KEGG   DRUG: Vonoprazan fumarateHelp
Entry
D10466                      Drug                                   

Name
Vonoprazan fumarate (JAN);
Takecab (TN)
Formula
C17H16FN3O2S. C4H4O4
Exact mass
461.1057
Mol weight
461.4634
Structure
Mol fileKCF fileDB search
Class
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2329
Product: D10466<JP>
Product (mixture): D10775<JP> D10774<JP>
Efficacy
Anti-ulcerative, Proton pump inhibitor
Comment
Potassium competitive acid blocker (P-CAB)
Target
ATP4 [HSA:495 496] [KO:K01542 K01543]
  Pathway
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2B6 [HSA:1555], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D10466  Vonoprazan fumarate (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D10466  Vonoprazan fumarate (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10466
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10466
BRITE hierarchy
Other DBs
CAS: 881681-01-2
PubChem: 172232559
ChEMBL: CHEMBL2064032
LinkDB All DBs
KCF data Show

ATOM        32
            1   C8x C     8.7500  -18.5500
            2   C8x C     8.7500  -19.9500
            3   C8x C     9.9400  -20.6500
            4   C8y C    11.2000  -19.9500
            5   C8x C    11.2000  -18.5500
            6   N5x N     9.9400  -17.8500
            7   S4a S    12.3900  -20.6500
            8   N4y N    13.5800  -19.9500
            9   O3c O    11.4100  -21.6300
            10  O3c O    13.3700  -21.6300
            11  C8y C    14.9100  -20.3700
            12  C8x C    15.6800  -19.2500
            13  C8y C    14.9100  -18.2000
            14  C8x C    13.5800  -18.6200
            15  C8x C    14.9100  -22.7500
            16  C8x C    15.5400  -24.0100
            17  C8x C    16.9400  -24.0100
            18  C8x C    17.7100  -22.8200
            19  C8y C    17.0100  -21.5600
            20  C8y C    15.6100  -21.5600
            21  X   F    17.7100  -20.3700
            22  C1b C    15.3452  -16.8694
            23  N1b N    16.7452  -16.8694
            24  C1a C    17.4410  -15.6640
            25  C6a C    21.6300  -19.2500
            26  C2b C    22.8424  -19.9500
            27  O6a O    20.4176  -19.9500
            28  O6a O    21.6300  -17.8500
            29  C2b C    24.0379  -19.2596
            30  C6a C    25.2253  -19.9451
            31  O6a O    26.4165  -19.2571
            32  O6a O    25.2255  -21.3498
BOND        33
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     7   9 2
            10    7  10 2
            11    8  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    8  14 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   15  20 1
            22   20  11 1
            23   19  21 1
            24   13  22 1
            25   22  23 1
            26   23  24 1
            27   25  26 1
            28   25  27 1
            29   25  28 2
            30   26  29 2
            31   29  30 1
            32   30  31 1
            33   30  32 2

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