KEGG   DRUG: Dasolampanel
Entry
D10107                      Drug                                   
Name
Dasolampanel (USAN/INN)
Formula
C17H20ClN5O3
Exact mass
377.1255
Mol weight
377.82
Structure
Simcomp
Efficacy
Pain relief, AMPA receptor antagonist, Kainate receptor antagonist
Comment
Treatment of chronic pain
Target
GRIA [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200]
GRIK [HSA:2897 2898 2899 2900 2901] [KO:K05201 K05202 K05203 K05204 K05205]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), non-NMDA
    GRIA
     D10107  Dasolampanel (USAN/INN)
    GRIK
     D10107  Dasolampanel (USAN/INN)
Other DBs
CAS: 503294-13-1
PubChem: 135626825
ChEBI: 177544
PDB-CCD: SXI[PDBj]
LigandBox: D10107
LinkDB
KCF data

ATOM        26
            1   C1y C    20.3112  -21.8514
            2   N1x N    20.3112  -23.2522
            3   C1x C    21.5018  -23.9525
            4   C1y C    22.6925  -23.2522
            5   C1y C    22.6925  -21.8514
            6   C1x C    21.5018  -21.1510
            7   C1x C    23.9532  -23.9525
            8   C1x C    25.1438  -23.2522
            9   C1y C    25.1438  -21.8514
            10  C1x C    23.9532  -21.1510
            11  C6a C    19.0505  -21.1510
            12  O2a O    26.3345  -21.1510
            13  O6a O    17.8598  -21.7814
            14  O6a O    19.0505  -19.7502
            15  C8y C    27.5251  -21.8514
            16  C8x C    27.5251  -23.2522
            17  C8x C    28.7858  -23.9525
            18  C8x C    29.9765  -23.2522
            19  C8y C    29.9765  -21.8514
            20  C8y C    28.7858  -21.1510
            21  C8y C    28.7858  -19.7502
            22  X   Cl   31.1671  -21.1510
            23  N5x N    27.6652  -18.9798
            24  N4x N    29.9765  -18.9798
            25  N5x N    29.5562  -17.6491
            26  N5x N    28.0854  -17.6491
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    1  11 1 #Down
            13    9  12 1 #Up
            14   11  13 1
            15   11  14 2
            16   12  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23   20  21 1
            24   19  22 1
            25   23  21 2
            26   21  24 1
            27   24  25 1
            28   25  26 2
            29   23  26 1

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