KEGG   DRUG: Fosnetupitant and palonosetron hydrochloride
Entry
D10572            Mixture   Drug                                   

Name
Fosnetupitant and palonosetron hydrochloride;
Netupitant and palonosetron hydrochloride;
Akynzeo (TN)
Product
Component
(Netupitant [DR:D05152] | Fosnetupitant [DR:D11065]), (Palonocetron hydrochloride [DR:D05343] | Palonosetron [DR:D07175])
Remark
ATC code: A04AA55
Product: D10572<US>
Efficacy
Anti-emetic
Comment
Netupitant is metabolized by CYP3A4 with some contribution from CYP2C9 and CYP2D6.
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2C9 [HSA:1559], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA55 Palonosetron, combinations
      D10572  Fosnetupitant and palonosetron hydrochloride
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Fosnetupitant/ Palonosetron
    D10572  Fosnetupitant and palonosetron hydrochloride
   Netupitant/ Palonosetron
    D10572  Fosnetupitant and palonosetron hydrochloride
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10572
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10572
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10572
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10572
Other DBs
PubChem: 254741534
ChEBI: 85154
LinkDB

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