Homo sapiens (human): 3791
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Entry
3791 CDS
T01001
Symbol
KDR, CD309, FLK1, VEGFR, VEGFR2
Name
(RefSeq) kinase insert domain receptor
KO
K05098
kinase insert domain protein receptor [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04370
VEGF signaling pathway
hsa04510
Focal adhesion
hsa05205
Proteoglycans in cancer
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06526
MAPK signaling
nt06528
Calcium signaling
nt06530
PI3K signaling
Element
N01592
GF-RTK-RAS-ERK signaling pathway
N01599
Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL
N01641
RTK-PLCG-ITPR signaling pathway
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
Disease
H01482
Infantile hemangioma
Drug target
Altiratinib:
D10862
Axitinib:
D03218
<JP/US>
Brivanib (
DG01373
):
D08878
D09589
Cabozantinib (
DG01670
):
D10062
D10095
<JP>
Catequentinib (
DG03258
):
D12526
D12537
Cediranib (
DG01360
):
D08881
D08883
Dovitinib lactate:
D08907
Foretinib:
D09618
Fruquintinib:
D11977
<JP/US>
Golvatinib (
DG01367
):
D10224
D10465
Lenvatinib (
DG01362
):
D09919
D09920
<JP/US>
Linifanib:
D09635
Lucitanib:
D11762
Midostaurin:
D05029
<US>
Motesanib (
DG01262
):
D06678
D08947
Nintedanib (
DG01374
):
D10396
<JP/US>
D10481
Pazopanib:
D05380
<JP/US>
Pegdinetanib:
D09945
Ramucirumab:
D09371
<JP/US>
Regorafenib (
DG00720
):
D10137
<JP/US>
D10138
Rivoceranib (
DG02966
):
D11288
D11289
Semaxanib:
D05819
Sitravatinib (
DG03045
):
D11140
D11541
Sorafenib (
DG00713
):
D06272
<JP/US>
D08524
Sunitinib (
DG00712
):
D06402
<JP/US>
D08552
Surufatinib:
D11885
Tesevatinib (
DG03101
):
D11772
D11773
Tinengotinib:
D12545
Tivozanib (
DG01375
):
D09683
D10190
<US>
Toceranib (
DG01363
):
D08503
D08544
Vandetanib:
D06407
<JP/US>
Vatalanib:
D06285
Zanzalintinib (
DG03273
):
D12650
D12651
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
3791 (KDR)
04015 Rap1 signaling pathway
3791 (KDR)
04151 PI3K-Akt signaling pathway
3791 (KDR)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
3791 (KDR)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
3791 (KDR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
3791 (KDR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
3791 (KDR)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
hsa04090
]
3791 (KDR)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
3791 (KDR)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
VEGFR family [OT]
3791 (KDR)
CD molecules [BR:
hsa04090
]
Proteins
3791 (KDR)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
VEGFR1-3_N_Ig-like
Ig_3
I-set
Pkinase
ig
Ig_2
VEGFR-1-like_Ig-like
VEGFR-1-like_5th
VEGFR-2_TMD
V-set
C2-set_2
Ig_4
BppU_N
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
3791
NCBI-ProteinID:
NP_002244
OMIM:
191306
HGNC:
6307
Ensembl:
ENSG00000128052
UniProt:
P35968
Structure
PDB
PDBj
LinkDB
All DBs
Position
4:complement(55078481..55125595)
Genome browser
AA seq
1356 aa
AA seq
DB search
MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD
WLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQD
YRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWD
SKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGE
KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRS
DQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPP
EIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP
PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPY
PCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGE
RVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPT
PVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLT
VLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNR
NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWL
LLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPL
GRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVN
LLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLK
RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLA
SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDR
VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML
DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVS
CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDS
GMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYS
SEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
NT seq
4071 nt
NT seq
+upstream
nt +downstream
nt
atgcagagcaaggtgctgctggccgtcgccctgtggctctgcgtggagacccgggccgcc
tctgtgggtttgcctagtgtttctcttgatctgcccaggctcagcatacaaaaagacata
cttacaattaaggctaatacaactcttcaaattacttgcaggggacagagggacttggac
tggctttggcccaataatcagagtggcagtgagcaaagggtggaggtgactgagtgcagc
gatggcctcttctgtaagacactcacaattccaaaagtgatcggaaatgacactggagcc
tacaagtgcttctaccgggaaactgacttggcctcggtcatttatgtctatgttcaagat
tacagatctccatttattgcttctgttagtgaccaacatggagtcgtgtacattactgag
aacaaaaacaaaactgtggtgattccatgtctcgggtccatttcaaatctcaacgtgtca
ctttgtgcaagatacccagaaaagagatttgttcctgatggtaacagaatttcctgggac
agcaagaagggctttactattcccagctacatgatcagctatgctggcatggtcttctgt
gaagcaaaaattaatgatgaaagttaccagtctattatgtacatagttgtcgttgtaggg
tataggatttatgatgtggttctgagtccgtctcatggaattgaactatctgttggagaa
aagcttgtcttaaattgtacagcaagaactgaactaaatgtggggattgacttcaactgg
gaatacccttcttcgaagcatcagcataagaaacttgtaaaccgagacctaaaaacccag
tctgggagtgagatgaagaaatttttgagcaccttaactatagatggtgtaacccggagt
gaccaaggattgtacacctgtgcagcatccagtgggctgatgaccaagaagaacagcaca
tttgtcagggtccatgaaaaaccttttgttgcttttggaagtggcatggaatctctggtg
gaagccacggtgggggagcgtgtcagaatccctgcgaagtaccttggttacccaccccca
gaaataaaatggtataaaaatggaataccccttgagtccaatcacacaattaaagcgggg
catgtactgacgattatggaagtgagtgaaagagacacaggaaattacactgtcatcctt
accaatcccatttcaaaggagaagcagagccatgtggtctctctggttgtgtatgtccca
ccccagattggtgagaaatctctaatctctcctgtggattcctaccagtacggcaccact
caaacgctgacatgtacggtctatgccattcctcccccgcatcacatccactggtattgg
cagttggaggaagagtgcgccaacgagcccagccaagctgtctcagtgacaaacccatac
ccttgtgaagaatggagaagtgtggaggacttccagggaggaaataaaattgaagttaat
aaaaatcaatttgctctaattgaaggaaaaaacaaaactgtaagtacccttgttatccaa
gcggcaaatgtgtcagctttgtacaaatgtgaagcggtcaacaaagtcgggagaggagag
agggtgatctccttccacgtgaccaggggtcctgaaattactttgcaacctgacatgcag
cccactgagcaggagagcgtgtctttgtggtgcactgcagacagatctacgtttgagaac
ctcacatggtacaagcttggcccacagcctctgccaatccatgtgggagagttgcccaca
cctgtttgcaagaacttggatactctttggaaattgaatgccaccatgttctctaatagc
acaaatgacattttgatcatggagcttaagaatgcatccttgcaggaccaaggagactat
gtctgccttgctcaagacaggaagaccaagaaaagacattgcgtggtcaggcagctcaca
gtcctagagcgtgtggcacccacgatcacaggaaacctggagaatcagacgacaagtatt
ggggaaagcatcgaagtctcatgcacggcatctgggaatccccctccacagatcatgtgg
tttaaagataatgagacccttgtagaagactcaggcattgtattgaaggatgggaaccgg
aacctcactatccgcagagtgaggaaggaggacgaaggcctctacacctgccaggcatgc
agtgttcttggctgtgcaaaagtggaggcatttttcataatagaaggtgcccaggaaaag
acgaacttggaaatcattattctagtaggcacggcggtgattgccatgttcttctggcta
cttcttgtcatcatcctacggaccgttaagcgggccaatggaggggaactgaagacaggc
tacttgtccatcgtcatggatccagatgaactcccattggatgaacattgtgaacgactg
ccttatgatgccagcaaatgggaattccccagagaccggctgaagctaggtaagcctctt
ggccgtggtgcctttggccaagtgattgaagcagatgcctttggaattgacaagacagca
acttgcaggacagtagcagtcaaaatgttgaaagaaggagcaacacacagtgagcatcga
gctctcatgtctgaactcaagatcctcattcatattggtcaccatctcaatgtggtcaac
cttctaggtgcctgtaccaagccaggagggccactcatggtgattgtggaattctgcaaa
tttggaaacctgtccacttacctgaggagcaagagaaatgaatttgtcccctacaagacc
aaaggggcacgattccgtcaagggaaagactacgttggagcaatccctgtggatctgaaa
cggcgcttggacagcatcaccagtagccagagctcagccagctctggatttgtggaggag
aagtccctcagtgatgtagaagaagaggaagctcctgaagatctgtataaggacttcctg
accttggagcatctcatctgttacagcttccaagtggctaagggcatggagttcttggca
tcgcgaaagtgtatccacagggacctggcggcacgaaatatcctcttatcggagaagaac
gtggttaaaatctgtgactttggcttggcccgggatatttataaagatccagattatgtc
agaaaaggagatgctcgcctccctttgaaatggatggccccagaaacaatttttgacaga
gtgtacacaatccagagtgacgtctggtcttttggtgttttgctgtgggaaatattttcc
ttaggtgcttctccatatcctggggtaaagattgatgaagaattttgtaggcgattgaaa
gaaggaactagaatgagggcccctgattatactacaccagaaatgtaccagaccatgctg
gactgctggcacggggagcccagtcagagacccacgttttcagagttggtggaacatttg
ggaaatctcttgcaagctaatgctcagcaggatggcaaagactacattgttcttccgata
tcagagactttgagcatggaagaggattctggactctctctgcctacctcacctgtttcc
tgtatggaggaggaggaagtatgtgaccccaaattccattatgacaacacagcaggaatc
agtcagtatctgcagaacagtaagcgaaagagccggcctgtgagtgtaaaaacatttgaa
gatatcccgttagaagaaccagaagtaaaagtaatcccagatgacaaccagacggacagt
ggtatggttcttgcctcagaagagctgaaaactttggaagacagaaccaaattatctcca
tcttttggtggaatggtgcccagcaaaagcagggagtctgtggcatctgaaggctcaaac
cagacaagcggctaccagtccggatatcactccgatgacacagacaccaccgtgtactcc
agtgaggaagcagaacttttaaagctgatagagattggagtgcaaaccggtagcacagcc
cagattctccagcctgactcggggaccacactgagctctcctcctgtttaa
DBGET
integrated database retrieval system
