KEGG   DRUG: Palonosetron hydrochlorideHelp
Entry
D05343                      Drug                                   

Name
Palonosetron hydrochloride (JAN/USAN);
Aloxi (TN)
Product
  Generic
PALONOSETRON (BluePoint Laboratories), PALONOSETRON (Dr.Reddy's Laboratories Limited), PALONOSETRON (Fresenius Kabi USA), PALONOSETRON (Fresenius Kabi USA), PALONOSETRON (NorthStar Rx LLC), PALONOSETRON HYDROCHLORIDE (Accord Healthcare), PALONOSETRON (Apotex Corp.), PALONOSETRON HYDROCHLORIDE (AuroMedics Pharma LLC), PALONOSETRON HYDROCHLORIDE (Cipla USA), PALONOSETRON HYDROCHLORIDE (Hospira), PALONOSETRON HYDROCHLORIDE (Mylan Institutional LLC), PALONOSETRON (Qilu Pharmaceutical), PALONOSETRON HYDROCHLORIDE (Sagent Pharmaceuticals), PALONOSETRON HYDROCHLORIDE (Sagent Pharmaceuticals), PALONOSETRON HYDROCHLORIDE (Sandoz), PALONOSETRON HYDROCHLORIDE (Sandoz), PALONOSETRON HYDROCHLORIDE (Teva Parenteral Medicines), PALONOSETRON HYDROCHLORIDE (Virtus Pharmaceuticals), PALONOSETRON HYDROCHLORIDE (Cipla USA)
Formula
C19H24N2O. HCl
Exact mass
332.1655
Mol weight
332.8676
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Gastrointestinal agent
 DG01762  Antiemetic
Other
 DG01489  5-HT3-receptor antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2391
ATC code: A04AA05
Chemical structure group: DG00064
Product (DG00064): D05343<JP/US>
Product (mixture): D10572<US>
Efficacy
Anti-emetic, Serotonin 5-HT3 receptor antagonist
Target
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA05 Palonosetron
      D05343  Palonosetron hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Palonosetron
    D05343  Palonosetron hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2391  Antiemetics
     D05343  Palonosetron hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3
     D05343  Palonosetron hydrochloride (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05343
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05343
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05343
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05343
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D05343
BRITE hierarchy
Other DBs
CAS: 135729-62-3
PubChem: 47207029
ChEBI: 85157
ChEMBL: CHEMBL1720
LigandBox: D05343
LinkDB All DBs
KCF data Show

ATOM        23
            1   N1y N    31.1604  -19.2289
            2   C5x C    32.5639  -19.2289
            3   C8y C    33.2656  -18.0359
            4   C8y C    32.5639  -16.8429
            5   C1y C    31.1604  -16.8427
            6   C1x C    30.4586  -17.9657
            7   C8y C    33.2656  -15.6499
            8   C1x C    32.5639  -14.3868
            9   C1x C    31.2306  -14.3868
            10  C1x C    30.5288  -15.5798
            11  C8x C    34.6691  -18.0359
            12  C8x C    35.3709  -16.8429
            13  C8x C    34.6691  -15.6499
            14  O5x O    33.2656  -20.4218
            15  C1y C    29.6867  -18.6675
            16  C1x C    29.0551  -19.6499
            17  N1y N    27.5814  -18.8078
            18  C1x C    27.5814  -17.5447
            19  C1x C    26.0376  -19.5797
            20  C1y C    28.3534  -17.7552
            21  C1x C    28.3534  -16.7727
            22  C1x C    26.7393  -18.4569
            23  X   Cl   37.2656  -18.5271
BOND        26
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    3  11 1
            13   11  12 2
            14   12  13 1
            15   13   7 2
            16    2  14 2
            17   16  17 1
            18   16  15 1
            19   17  18 1
            20   17  19 1
            21   15  20 1
            22   18  21 1
            23   19  22 1
            24   20  21 1
            25   20  22 1
            26   15   1 1 #Down

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