KEGG   DRUG: DusigitumabHelp
Entry
D10352                      Drug                                   

Name
Dusigitumab (USAN)
Formula
C6372H9824N1700O2016S54
Exact mass
144142.3386
Mol weight
144231.8734
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT SYDINWVRQA TGQGLEWMGW MNPNSGNTGY
AQKFQGRVTM TRNTSISTAY MELSSLRSED TAVYYCARDP YYYYYGMDVW GQGTTVTVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER KCCVECPPCP APPVAGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTFR
VVSVLTVVHQ DWLNGKEYKC KVSNKGLPAP IEKTISKTKG QPREPQVYTL PPSREEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPMLDSD GSFFLYSKLT VDKSRWQQGN
VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
QSVLTQPPSV SAAPGQKVTI SCSGSSSNIE NNHVSWYQQL PGTAPKLLIY DNNKRPSGIP
DRFSGSKSGT SATLGITGLQ TGDEADYYCE TWDTSLSAGR VFGGGTKLTV LGQPKAAPSV
TLFPPSSEEL QANKATLVCL ISDFYPGAVT VAWKADSSPV KAGVETTTPS KQSNNKYAAS
SYLSLTPEQW KSHRSYSCQV THEGSTVEKT VAPTECS
(dimer; dislfide bridges: H22-H96, H134-L216, H147-H203, H222-H'222, H223-H'223, H226-H'226, H229-H'229, H260-H320, H366-H424, H'22-H'96, H'134-L'216, H'147-H'203, H'260-H'320, H'366-H'424, L22-L89, L139-L198, L'22-L'89, L'139-L'198)
  Type
Peptide
Efficacy
Antineoplastic, Anti-insulin-like growth factor 2 antibody
Comment
Monoclonal antibody
Target
IGF2 [HSA:3481] [KO:K13769]
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Non-receptor tyrosine kinases
   InsR family
    IGF2
     D10352  Dusigitumab (USAN)
BRITE hierarchy
Other DBs
CAS: 1204390-13-5
PubChem: 172232445
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