KEGG   DRUG: Peginterferon beta-1a
Entry
D10483                      Drug                                   
Name
Peginterferon beta-1a (USAN/INN);
Plegridy (TN)
Product
PLEGRIDY (Biogen)
Formula
C913H1417N246O256PS7 [C2H4O]n
Sequence
*MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF
QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED
FTRGKLMS*SL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN
(Disulfide bridge: 31-141)
  Type
Peptide
Class
Immunological agent
 DG01752  Interferone
Remark
ATC code: L03AB13
Product: D10483<US>
Efficacy
Immunomodulator, Biological response modifier
  Disease
Multiple sclerosis [DS:H01490]
Comment
Treatment of multiple sclerosis
Target
IFNAR1 [HSA:3454] [KO:K05130]
IFNAR2 [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB13 Peginterferon beta-1a
      D10483  Peginterferon beta-1a (USAN/INN) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Multiple Sclerosis Agents
   Peginterferon Beta-1a
    D10483  Peginterferon beta-1a (USAN/INN)
Drug groups [BR:br08330]
 Immunological agent
  DG01752  Interferone
   D10483  Peginterferon beta-1a
Drug classes [BR:br08332]
 Immunological agent
  DG01752  Interferone
   D10483  Peginterferon beta-1a
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interferon receptors
    IFNAR1
     D10483  Peginterferon beta-1a (USAN/INN) <US>
    IFNAR2
     D10483  Peginterferon beta-1a (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10483
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10483
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10483
Other DBs
CAS: 1211327-92-2
PubChem: 172232576
LinkDB

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