KEGG   Homo sapiens (human): 3481
Entry
3481              CDS       T01001                                 
Symbol
IGF2, C11orf43, GRDF, IGF-II, PP9974, SRS3
Name
(RefSeq) insulin like growth factor 2
  KO
K13769  insulin-like growth factor 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04081  Hormone signaling
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05225  Hepatocellular carcinoma
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06324  GHRH-GH-IGF signaling
nt06526  MAPK signaling
nt06530  PI3K signaling
  Element
N00233  IGF-IGF1R-RAS-ERK signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00235  IGF2-overexpression to RAS-ERK signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00237  IGF1R-overexpression to RAS-ERK signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N01592  GF-RTK-RAS-ERK signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
Disease
H00033  Adrenal carcinoma
H00048  Hepatocellular carcinoma
H00711  Russell-Silver syndrome
H00713  Beckwith-Wiedemann syndrome
Drug target
Dusigitumab: D10352
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    3481 (IGF2)
   04151 PI3K-Akt signaling pathway
    3481 (IGF2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    3481 (IGF2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3481 (IGF2)
   05205 Proteoglycans in cancer
    3481 (IGF2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    3481 (IGF2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    3481 (IGF2)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    3481 (IGF2)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Growth factors (RTK binding)
   3481 (IGF2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   3481 (IGF2)
SSDB
Motif
Pfam: IGF2_C Insulin
Other DBs
NCBI-GeneID: 3481
NCBI-ProteinID: NP_000603
OMIM: 147470
HGNC: 5466
Ensembl: ENSG00000167244
CPD: C16132
UniProt: P01344
Structure
LinkDB
Position
11:complement(2129117..2149566)
AA seq 180 aa
MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVS
RRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWK
QSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK
NT seq 543 nt   +upstreamnt  +downstreamnt
atgggaatcccaatggggaagtcgatgctggtgcttctcaccttcttggccttcgcctcg
tgctgcattgctgcttaccgccccagtgagaccctgtgcggcggggagctggtggacacc
ctccagttcgtctgtggggaccgcggcttctacttcagcaggcccgcaagccgtgtgagc
cgtcgcagccgtggcatcgttgaggagtgctgtttccgcagctgtgacctggccctcctg
gagacgtactgtgctacccccgccaagtccgagagggacgtgtcgacccctccgaccgtg
cttccggacaacttccccagataccccgtgggcaagttcttccaatatgacacctggaag
cagtccacccagcgcctgcgcaggggcctgcctgccctcctgcgtgcccgccggggtcac
gtgctcgccaaggagctcgaggcgttcagggaggccaaacgtcaccgtcccctgattgct
ctacccacccaagaccccgcccacgggggcgcccccccagagatggccagcaatcggaag
tga

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