KEGG   DRUG: Etelcalcetide hydrochloride
Entry
D10677                      Drug                                   
Name
Etelcalcetide hydrochloride (JAN/USAN);
Velcalcetide hydrochloride (USAN);
Parsabiv (TN)
Product
PARSABIV (Amgen)
Formula
C38H73N21O10S2. xHCl
Structure
Simcomp
Remark
Therapeutic category: 3999
ATC code: H05BX04
Chemical structure group: DG01856
Product (DG01856): D10677<JP/US>
Efficacy
Antihyperparathyroidism, Calcium-sensing receptor agonist
  Disease
Secondary hyperparathyroidism [DS:H01669]
Comment
Treatment of secondary hyperparathyroidism associated with chronic kidney disease
Target
CASR [HSA:846] [KO:K04612]
  Pathway
hsa04621  NOD-like receptor signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
  Network
nt06318  CaSR-PTH signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H05 CALCIUM HOMEOSTASIS
   H05B ANTI-PARATHYROID AGENTS
    H05BX Other anti-parathyroid agents
     H05BX04 Etelcalcetide
      D10677  Etelcalcetide hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Calcium-sensing Receptor Agonist
   Etelcalcetide
    D10677  Etelcalcetide hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D10677  Etelcalcetide hydrochloride (JAN/USAN); Velcalcetide hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Metabotropic glutamate receptor family
   Calcium-sensing
    CASR
     D10677  Etelcalcetide hydrochloride (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10677
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10677
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10677
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10677
Other DBs
CAS: 1334237-71-6
PubChem: 254741638
LinkDB
KCF data

ATOM        72
            1   C1c C     9.5200  -21.2800
            2   C6a C    10.7100  -21.9800
            3   O6a O    11.9700  -21.2800
            4   N1a N     8.2600  -21.9800
            5   O6a O    10.7100  -23.3800
            6   C5a C     9.5200  -15.6800
            7   C1c C    11.9700  -15.6800
            8   N1b N    10.7100  -14.9800
            9   C5a C    13.1600  -14.9800
            10  C5a C    15.6100  -13.5800
            11  C1c C    14.3500  -12.8800
            12  N1b N    13.1600  -13.5800
            13  C5a C    17.9900  -14.9800
            14  C1c C    17.9900  -13.5800
            15  N1b N    16.8000  -12.8800
            16  N1b N    19.1800  -15.6800
            17  C1c C    19.1800  -17.0800
            18  C5a C    20.4400  -17.7800
            19  N1b N    21.6300  -17.0800
            20  C1c C    22.8200  -17.7800
            21  C5a C    22.8200  -19.1800
            22  C1c C    24.0800  -21.2800
            23  N1b N    24.0800  -19.8800
            24  C5a C    25.2700  -21.9800
            25  N1b N    25.2700  -23.3800
            26  C1c C    26.4600  -24.0800
            27  C5a C    26.4600  -25.4800
            28  O5a O    27.7200  -26.1800
            29  C1a C     8.3300  -14.9800
            30  O5a O     9.5200  -17.0800
            31  O5a O    14.3500  -15.6800
            32  O5a O    15.6100  -14.9800
            33  O5a O    16.8000  -15.6800
            34  O5a O    20.4400  -19.1800
            35  O5a O    21.6300  -19.8800
            36  O5a O    26.4600  -21.2800
            37  S3a S    10.7100  -17.7800
            38  C1b C    11.9700  -17.0800
            39  S3a S    10.7100  -19.1800
            40  C1b C     9.5200  -19.8800
            41  C1b C    17.9900  -17.7800
            42  C1b C    17.9900  -19.1800
            43  C1b C    19.1800  -19.8800
            44  N1b N    19.1800  -21.2800
            45  C2c C    20.4400  -21.9800
            46  N1a N    21.6300  -21.2800
            47  N2a N    20.4400  -23.3800
            48  C1a C    22.8200  -21.9800
            49  C1a C    14.3500  -11.4800
            50  C1b C    19.1800  -12.8800
            51  C1b C    19.1800  -11.4800
            52  C1b C    20.4400  -10.7800
            53  N1b N    20.4400   -9.3800
            54  C2c C    21.6300   -8.6800
            55  N1a N    22.8200   -9.3800
            56  C1b C    24.0800  -17.0800
            57  C1b C    24.0800  -15.6800
            58  C1b C    25.2700  -14.9800
            59  N1b N    25.2700  -13.5800
            60  C2c C    24.0800  -12.8800
            61  N2a N    22.8200  -13.5800
            62  C1b C    27.7200  -23.3800
            63  N2a N    21.6300   -7.2800
            64  N1a N    24.0800  -11.4800
            65  C1b C    28.9100  -24.0800
            66  C1b C    30.1000  -23.3800
            67  N1b N    31.3600  -24.0800
            68  C2c C    32.5500  -23.3800
            69  N1a N    32.5500  -21.9800
            70  N2a N    33.7400  -24.0800
            71  N1a N    25.2700  -26.1800
            72  X   Cl   36.7500  -18.9700
BOND        70
            1     1   2 1
            2     2   3 1
            3     1   4 1
            4     2   5 2
            5     7   8 1
            6     6   8 1
            7     7   9 1
            8    10  11 1
            9    11  12 1
            10    9  12 1
            11   13  14 1
            12   14  15 1
            13   10  15 1
            14   13  16 1
            15   16  17 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   22  23 1
            21   21  23 1
            22   22  24 1
            23   24  25 1
            24   25  26 1
            25   26  27 1
            26   27  28 2
            27    6  29 1
            28    6  30 2
            29    9  31 2
            30   10  32 2
            31   13  33 2
            32   18  34 2
            33   21  35 2
            34   24  36 2
            35   37  38 1
            36   37  39 1
            37   39  40 1
            38    7  38 1 #Up
            39    1  40 1 #Up
            40   41  42 1
            41   42  43 1
            42   43  44 1
            43   44  45 1
            44   45  46 1
            45   45  47 2
            46   17  41 1 #Up
            47   22  48 1 #Up
            48   11  49 1 #Down
            49   50  51 1
            50   51  52 1
            51   52  53 1
            52   53  54 1
            53   54  55 1
            54   14  50 1 #Down
            55   56  57 1
            56   57  58 1
            57   58  59 1
            58   59  60 1
            59   60  61 2
            60   20  56 1 #Down
            61   26  62 1 #Down
            62   54  63 2
            63   60  64 1
            64   62  65 1
            65   65  66 1
            66   66  67 1
            67   67  68 1
            68   68  69 1
            69   68  70 2
            70   27  71 1
BRACKET     1    35.5600  -19.4600   35.5600  -18.2700
            1    37.3800  -18.2700   37.3800  -19.4600
            1  x
 ORIGINAL  1   72
 REPEAT    1

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