFR3 (FLT4)
     D10062  Cabozantinib (USAN)
   MET family
    MET
     D10062  Cabozantinib (USAN)
   TRK family
    NTRK2 (TRKB)
     D10062  Cabozantinib (USAN)
   AXL family
    AXL
     D10062  Cabozantinib (USAN)
    TYRO3
     D10062  Cabozantinib (USAN)
    MERTK
     D10062  Cabozantinib (USAN)
   TIE family
    TEK (TIE2, CD202)
     D10062  Cabozantinib (USAN)
   RET family
    RET
     D10062  Cabozantinib (USAN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10062
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10062
BRITE hierarchy
Other DBs
CAS: 849217-68-1
PubChem: 135626782
ChEBI: 72317
ChEMBL: CHEMBL2105717
LigandBox: D10062
LinkDB All DBs
KCF data Show

ATOM        37
            1   C8y C    16.3800  -12.0400
            2   C8y C    16.3800  -13.4400
            3   C8y C    15.1900  -14.1400
            4   C8x C    13.9300  -13.4400
            5   C8x C    13.9300  -12.0400
            6   N5x N    15.1900  -11.3400
            7   C8x C    17.5700  -11.3400
            8   C8y C    18.8300  -12.0400
            9   C8y C    18.8300  -13.4400
            10  C8x C    17.5700  -14.1400
            11  O2a O    20.0200  -11.3400
            12  C1a C    21.2100  -12.0400
            13  O2a O    20.0200  -14.1400
            14  C1a C    21.2100  -13.4400
            15  O2a O    15.1900  -15.5400
            16  C8y C    16.4500  -16.2400
            17  C8x C    16.4500  -17.6400
            18  C8x C    17.6400  -18.3400
            19  C8y C    18.8300  -17.6400
            20  C8x C    18.8300  -16.1700
            21  C8x C    17.6400  -15.4700
            22  N1b N    20.0900  -18.2700
            23  C5a C    21.2800  -17.5700
            24  C1z C    22.5400  -18.2700
            25  O5a O    21.2800  -16.1700
            26  C5a C    23.7300  -17.5000
            27  N1b N    24.9200  -18.2000
            28  O5a O    23.7300  -16.1000
            29  C8y C    26.1100  -17.5000
            30  C8x C    27.3700  -18.2000
            31  C8x C    28.4900  -17.4300
            32  C8y C    28.4900  -16.0300
            33  C8x C    27.3000  -15.4000
            34  C8x C    26.1100  -16.1000
            35  X   F    29.7500  -15.4000
            36  C1x C    21.8400  -19.4600
            37  C1x C    23.2400  -19.4600
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    8  11 1
            13   11  12 1
            14    9  13 1
            15   13  14 1
            16    3  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   19  22 1
            25   22  23 1
            26   23  24 1
            27   23  25 2
            28   24  26 1
            29   26  27 1
            30   26  28 2
            31   27  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   32  33 1
            36   33  34 2
            37   29  34 1
            38   32  35 1
            39   36  37 1
            40   37  24 1
            41   24  36 1

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