KEGG   DRUG: IpragliflozinHelp
Entry
D10196                      Drug                                   

Name
Ipragliflozin (INN)
Formula
C21H21FO5S
Exact mass
404.1094
Mol weight
404.4518
Structure
Mol fileKCF fileDB search
Class
Antidiabetic agent
 DG01794  SGLT2 inhibitor
 DG02044  Hypoglycemics
  DG01794  SGLT2 inhibitor
Remark
Chemical structure group: DG01248
Product (DG01248): D10200<JP>
Product (mixture): D11064<JP>
Efficacy
Antidiabetic, SGLT-2 inhibitor
Comment
Phlorizin derivative
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: UGT2B7 [HSA:7364]; UGT2B4 [HSA:7363], UGT1A8 [HSA:54576], UGT1A9 [HSA:54600]
Interaction
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D10196  Ipragliflozin (INN)
BRITE hierarchy
Other DBs
CAS: 761423-87-4
PubChem: 163312229
ChEMBL: CHEMBL2018096
LinkDB All DBs
KCF data Show

ATOM        28
            1   O2x O    13.0900  -18.2700
            2   C1y C    13.0900  -19.6700
            3   C1y C    11.9000  -20.3700
            4   C1y C    10.6400  -19.6700
            5   C1y C    10.6400  -18.2700
            6   C1y C    11.9000  -17.5700
            7   C1b C    11.9000  -16.1700
            8   O1a O     9.4500  -20.3700
            9   C8y C    14.2800  -20.3700
            10  O1a O    13.0900  -15.4700
            11  O1a O     9.4500  -17.5700
            12  O1a O    11.9000  -21.7700
            13  C8x C    15.4700  -19.6700
            14  C8y C    16.7300  -20.3700
            15  C8y C    16.7300  -21.7700
            16  C8x C    15.5400  -22.4700
            17  C8x C    14.2800  -21.7700
            18  X   F    17.9200  -22.4700
            19  C1b C    17.9200  -19.6700
            20  C8y C    19.1100  -20.3700
            21  S2x S    20.4400  -20.0200
            22  C8y C    21.2100  -21.1400
            23  C8y C    20.3700  -22.1900
            24  C8x C    19.1100  -21.7000
            25  C8x C    22.6100  -21.3500
            26  C8x C    23.1000  -22.6800
            27  C8x C    22.2600  -23.7300
            28  C8x C    20.8600  -23.5200
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 1 #Up
            8     4   8 1 #Up
            9     2   9 1 #Up
            10    7  10 1
            11    5  11 1 #Down
            12    3  12 1 #Down
            13    9  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18    9  17 1
            19   15  18 1
            20   14  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   20  24 2
            27   22  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   23  28 2

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