| Entry |
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| Name |
Vonoprazan fumarate (JAN/USAN);
Takecab (TN);
Voquezna (TN) |
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| Product |
|
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| Formula |
C17H16FN3O2S. C4H4O4
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| Exact mass |
461.1057
|
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| Mol weight |
461.4634
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| Structure |
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| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2329 |
| Product (DG03104): | D10466<JP/US> |
| Product (mixture): | D10774<JP> D10775<JP> D11804<JP> |
|
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| Efficacy |
Anti-ulcerative, Proton pump inhibitor |
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| Disease |
Erosive esophagitis [DS: H01602] Helicobacter pylori infection [DS: H00320] |
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| Comment |
Potassium competitive acid blocker (P-CAB)
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2B6 [HSA: 1555], CYP2C19 [HSA: 1557], CYP2D6 [HSA: 1565]
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC08 Vonoprazan
D10466 Vonoprazan fumarate (JAN/USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
232 Peptic ulcer agents
2329 Others
D10466 Vonoprazan fumarate (JAN/USAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG03104 Vonoprazan
D10466 Vonoprazan fumarate
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG03104 Vonoprazan
D10466 Vonoprazan fumarate
DG01639 CYP2C19 substrate
DG03104 Vonoprazan
D10466 Vonoprazan fumarate
DG01644 CYP2D6 substrate
DG03104 Vonoprazan
D10466 Vonoprazan fumarate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03104 Vonoprazan
D10466 Vonoprazan fumarate
Drug classes [BR:br08332]
Gastrointestinal agent
DG01646 Proton pump inhibitor (PPI)
D10466 Vonoprazan fumarate
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D10466 Vonoprazan fumarate (JAN/USAN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D10466
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D10466
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10466
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG03104 Vonoprazan
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG03104 Vonoprazan
DG01639 CYP2C19 substrate
DG03104 Vonoprazan
DG01644 CYP2D6 substrate
DG03104 Vonoprazan
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03104 Vonoprazan
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 C8x C 8.7500 -18.5500
2 C8x C 8.7500 -19.9500
3 C8x C 9.9400 -20.6500
4 C8y C 11.2000 -19.9500
5 C8x C 11.2000 -18.5500
6 N5x N 9.9400 -17.8500
7 S4a S 12.3900 -20.6500
8 N4y N 13.5800 -19.9500
9 O3c O 11.4100 -21.6300
10 O3c O 13.3700 -21.6300
11 C8y C 14.9100 -20.3700
12 C8x C 15.6800 -19.2500
13 C8y C 14.9100 -18.2000
14 C8x C 13.5800 -18.6200
15 C8x C 14.9100 -22.7500
16 C8x C 15.5400 -24.0100
17 C8x C 16.9400 -24.0100
18 C8x C 17.7100 -22.8200
19 C8y C 17.0100 -21.5600
20 C8y C 15.6100 -21.5600
21 X F 17.7100 -20.3700
22 C1b C 15.3452 -16.8694
23 N1b N 16.7452 -16.8694
24 C1a C 17.4410 -15.6640
25 C6a C 21.6300 -19.2500
26 C2b C 22.8424 -19.9500
27 O6a O 20.4176 -19.9500
28 O6a O 21.6300 -17.8500
29 C2b C 24.0379 -19.2596
30 C6a C 25.2253 -19.9451
31 O6a O 26.4165 -19.2571
32 O6a O 25.2255 -21.3498
BOND 33
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 7 9 2
10 7 10 2
11 8 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 8 14 1
16 15 16 2
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 2
21 15 20 1
22 20 11 1
23 19 21 1
24 13 22 1
25 22 23 1
26 23 24 1
27 25 26 1
28 25 27 1
29 25 28 2
30 26 29 2
31 29 30 1
32 30 31 1
33 30 32 2
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