KEGG   DRUG: Saxagliptin hydrochloride
Entry
D10262                      Drug                                   
Name
Saxagliptin hydrochloride;
Onglyza (TN)
Product
ONGLYZA (AstraZeneca Pharmaceuticals LP), ONGLYZA (Cardinal Health 107)
  Generic
SAXAGLIPTIN (Amneal Pharmaceuticals LLC), SAXAGLIPTIN (Mylan Pharmaceuticals)
Formula
C18H25N3O2. HCl
Exact mass
351.1714
Mol weight
351.87
Structure
Simcomp
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG01601  DPP-4 inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
ATC code: A10BH03
Chemical structure group: DG00119
Product (DG00119): D09753<JP/US> D10262<US>
Product (mixture): D10263<US> D10826<US>
Efficacy
Antidiabetic, Dipeptidyl peptidase-4 (DPP-4) inhibitor
Comment
Treatment of type II diabetes mellitus and metabolic syndrome
Target
DPP4 (CD26) [HSA:1803] [KO:K01278]
  Pathway
hsa04974  Protein digestion and absorption
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BH Dipeptidyl peptidase 4 (DPP-4) inhibitors
     A10BH03 Saxagliptin
      D10262  Saxagliptin hydrochloride <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Dipeptidyl Peptidase-4 (DPP-4) Inhibitor
    Saxagliptin
     D10262  Saxagliptin hydrochloride
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01601  DPP-4 inhibitor
    DG00119  Saxagliptin
     D10262  Saxagliptin hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00119  Saxagliptin
     D10262  Saxagliptin hydrochloride
  DG02925  CYP3A5 substrate
   DG00119  Saxagliptin
    D10262  Saxagliptin hydrochloride
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01601  DPP-4 inhibitor
   D10262  Saxagliptin hydrochloride
  DG02044  Hypoglycemic agent
   D10262  Saxagliptin hydrochloride
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Prolyl oligopeptidase family
    DPP4 (CD26)
     D10262  Saxagliptin hydrochloride <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10262
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10262
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10262
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10262
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01601  DPP-4 inhibitor
    DG00119  Saxagliptin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00119  Saxagliptin
  DG02925  CYP3A5 substrate
   DG00119  Saxagliptin
Other DBs
CAS: 709031-78-7
PubChem: 163312293
LinkDB
KCF data

ATOM        24
            1   C1z C    19.3200  -17.4300
            2   C1x C    18.6200  -18.8300
            3   C1y C    18.6200  -20.0900
            4   C1y C    18.1300  -19.3900
            5   C1z C    20.4400  -19.3900
            6   C1x C    17.0800  -20.5100
            7   C1x C    19.7400  -21.0700
            8   C1x C    18.1300  -18.0600
            9   C1x C    19.3200  -20.0200
            10  C1x C    20.4400  -18.0600
            11  C1c C    19.3200  -16.0300
            12  C5a C    20.5100  -15.4000
            13  N1a N    18.1300  -15.4000
            14  N1y N    21.7000  -16.0300
            15  O5a O    20.5100  -14.0000
            16  C1y C    22.1200  -17.3600
            17  C1y C    23.5200  -17.3600
            18  C1x C    23.9400  -15.9600
            19  C1y C    22.7500  -15.2600
            20  C3b C    22.7500  -13.8600
            21  N3a N    22.7500  -12.4600
            22  O1a O    21.7700  -19.3900
            23  C1x C    22.8200  -18.5500
            24  X   Cl   27.2300  -19.8100
BOND        27
            1     1   2 1
            2     2   3 1
            3     8   4 1
            4     4   9 1
            5     9   5 1
            6     5  10 1
            7    10   1 1
            8     1   8 1
            9     3   6 1
            10    3   7 1
            11    4   6 1
            12    5   7 1
            13    1  11 1
            14   11  12 1
            15   11  13 1 #Down
            16   12  14 1
            17   12  15 2
            18   14  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   14  19 1
            23   19  20 1 #Down
            24   20  21 3
            25    5  22 1
            26   17  23 1
            27   23  16 1

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