KEGG ORTHOLOGY: K13769

ORTHOLOGY: K13769

Entry

K13769                      KO

Symbol

IGF2

Name

insulin-like growth factor 2

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04151

PI3K-Akt signaling pathway

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05225

Hepatocellular carcinoma

Disease

H00033

Adrenal carcinoma

H00048

Hepatocellular carcinoma

H00711

Russell-Silver syndrome

H00713

Beckwith-Wiedemann syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K13769  IGF2; insulin-like growth factor 2
   04014 Ras signaling pathway
    K13769  IGF2; insulin-like growth factor 2
   04151 PI3K-Akt signaling pathway
    K13769  IGF2; insulin-like growth factor 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K13769  IGF2; insulin-like growth factor 2
   05205 Proteoglycans in cancer
    K13769  IGF2; insulin-like growth factor 2
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K13769  IGF2; insulin-like growth factor 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K13769  IGF2; insulin-like growth factor 2
   00536 Glycosaminoglycan binding proteins
    K13769  IGF2; insulin-like growth factor 2
Cytokines and growth factors [BR:ko04052]
Growth factors
  Growth factors (RTK binding)
   K13769  IGF2; insulin-like growth factor 2
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K13769  IGF2; insulin-like growth factor 2

Other DBs

GO:

0005159

Genes

HSA:	3481(IGF2)

PTR:	742381(IGF2)

PPS:	100968468(IGF2)

GGO:	101133471(IGF2)

PON:	100453365(IGF2)

NLE:	100585821(IGF2)

MCC:	710802(IGF2)

MCF:	102126663(IGF2)

CSAB:

103239180(IGF2)

CATY:

105577264(IGF2)

PANU:

100137527(IGF2)

TGE:	112605601(IGF2)

RRO:	104677104(IGF2)

RBB:	108539209(IGF2)

TFN:	117081142(IGF2)

PTEH:

111520622(IGF2)

CJC:	100393815(IGF2)

SBQ:	101036519(IGF2)

CSYR:

103252407(IGF2)

MMUR:

105859821(IGF2)

OGA:	100958631(IGF2)

MMU:	16002(Igf2)

MCAL:

110298427(Igf2)

MPAH:

110316402(Igf2)

RNO:	24483(Igf2)

MCOC:

116103249(Igf2)

MUN:	110546690(Igf2)

CGE:	100762359(Igf2)

PLEU:

114694075

NGI:	103738988(Igf2)

HGL:	101720309(Igf2)

CPOC:

100135552(Igf2)

CCAN:

109689792(Igf2)

DORD:

105989243(Igf2)

DSP:	122102070(Igf2)

OCU:	100328792(IGF2)

OPI:	101534278(IGF2)

TUP:	102481608(IGF2)

CFA:	483664(IGF2)

VVP:	112924139(IGF2)

VLG:	121471414(IGF2)

AML:

100483184

UMR:	103671055(IGF2)

UAH:	113243959(IGF2)

UAR:	123775501(IGF2)

ELK:

111150034

MPUF:

101683091(IGF2)

ORO:	101384061(IGF2)

EJU:	114220405(IGF2)

ZCA:	113914579(IGF2)

MLX:	118016186(IGF2)

FCA:	101093644(IGF2)

PYU:	121023964(IGF2)

PBG:	122484126(IGF2)

PPAD:

109259410(IGF2)

AJU:	113595529(IGF2)

HHV:	120225512(IGF2) 120226895

BTA:	281240(IGF2)

BOM:	102274689(IGF2)

BIU:	109554335(IGF2)

BBUB:

102395378(IGF2)

CHX:	100861277(IGF2)

OAS:	443325(IGF2)

ODA:	120874172(IGF2)

CCAD:

122430978(IGF2)

SSC:	396916(IGF2)

CFR:	102515540(IGF2)

CBAI:

105070386(IGF2)

CDK:	105106402(IGF2)

BACU:

102997276(IGF2)

LVE:	103084737(IGF2)

OOR:	101278742(IGF2)

DLE:	111183604(IGF2)

PCAD:

102973168(IGF2)

PSIU:

116758167(IGF2)

ECB:	100034182(IGF2)

EPZ:	103567613(IGF2)

EAI:

106824098

MYB:	102247355(IGF2)

MMYO:

118659613(IGF2)

MNA:	107539909(IGF2)

PKL:	118713981(IGF2)

HAI:	109395935(IGF2)

DRO:	112317267(IGF2)

SHON:

118988333(IGF2)

AJM:	119057543(IGF2)

PDIC:

114500628(IGF2)

PHAS:

123807352(IGF2)

MMF:	118628029(IGF2)

RFQ:	117030019(IGF2)

PALE:

102880410(IGF2)

PGIG:

120584609(IGF2)

PVP:	105299512(IGF2)

RAY:	107513179(IGF2)

MJV:	108402612(IGF2)

TOD:	119249859(IGF2)

SARA:

101545641(IGF2)

LAV:	100664990(IGF2)

DNM:

101427189

SHR:	100928068(IGF2)

PCW:	110197133(IGF2)

OAA:	791102(IGF2)

GGA:	395097(IGF2)

PCOC:

116242920(IGF2)

MGP:	100303676(IGF2)

CJO:	107314538(IGF2)

NMEL:

110400777(IGF2)

APLA:

101799111(IGF2)

ACYG:

106042580(IGF2)

AFUL:

116490287(IGF2)

TGU:	100218445(IGF2)

LSR:	110468650(IGF2)

SCAN:

103826753(IGF2)

PMOA:

120511416(IGF2)

OTC:	121341566(IGF2)

PRUF:

121361011(IGF2)

GFR:	102032627(IGF2)

FAB:	101812363(IGF2)

PHI:	102111387(IGF2)

PMAJ:

107206324(IGF2)

CCAE:

111930776(IGF2)

CCW:	104687627(IGF2)

ETL:	114059841(IGF2)

ZAB:	102072593(IGF2)

FPG:	101915916(IGF2)

FCH:	102057742(IGF2)

CLV:	102094702(IGF2)

EGZ:	104124918(IGF2)

NNI:	104010403(IGF2)

ACUN:

113481190(IGF2)

TALA:

116959655(IGF2)

PADL:

103920755(IGF2)

ACHC:

115352007(IGF2)

AAM:	106496994(IGF2)

AROW:

112972443(IGF2)

NPD:	112945240(IGF2)

DNE:	112978931(IGF2)

ASN:	102378893(IGF2)

AMJ:	102565996(IGF2)

CPOO:

109321161(IGF2)

GGN:	109299170(IGF2)

PSS:	102445459(IGF2)

CMY:	102935902(IGF2)

CPIC:

101937814(IGF2)

TST:	117877300(IGF2)

CABI:

116819354(IGF2)

MRV:	120404869(IGF2)

ACS:	100565807(igf2)

PVT:	110076544(IGF2)

SUND:

121928414(IGF2)

PBI:	103061017(IGF2)

PMUR:

107299015(IGF2)

TSR:	106544616(IGF2)

PGUT:

117665227(IGF2)

VKO:	123021242(IGF2)

PMUA:

114599121(IGF2)

ZVI:	118087959(IGF2)

GJA:	107123375(IGF2)

XLA:	108697782 398240(igf2.S) 398245(igf3.L) 432206(igf2.L)

XTR:	100134992(igf2) 100145502(igf3)

NPR:	108791995(IGF2) 108800079

RTEM:

120916507 120917285(IGF2)

BBUF:

120981201(IGF2) 121002472

BGAR:

122920014(IGF2) 122926676

DRE:	30710(igf2a) 324215(igf2b)

SRX:	107707559 107707874 107730252 107740557

SANH:

107675272 107688559 107694097 107696640 107699238

SGH:	107553858 107562518 107572879 107596433

CCAR:

109070618 109085243 109098538 109098540

CAUA:

113043588 113051344 113067106 113077627 113106245 113107060 113107146

IPU:	100304637(igf2b) 100528676(igf2a)

PHYP:

113530057 113540971

SMEO:

124379688(igf2a) 124392809(igf2b)

AMEX:

103024122 103027656 103045269

EEE:	113579707 113587279 113589508

TRU:	100462940(igf2)

TNG:	GSTEN00019790G001

LCO:	109140778(igf2)

NCC:	104966228(igf2)

CGOB:

115009855(igf2)

ELY:	117262363(igf2b)

PLEP:

121949712(igf2b)

SLUC:

116038464(igf2b)

ECRA:

117948913(igf2b)

PFLV:

114559835(igf2)

GAT:	120809586 120812711

PPUG:

119195941(igf2b)

MSAM:

119893407(igf2b)

CUD:	121514978(igf2b)

MZE:	101468736(igf2)

ONL:	100534429(igf2)

OAU:	116328931(igf2b)

OLA:	101172047(igf2)

OML:	112152449(igf2b)

XMA:	102222127(igf2)

XCO:	114158858(igf2)

XHE:	116734169(igf2)

PRET:

103466159(igf2)

PFOR:

103144431

PLAI:

106959917

PMEI:

106905258

GAF:	122835000(igf2b)

CVG:

107089487

CTUL:

119796811(igf2b)

NFU:	107389021(igf2)

KMR:	108237538(igf2b)

ALIM:

106515666(igf2)

NWH:	119416210(igf2b)

AOCE:

111582532

CSEM:

103380367(igf2)

POV:	109638971(igf2)

SSEN:

122775717(igf2b)

HHIP:

117763124(igf2b)

LCF:	108875327(igf2)

SDU:	111228384(igf2)

SLAL:

111661852(igf2)

XGL:	120793416(igf2b)

HCQ:	109530494(igf2)

BPEC:

110165965(igf2)

MALB:

109967897(igf2)

SASA:

100136550(IGF-II) 106572168

OTW:	112218392(igf2b)

OMY:	100136742(igf2b)

OGO:	124040836(igf2b)

ONE:

115134630

SALP:

111961991

SNH:	120066020(igf2b)

ELS:

105005983

SFM:	108934699 108942432

PKI:	111841410 111859481

AANG:

118215239 118227841(igf2b)

LOC:	102684037(igf2)

PSPA:

121294909 121329499

ARUT:

117431928 117435150

LCM:	102347414 102348010(IGF2)

CMK:	103186041 103190280

RTP:	109927421 109934227

BBEL:

109477594

AAG:

5565037

AALB:

109412111 109430943

CQU:	CpipJ_CPIJ003329

CPII:

CNS:

LHU:

TPRE:

AGIF:

MSEX:

DPL:	KGM_207480

BANY:

PXU:

PRAP:

DNX:

AGS:

RMD:

DCI:	103520706 103521704

HHAL:

106690341

DMK:	116916215 116917991

RSAN:

RMP:

VDE:

VJA:

DFR:

PTEP:

SDM:	118185032 118185033 118196016

PCAN:

HRF:

MYI:

PMAX:

MMER:

Reference

PMID:6382021

Authors

Bell GI, Merryweather JP, Sanchez-Pescador R, Stempien MM, Priestley L, Scott J, Rall LB

Title

Sequence of a cDNA clone encoding human preproinsulin-like growth factor II.

Journal

Nature 310:775-7 (1984)
DOI:10.1038/310775a0

Sequence

[hsa:3481]

Reference

PMID:12087403

Authors

Constancia M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C, Reik W

Title

Placental-specific IGF-II is a major modulator of placental and fetal growth.

Journal

Nature 417:945-8 (2002)
DOI:10.1038/nature00819

Reference

PMID:9722981

Authors

O'Dell SD, Day IN

Title

Insulin-like growth factor II (IGF-II).

Journal

Int J Biochem Cell Biol 30:767-71 (1998)
DOI:10.1016/S1357-2725(98)00048-X

LinkDB

DBGET integrated database retrieval system