KEGG ORTHOLOGY: K05198

ORTHOLOGY: K05198

Entry

K05198                      KO

Symbol

GRIA2

Name

glutamate receptor 2

Pathway

map04024

cAMP signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04082

Neuroactive ligand signaling

map04713

Circadian entrainment

map04720

Long-term potentiation

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04728

Dopaminergic synapse

map04730

Long-term depression

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05017

Spinocerebellar ataxia

map05022

Pathways of neurodegeneration - multiple diseases

map05030

Cocaine addiction

map05031

Amphetamine addiction

map05033

Nicotine addiction

Disease

H02705

Neurodevelopmental disorder with glutamatergic synapse dysfunction

H02887

Neurodevelopmental disorder with language impairment and behavioral abnormalities

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K05198  GRIA2; glutamate receptor 2
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K05198  GRIA2; glutamate receptor 2
   04082 Neuroactive ligand signaling
    K05198  GRIA2; glutamate receptor 2
09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K05198  GRIA2; glutamate receptor 2
   04728 Dopaminergic synapse
    K05198  GRIA2; glutamate receptor 2
   04720 Long-term potentiation
    K05198  GRIA2; glutamate receptor 2
   04730 Long-term depression
    K05198  GRIA2; glutamate receptor 2
   04723 Retrograde endocannabinoid signaling
    K05198  GRIA2; glutamate receptor 2
  09159 Environmental adaptation
   04713 Circadian entrainment
    K05198  GRIA2; glutamate receptor 2
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K05198  GRIA2; glutamate receptor 2
   05016 Huntington disease
    K05198  GRIA2; glutamate receptor 2
   05017 Spinocerebellar ataxia
    K05198  GRIA2; glutamate receptor 2
   05022 Pathways of neurodegeneration - multiple diseases
    K05198  GRIA2; glutamate receptor 2
  09165 Substance dependence
   05030 Cocaine addiction
    K05198  GRIA2; glutamate receptor 2
   05031 Amphetamine addiction
    K05198  GRIA2; glutamate receptor 2
   05033 Nicotine addiction
    K05198  GRIA2; glutamate receptor 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K05198  GRIA2; glutamate receptor 2
Ion channels [BR:ko04040]
Ligand-gated channels
  Glutamate (ionotropic)
   K05198  GRIA2; glutamate receptor 2

Other DBs

GO:	0004971 0005234 0015277

TC:	1.A.10.1.13

Genes

HSA:	2891(GRIA2)

PTR:	461570(GRIA2)

PPS:	100979970(GRIA2)

GGO:	101146262(GRIA2)

PON:	100438964(GRIA2)

PPYG:

129035351(GRIA2)

NLE:	100587219(GRIA2)

HMH:	116463465 116463489

SSYN:

129481173(GRIA2)

MCC:	574344(GRIA2)

MCF:	102133810(GRIA2)

MTHB:

126954308

MNI:	105488623(GRIA2)

CSAB:

103236440(GRIA2)

CATY:

105597886(GRIA2)

PANU:

101026424(GRIA2)

TGE:	112624741(GRIA2)

MLEU:

105532333(GRIA2)

RRO:	104658112(GRIA2)

RBB:	108529017(GRIA2)

PTEH:

111553388(GRIA2)

CANG:

105524448(GRIA2)

CJC:	100392029(GRIA2)

SBQ:	101037380(GRIA2)

CIMI:

108302423(GRIA2)

ANAN:

105714537(GRIA2)

CSYR:

103274889(GRIA2)

MMUR:

105881765(GRIA2)

LCAT:

123638517(GRIA2)

PCOQ:

105817329(GRIA2)

OGA:	100965104(GRIA2)

MMU:	14800(Gria2)

MCAL:

110292004(Gria2)

MPAH:

110320188(Gria2)

RNO:	29627(Gria2)

MCOC:

116093023(Gria2)

ANU:	117707728(Gria2)

ASYL:

127683236(Gria2)

MUN:	110565366(Gria2)

CGE:	100764344(Gria2)

MAUA:

101828199(Gria2)

PROB:

127232868(Gria2)

PLEU:

114700488(Gria2)

PMAV:

102920836(Gria2)

MORG:

121452885(Gria2)

MFOT:

126511550

AAMP:

119826282(Gria2)

NGI:	103751007(Gria2)

HGL:	101708417(Gria2)

CPOC:

100379153(Gria2)

CCAN:

109677927(Gria2)

DORD:

105995906(Gria2)

DSP:	122097803(Gria2)

DMER:

138820881(Gria2)

PLOP:

125364392(Gria2)

NCAR:

124994514

MMMA:

107141203(Gria2)

ITI:	101975335(Gria2)

OCU:

100357153

OPI:	101529969(GRIA2)

OCZ:	121150422(GRIA2)

TUP:	102480104(GRIA2)

GVR:	103606746(GRIA2)

CFA:	482667(GRIA2)

CLUD:

112654419(GRIA2)

VVP:	112926917(GRIA2)

VLG:	121480895(GRIA2)

NPO:	129516741(GRIA2)

AML:	100480171(GRIA2)

UMR:	103658055(GRIA2)

UAH:	113255793(GRIA2)

UAR:	123793191(GRIA2)

ELK:

111153762

LLV:

125093104

MPUF:

101694457(GRIA2)

MNP:	132000814(GRIA2)

MLK:	131831720(GRIA2)

NVS:	122889500(GRIA2)

ORO:	101377360(GRIA2)

EJU:	114210193(GRIA2)

ZCA:	113924448(GRIA2)

MLX:	118022427(GRIA2)

NSU:	110588667(GRIA2)

LWW:	102736769(GRIA2)

FCA:	101088234(GRIA2)

PYU:	121028050(GRIA2)

PCOO:

112858348(GRIA2)

PBG:	122475059(GRIA2)

PVIV:

125163820(GRIA2)

LRUF:

124520524

LGF:	123590958(GRIA2)

AJU:

106986586

PTG:	102971505(GRIA2)

PPAD:

109262480(GRIA2)

PUC:

125923148

PLEZ:

122216951(GRIA2)

HHV:	120248504(GRIA2)

BTA:	614283(GRIA2)

BOM:	102281980(GRIA2)

BIU:	109571560(GRIA2)

BBUB:

102391738(GRIA2)

BBIS:

104985749(GRIA2)

CHX:	102168378(GRIA2)

OAS:	443272(GRIA2)

BTAX:

128062005(GRIA2)

CSUM:

138093863(GRIA2)

ODA:	120871508(GRIA2)

CCAD:

122453582(GRIA2)

MREE:

136145608(GRIA2)

OVR:	110127815(GRIA2)

MBEZ:

129542260(GRIA2)

SSC:	100622950(GRIA2)

CFR:	102509459(GRIA2)

CBAI:

105069377(GRIA2)

CDK:	105101175(GRIA2)

VPC:	102542018(GRIA2)

BACU:

103017187(GRIA2)

BMUS:

118895927(GRIA2)

LVE:	103076655(GRIA2)

OOR:	101277565(GRIA2)

LALB:

132519158(GRIA2)

GMF:	115858145(GRIA2)

DDP:	132425695(GRIA2)

DLE:	111179014(GRIA2)

PCAD:

102979311(GRIA2)

PSIU:

116754193(GRIA2)

PPHC:

136123292(GRIA2)

NASI:

112400406(GRIA2)

ECB:	100069331(GRIA2)

EPZ:	103547313(GRIA2)

EAI:	106833065(GRIA2)

MYB:	102247019(GRIA2)

MYD:	102770040(GRIA2)

MMYO:

118659034(GRIA2)

MLF:	102441353(GRIA2)

MDT:	132235411(GRIA2)

MYUM:

139010663(GRIA2)

PKL:	118711189(GRIA2)

EFUS:

103288753(GRIA2)

MNA:	107527540(GRIA2)

DRO:	112312372(GRIA2)

SHON:

118995350(GRIA2)

AJM:	119034644(GRIA2)

PDIC:

114502356(GRIA2)

PHAS:

123813766(GRIA2)

MMF:	118615494(GRIA2)

PPAM:

129072576(GRIA2)

HAI:	109372942(GRIA2)

RFQ:	117037765(GRIA2)

PALE:

102891151(GRIA2)

PGIG:

120613443(GRIA2)

PVP:	105292202(GRIA2)

RAY:	107507556(GRIA2)

MJV:	108409350(GRIA2)

TOD:	119234204(GRIA2)

SARA:

101537905(GRIA2)

SFUM:

130028418(GRIA2)

SETR:

126003411(GRIA2)

LAV:	104846717(GRIA2)

TMU:

101358855

ETF:	101648272(GRIA2)

DNM:	101435246(GRIA2)

MDO:	100023645(GRIA2)

GAS:	123252946(GRIA2)

SHR:	100927884(GRIA2)

AFZ:

127541782

PCW:	110213704(GRIA2)

TVP:	118853298(GRIA2)

PBRV:

138175200(GRIA2)

MLAO:

141517748(GRIA2)

OAA:	100079654(GRIA2)

TACU:

119935540(GRIA2)

GGA:	414894(GRIA2)

PCOC:

116243139(GRIA2)

MGP:	100548135(GRIA2)

CJO:	107313045(GRIA2)

TPAI:

128084361(GRIA2)

LMUT:

125691599(GRIA2)

NMEL:

110398628(GRIA2)

APLA:

101800939(GRIA2)

ACYG:

106032365(GRIA2)

CATA:

118248707(GRIA2)

AFUL:

116488486(GRIA2)

TGU:	751775(GRIA2)

LSR:	110475435(GRIA2)

SCAN:

103825953(GRIA2)

PMOA:

120497904(GRIA2)

OTC:	121348462(GRIA2)

PRUF:

121360200(GRIA2)

ATRC:

139592299(GRIA2)

GFR:	102035371(GRIA2)

FAB:	101807440(GRIA2)

OMA:	130252587(GRIA2)

PHI:	102107469(GRIA2)

PMAJ:

107203040(GRIA2)

CCAE:

111928425(GRIA2)

CCW:	104697187(GRIA2)

CBRC:

103622898(GRIA2)

ACOE:

138109705(GRIA2)

ETL:	114057054(GRIA2)

ZAB:	102074463(GRIA2)

ZLE:	135446652(GRIA2)

ACHL:

103809208

SVG:	106857539(GRIA2)

MMEA:

130579156(GRIA2)

HRT:	120753174(GRIA2)

SATI:

136360427(GRIA2)

CFAI:

136291220(GRIA2)

CCIC:

134044487(GRIA2)

FPG:	101921318(GRIA2)

FCH:	102047853(GRIA2)

CCRI:

104161415(GRIA2)

NNT:

104400345

SHAB:

115610259(GRIA2)

ACUN:

113479701(GRIA2)

SURA:

141942727(GRIA2)

TALA:

104367681(GRIA2)

ACHC:

115350853(GRIA2)

HALD:

104319377(GRIA2)

HLE:	104843261(GRIA2)

AGEN:

126052629

HHAR:

128137221(GRIA2)

GCL:

127016251

CSTI:

104550563

LDI:	104350434(GRIA2)

MNB:	103775318(GRIA2)

DPUB:

104298471(GRIA2)

PPUS:

135178135(GRIA2)

AVIT:

104272909(GRIA2)

BRHI:

104496097(GRIA2)

EGZ:	104124150(GRIA2)

NNI:	104021358(GRIA2)

PCRI:

104032811(GRIA2)

PCAO:

104047534

PADL:

103918089(GRIA2)

AFOR:

103902296(GRIA2)

FGA:	104074537(GRIA2)

CBOR:

142081983(GRIA2)

GSTE:

104258484(GRIA2)

CBOY:

140651743(GRIA2)

MAME:

142409179(GRIA2)

CLV:	102087287(GRIA2)

CNIC:

135988422(GRIA2)

MUI:	104537949(GRIA2)

PGUU:

104459713(GRIA2)

PLET:

104615528(GRIA2)

EHS:

104504182

CMAC:

104477105(GRIA2)

CUCA:

104063515(GRIA2)

TEO:	104377406(GRIA2)

BREG:

104630550(GRIA2)

GAME:

129205843(GRIA2)

OHA:	104331665(GRIA2)

ACAR:

104526339

CPEA:

104387271(GRIA2)

CVF:	104294191(GRIA2)

RTD:	128909964(GRIA2)

CRID:

134516343(GRIA2)

LMIC:

141744248(GRIA2)

AAM:	106491878(GRIA2)

AROW:

112976722(GRIA2)

NPD:	112949237(GRIA2)

TGT:

104578939

DNE:	112995312(GRIA2)

SCAM:

104145561(GRIA2)

ASN:	102379192(GRIA2)

AMJ:	102568556(GRIA2)

CPOO:

109309703(GRIA2)

GGN:	109300848(GRIA2)

PSS:	102453143(GRIA2)

CIZ:	142012596(GRIA2)

CMY:	102939547(GRIA2)

CCAY:

125635613(GRIA2)

DCC:	119855272(GRIA2)

CPIC:

101943858(GRIA2)

TST:	117877562(GRIA2)

CABI:

116823754(GRIA2)

MRV:	120406068(GRIA2)

ACS:	100567723(gria2)

ASAO:

132776773(GRIA2)

PVT:	110072800(GRIA2)

SUND:

121930799(GRIA2)

PBI:	103060229(GRIA2)

PMUR:

107297577

CTIG:

120313116(GRIA2)

TSR:	106549387(GRIA2)

PGUT:

117674712(GRIA2)

PCAE:

139320197(GRIA2)

APRI:

131203451(GRIA2)

PTEX:

113435863(GRIA2)

NSS:	113417439(GRIA2)

VKO:	123023736(GRIA2)

PMUA:

114604010(GRIA2)

PRAF:

128420931(GRIA2)

ZVI:	118083843(GRIA2)

HCG:	128327883(GRIA2)

GJA:	107126247(GRIA2)

STOW:

125439960(GRIA2)

EMC:	129336469(GRIA2)

XLA:	100294514(gria2.S) 108699208

XTR:	100216082(gria2)

NPR:	108797651(GRIA2)

RTEM:

120920268(GRIA2)

ACAT:

141112695(GRIA2)

PADS:

140326939(GRIA2)

BBUF:

120990072(GRIA2)

BGAR:

122942455(GRIA2)

DTC:	141091113(GRIA2)

PWL:	138303800(GRIA2)

MUO:	115459492 115462679(GRIA2)

GSH:	117366788(GRIA2)

DRE:	170450(gria2a) 170451(gria2b)

SRX:	107723812 107740107 107745055 107750427

SANH:

107655932 107662960 107669079 107702389

SGH:	107548351 107554451 107591557 107602554(gria2)

CCAR:

109046097 109046307 109089992 109101739

CAUA:

113044236 113057996 113058018 113089000 113092928 113107123

CGIB:

127948972 127959434 127971831 128027640

PTET:

122343561(gria2a) 122357773(gria2b)

LROH:

127164679(gria2a) 127175987(gria2b)

GRF:	141288698(gria2b) 141337014(gria2a)

OMC:	131540873(gria2a) 131553216(gria2b)

PPRM:

120474337(gria2b) 120493861(gria2a)

RKG:	130089542(gria2a) 130095151(gria2b)

MAMB:

125259145(gria2b) 125272619(gria2a)

CIDE:

127494523 127516231

CERY:

137014504(gria2b) 137033155(gria2a)

MASI:

127412902 127418054 127444032 127444492

TROS:

130552489(gria2a) 130563587(gria2b)

TDW:	130436189(gria2a) 130437682(gria2b)

MANU:

129422306(gria2b) 129444697(gria2a)

PDAB:

135735952(gria2a) 135757820(gria2b)

IPU:	108260487(gria2a) 108268435(gria2b)

IFU:	128604247(gria2a) 128612078(gria2b)

PHYP:

113547169 113547342

SMEO:

124381130(gria2a) 124385845(gria2b)

TFD:	113635448(gria2a) 113648178(gria2b)

TVC:	132841945(gria2a) 132855598(gria2b)

CGAR:

128508164(gria2a) 128531597(gria2b)

NGRA:

132882757(gria2a) 132889984(gria2b)

TRN:	134319375(gria2b) 134326966(gria2a)

AMEX:

103028119(gria2a) 103039282(gria2b)

CMAO:

118807287(gria2b) 118817058(gria2a)

EEE:	113582437 113589646

CHAR:

105903928(gria2a) 105906167(gria2b)

SPIL:

134059526(gria2a) 134095610

ASAD:

121682001(gria2b) 121716501(gria2a)

TRU:	101066366(gria2)

TFS:	130531203(gria2b)

LCO:	104928602(gria2) 104936473

NCC:	104949508(gria2)

TBEN:

117474923 117491512(gria2b)

CGOB:

115014256(gria2) 115014292

PGEO:

117453692(gria2b) 117455313

GACU:

117551595 117553601(gria2b)

EMAC:

134859674(gria2b) 134864810

ELY:	117255943 117260637(gria2b)

EFO:	125885624 125894022(gria2b)

PLEP:

121941996 121947738(gria2b)

SLUC:

116052901(gria2b) 116056516

ECRA:

117951332(gria2b) 117957810

ESP:	116696511(gria2) 116701446

PFLV:

114562329(gria2) 114564267

GAT:	120817203(gria2b) 120824716

PPUG:

119210202(gria2b) 119218641

AFB:	129090436(gria2b) 129096532

CLUM:

117730462 117737285(gria2b)

PSWI:

130189966 130209622(gria2b)

CANA:

137793020 137795763(gria2b)

CVE:	137866399 137875727(gria2b)

MSAM:

119889188(gria2b)

SCHU:

122873249 122880484(gria2b)

CUD:	121507736 121516189(gria2b)

SPUL:

138598226(gria2b) 138604883

LMIX:

132981626(gria2b) 132986774

HTC:	141793056(gria2b) 141810026

ALAT:

119007739(gria2b) 119024484

ASTR:

137602673(gria2b)

MZE:	101466731(gria2) 101477932

ONL:	100534557(gria2b) 100534587(glur2a)

OAU:	116329646 116335252(gria2b)

OLA:	101168274(gria2)

OML:	112139724(gria2b)

CSAI:

133446803(gria2b)

XMA:	102233910(gria2) 102236866

XCO:	114139115(gria2) 114144400

XHE:	116714210(gria2) 116720229

PRET:

103470494 103471841(gria2)

PFOR:

103137332(gria2) 103146616

PLAI:

106947123(gria2) 106954491

PMEI:

106914863(gria2) 106924931

GAF:	122829158 122836892(gria2b)

PPRL:

129360298 129360303

CVG:	107091722(gria2) 107099602

CTUL:

119772622(gria2b) 119772939

GMU:	124860237(gria2b) 124868039

NFU:	107379888(gria2) 107382442

KMR:	108236653(gria2b) 108246920

ALIM:

106511393 106513254(gria2)

NWH:	119408348(gria2b) 119422994

AOCE:

111570676 111574991(gria2b)

EJA:	138211407(gria2b) 138213873

BFRE:

138622731(gria2b) 138636632

MCEP:

125003900 125007790(gria2b)

CSEM:

103384293 103390669(gria2)

POV:	109627207 109640028(gria2)

SSEN:

122770522 122778185(gria2b)

SSOE:

131467047 131472120(gria2b)

HHIP:

117769093(gria2b) 117772311

HSP:	118112618(gria2b) 118118864

PPLT:

128436696 128445636(gria2b)

SMAU:

118312962 118319478(gria2b)

LCF:	108885189(gria2b) 108900100

SDU:	111230445 111232357(gria2)

SLAL:

111648228(gria2) 111673578

XGL:	120785274(gria2b) 120800583

HCQ:	109526263(gria2)

SSCV:

125979636(gria2b)

SBIA:

133508479(gria2b)

PEE:	133407312(gria2b)

PTAO:

133484686(gria2b)

BPEC:

110153740(gria2) 110157786

ENY:	140348659(gria2b) 140377177

MALB:

109964278(gria2) 109975013

BSPL:

114851284 114864042(gria2b)

SJO:	128363336(gria2b) 128369380

SSCO:

133985477(gria2b) 133987691

TTY:	137179653 137189823(gria2b)

GMH:	115540764 115552495(gria2)

SASA:

106604527 106611560

STRU:

115170654 115183660 115183661 115205107

OTW:	112221056 112235712 112256336

OMY:	100499599 110488933 110515175 110516909

OGO:	123993513 124011119 124026773

ONE:	115129552 115130814

OKI:	109864847(gria2) 109879248 109884997 109905282

OKE:	118363594 118379641 118383072

OMM:	135526501 135545981

OCLA:

139366360 139374568 139390538 139419156

SALP:

111965837(gria2) 111967582

SNH:	120047417(gria2b) 120061982

SFON:

129827971 129858255(gria2b)

CCLU:

121534602 121541443(gria2b) 121561257

ELS:	105007598 105027675(gria2)

OEP:	134032217(gria2b) 134033383(gria2a)

SFM:	108924471 108930836(gria2)

PKI:	111833296 111837356(gria2)

AANG:

118228019 118232291

AROT:

135254832 135259808

CCOG:

133130175 133134657

LOC:	102688092(gria2)

PSPA:

121295240 121322913

ARUT:

117408841 117421519

PSEX:

120527166(gria2b)

CMK:	103182265(gria2b)

RTP:	109934081(gria2b)

CPLA:

122539304

CPUN:

140485762(gria2b)

HOC:	132833408(gria2b)

SCAU:

119963321(gria2b)

STOZ:

140408507

LERI:

129703378(gria2b)

HAKA:

140726519(gria2b)

PMRN:

116937492

BFO:	118411205 118419242 118419644 118419645 118422148

BBEL:

109468918 109470728 109470730 109480873 109486067

LPIC:

129262092

LVG:	121405878 121414973 121415634 121415636

AJJ:

APLC:

ARUN:

AAMU:

AJC:

SKO:

PFLL:

RZE:

AME:

ALAB:

BHUN:

CGIG:

MPHA:

CCOA:

TCZ:

TSEP:

COBS:

TLN:

CFO:

FEX:

PMEC:

MJU:

DMK:

PJA:

HAME:

ESN:

HAZT:

RMP:

CVS:

UDV:

SDM:

LPOL:

PMEO:

PVUL:

126821666 126824355 126829511 126829737

LSAX:

138969535

BARL:

143283854 143298714

BGT:	106056784 106064032 106067466 106075810

GAE:	121367454 121374378 121374379 121374913 121374915

HRF:	124112635 124112650 124112652 124133088 124146958 124146965 124146968

HRJ:	124261588 124280989 124283073 124283075 124283148

HASI:

137273039 137282287 137295834

HCRA:

139445618 139449381 139462536

CRG:	105326127 105331118 105331119 105336269

CANU:

128157394 128193102

CVN:	111122956 111124655 111125526 111126024 111126516

OED:	125679998 125680027 125680452

PMAX:

117329284 117329526 117329527

AIRR:

138326684 138326685 138326687 138327050

YBA:	132561645 132561646

MCAF:

127715509 127715510

MMER:

123556284 123557909 123558703

RPHI:

132724029 132732647 132758102

DPOL:

127854552 127854556 127876513 127876523 127879002

MAEA:

128226268 128226351 128228022 128228045 128228937

OSN:	115210959 115213120

LJP:	135472754 135474102

LLON:

135484174 135497267 135501420 135501706 135501848

ATEN:

MCAZ:

PDAM:

RES:

Reference

PMID:8003671

Authors

Sun W, Ferrer-Montiel AV, Montal M

Title

Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain.

Journal

Neuroreport 5:441-4 (1994)
DOI:10.1097/00001756-199401120-00018

Sequence

[hsa:2891]

LinkDB

DBGET integrated database retrieval system