KEGG   DRUG: Ipragliflozin L-prolineHelp
Entry
D10200                      Drug                                   

Name
Ipragliflozin L-proline (JAN);
Suglat (TN)
Formula
C21H21FO5S. C5H9NO2
Exact mass
519.1727
Mol weight
519.5823
Structure
Mol fileKCF fileDB search
Class
Antidiabetic agent
 DG01794  SGLT2 inhibitor
 DG02044  Hypoglycemics
  DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 3969
ATC code: A10BK05
Chemical structure group: DG01248
Product (DG01248): D10200<JP>
Product (mixture): D11064<JP>
Efficacy
Antidiabetic, SGLT-2 inhibitor
Comment
Phlorizin derivative
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: UGT2B7 [HSA:7364]; UGT2B4 [HSA:7363], UGT1A8 [HSA:54576], UGT1A9 [HSA:54600]
Interaction
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
     A10BK05 Ipragliflozin
      D10200  Ipragliflozin L-proline (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D10200  Ipragliflozin L-proline (JAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D10200  Ipragliflozin L-proline (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10200
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10200
BRITE hierarchy
Other DBs
PubChem: 163312233
LinkDB All DBs
KCF data Show

ATOM        36
            1   O2x O     7.7700  -15.5400
            2   C1y C     7.7700  -16.9400
            3   C1y C     6.5800  -17.6400
            4   C1y C     5.3200  -16.9400
            5   C1y C     5.3200  -15.5400
            6   C1y C     6.5800  -14.8400
            7   C1b C     6.5800  -13.3700
            8   O1a O     4.1300  -17.6400
            9   C8y C     8.9600  -17.6400
            10  O1a O     7.7700  -12.6700
            11  O1a O     4.1300  -14.8400
            12  O1a O     6.5800  -19.0400
            13  C8x C    10.1500  -16.9400
            14  C8y C    11.4800  -17.6400
            15  C8y C    11.4800  -19.0400
            16  C8x C    10.2200  -19.7400
            17  C8x C     8.9600  -19.0400
            18  X   F    12.6700  -19.7400
            19  C1b C    12.6700  -16.9400
            20  C8y C    13.8600  -17.6400
            21  S2x S    15.1900  -17.2900
            22  C8y C    15.9600  -18.4100
            23  C8y C    15.1200  -19.4600
            24  C8x C    13.8600  -18.9700
            25  C8x C    17.3600  -18.6200
            26  C8x C    17.8500  -19.9500
            27  C8x C    17.0100  -21.0000
            28  C8x C    15.6100  -20.7900
            29  C1x C    20.6500  -17.7100
            30  C1x C    21.0700  -19.0400
            31  C1x C    22.4700  -19.0400
            32  C1y C    22.8900  -17.7100
            33  N1x N    21.7700  -16.8700
            34  C6a C    24.0800  -17.0100
            35  O6a O    25.2700  -17.7100
            36  O6a O    24.0800  -15.6100
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 1 #Up
            8     4   8 1 #Up
            9     2   9 1 #Up
            10    7  10 1
            11    5  11 1 #Down
            12    3  12 1 #Down
            13    9  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18    9  17 1
            19   15  18 1
            20   14  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   20  24 2
            27   22  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   23  28 2
            32   29  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   29  33 1
            37   34  35 1
            38   32  34 1 #Down
            39   34  36 2

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