KEGG   DRUG: Ipragliflozin L-proline
Entry
D10200                      Drug                                   

Name
Ipragliflozin L-proline (JAN);
Suglat (TN)
Formula
C21H21FO5S. C5H9NO2
Exact mass
519.1727
Mol weight
519.5823
Structure
Class
Antidiabetic agent
 DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03190  UGT2B7 substrate
Remark
Therapeutic category: 3969
ATC code: A10BK05
Chemical structure group: DG01248
Product (DG01248): D10196<US> D10200<JP>
Product (mixture): D11064<JP>
Efficacy
Antidiabetic, SGLT-2 inhibitor
Comment
Phlorizin derivative
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: UGT2B7 [HSA:7364]
Interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
     A10BK05 Ipragliflozin
      D10200  Ipragliflozin L-proline (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D10200  Ipragliflozin L-proline (JAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D10200  Ipragliflozin L-proline (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10200
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10200
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10200
Other DBs
PubChem: 163312233
ChEMBL: CHEMBL4297658
LinkDB
KCF data

ATOM        36
            1   O2x O     7.7700  -15.5400
            2   C1y C     7.7700  -16.9400
            3   C1y C     6.5800  -17.6400
            4   C1y C     5.3200  -16.9400
            5   C1y C     5.3200  -15.5400
            6   C1y C     6.5800  -14.8400
            7   C1b C     6.5800  -13.3700
            8   O1a O     4.1300  -17.6400
            9   C8y C     8.9600  -17.6400
            10  O1a O     7.7700  -12.6700
            11  O1a O     4.1300  -14.8400
            12  O1a O     6.5800  -19.0400
            13  C8x C    10.1500  -16.9400
            14  C8y C    11.4800  -17.6400
            15  C8y C    11.4800  -19.0400
            16  C8x C    10.2200  -19.7400
            17  C8x C     8.9600  -19.0400
            18  X   F    12.6700  -19.7400
            19  C1b C    12.6700  -16.9400
            20  C8y C    13.8600  -17.6400
            21  S2x S    15.1900  -17.2900
            22  C8y C    15.9600  -18.4100
            23  C8y C    15.1200  -19.4600
            24  C8x C    13.8600  -18.9700
            25  C8x C    17.3600  -18.6200
            26  C8x C    17.8500  -19.9500
            27  C8x C    17.0100  -21.0000
            28  C8x C    15.6100  -20.7900
            29  C1x C    20.6500  -17.7100
            30  C1x C    21.0700  -19.0400
            31  C1x C    22.4700  -19.0400
            32  C1y C    22.8900  -17.7100
            33  N1x N    21.7700  -16.8700
            34  C6a C    24.0800  -17.0100
            35  O6a O    25.2700  -17.7100
            36  O6a O    24.0800  -15.6100
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 1 #Up
            8     4   8 1 #Up
            9     2   9 1 #Up
            10    7  10 1
            11    5  11 1 #Down
            12    3  12 1 #Down
            13    9  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18    9  17 1
            19   15  18 1
            20   14  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   20  24 2
            27   22  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   23  28 2
            32   29  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   29  33 1
            37   34  35 1
            38   32  34 1 #Down
            39   34  36 2

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