KEGG   DRUG: Vonoprazan fumarateHelp
Entry
D10466                      Drug                                   

Name
Vonoprazan fumarate (JAN);
Takecab (TN)
Formula
C17H16FN3O2S. C4H4O4
Exact mass
461.1057
Mol weight
461.4634
Structure
Mol fileKCF fileDB search
Class
Enzyme substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 2329
Product: D10466<JP>
Product (mixture): D10775<JP> D10774<JP>
Efficacy
Anti-ulcerative, Proton pump inhibitor
Comment
Potassium competitive acid blocker (P-CAB)
Target
ATP4 [HSA:495 496] [KO:K01542 K01543]
  Pathway
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2B6 [HSA:1555], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D10466  Vonoprazan fumarate (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D10466  Vonoprazan fumarate (JAN) <JP>
Drug classes of therapeutic agents [br08360.html]
 Gastrointestinal agents
  D10466
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10466
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10466
BRITE hierarchy
Other DBs
CAS: 881681-01-2
PubChem: 172232559
ChEMBL: CHEMBL2064032
LinkDB All DBs
KCF data Show

ATOM        32
            1   C8x C     8.7500  -18.5500
            2   C8x C     8.7500  -19.9500
            3   C8x C     9.9400  -20.6500
            4   C8y C    11.2000  -19.9500
            5   C8x C    11.2000  -18.5500
            6   N5x N     9.9400  -17.8500
            7   S4a S    12.3900  -20.6500
            8   N4y N    13.5800  -19.9500
            9   O3c O    11.4100  -21.6300
            10  O3c O    13.3700  -21.6300
            11  C8y C    14.9100  -20.3700
            12  C8x C    15.6800  -19.2500
            13  C8y C    14.9100  -18.2000
            14  C8x C    13.5800  -18.6200
            15  C8x C    14.9100  -22.7500
            16  C8x C    15.5400  -24.0100
            17  C8x C    16.9400  -24.0100
            18  C8x C    17.7100  -22.8200
            19  C8y C    17.0100  -21.5600
            20  C8y C    15.6100  -21.5600
            21  X   F    17.7100  -20.3700
            22  C1b C    15.3452  -16.8694
            23  N1b N    16.7452  -16.8694
            24  C1a C    17.4410  -15.6640
            25  C6a C    21.6300  -19.2500
            26  C2b C    22.8424  -19.9500
            27  O6a O    20.4176  -19.9500
            28  O6a O    21.6300  -17.8500
            29  C2b C    24.0379  -19.2596
            30  C6a C    25.2253  -19.9451
            31  O6a O    26.4165  -19.2571
            32  O6a O    25.2255  -21.3498
BOND        33
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     7   9 2
            10    7  10 2
            11    8  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    8  14 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   15  20 1
            22   20  11 1
            23   19  21 1
            24   13  22 1
            25   22  23 1
            26   23  24 1
            27   25  26 1
            28   25  27 1
            29   25  28 2
            30   26  29 2
            31   29  30 1
            32   30  31 1
            33   30  32 2

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