| Entry |
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| Symbol |
CASR, CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1, hCasR
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| Name |
(RefSeq) calcium sensing receptor
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| KO |
| K04612 | calcium-sensing receptor |
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| Organism |
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| Pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04928 | Parathyroid hormone synthesis, secretion and action |
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| Network |
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| Element |
| N00291 | CaSR-PTH signaling pathway |
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| Disease |
| H00245 | Calcium sensing receptor (CASR) related disease |
| H00246 | Primary hyperparathyroidism |
| H00808 | Idiopathic generalized epilepsies |
| H02026 | Familial hypocalciuric hypercalcemia |
| H02030 | Neonatal hyperparathyroidism |
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| Drug target |
| Ronacaleret hydrochloride: | D08991 |
| Tecalcet hydrochloride: | D06020 |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
846 (CASR)
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
846 (CASR)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:hsa04030]
846 (CASR)
G protein-coupled receptors [BR:hsa04030]
Metabotropic glutamate receptor family
Calcium-sensing
846 (CASR)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
3:122183668..122291629
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| AA seq |
1078 aa
MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA
SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS
SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP
RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGE
TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS |
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| NT seq |
3237 nt +upstreamnt +downstreamnt
atggcattttatagctgctgctgggtcctcttggcactcacctggcacacctctgcctac
gggccagaccagcgagcccaaaagaagggggacattatccttggggggctctttcctatt
cattttggagtagcagctaaagatcaagatctcaaatcaaggccggagtctgtggaatgt
atcaggtataatttccgtgggtttcgctggttacaggctatgatatttgccatagaggag
ataaacagcagcccagcccttcttcccaacttgacgctgggatacaggatatttgacact
tgcaacaccgtttctaaggccttggaagccaccctgagttttgttgctcaaaacaaaatt
gattctttgaaccttgatgagttctgcaactgctcagagcacattccctctacgattgct
gtggtgggagcaactggctcaggcgtctccacggcagtggcaaatctgctggggctcttc
tacattccccaggtcagttatgcctcctccagcagactcctcagcaacaagaatcaattc
aagtctttcctccgaaccatccccaatgatgagcaccaggccactgccatggcagacatc
atcgagtatttccgctggaactgggtgggcacaattgcagctgatgacgactatgggcgg
ccggggattgagaaattccgagaggaagctgaggaaagggatatctgcatcgacttcagt
gaactcatctcccagtactctgatgaggaagagatccagcatgtggtagaggtgattcaa
aattccacggccaaagtcatcgtggttttctccagtggcccagatcttgagcccctcatc
aaggagattgtccggcgcaatatcacgggcaagatctggctggccagcgaggcctgggcc
agctcctccctgatcgccatgcctcagtacttccacgtggttggcggcaccattggattc
gctctgaaggctgggcagatcccaggcttccgggaattcctgaagaaggtccatcccagg
aagtctgtccacaatggttttgccaaggagttttgggaagaaacatttaactgccacctc
caagaaggtgcaaaaggacctttacctgtggacacctttctgagaggtcacgaagaaagt
ggcgacaggtttagcaacagctcgacagccttccgacccctctgtacaggggatgagaac
atcagcagtgtcgagaccccttacatagattacacgcatttacggatatcctacaatgtg
tacttagcagtctactccattgcccacgccttgcaagatatatatacctgcttacctggg
agagggctcttcaccaatggctcctgtgcagacatcaagaaagttgaggcgtggcaggtc
ctgaagcacctacggcatctaaactttacaaacaatatgggggagcaggtgacctttgat
gagtgtggtgacctggtggggaactattccatcatcaactggcacctctccccagaggat
ggctccatcgtgtttaaggaagtcgggtattacaacgtctatgccaagaagggagaaaga
ctcttcatcaacgaggagaaaatcctgtggagtgggttctccagggaggtgcccttctcc
aactgcagccgagactgcctggcagggaccaggaaagggatcattgagggggagcccacc
tgctgctttgagtgtgtggagtgtcctgatggggagtatagtgatgagacagatgccagt
gcctgtaacaagtgcccagatgacttctggtccaatgagaaccacacctcctgcattgcc
aaggagatcgagtttctgtcgtggacggagccctttgggatcgcactcaccctctttgcc
gtgctgggcattttcctgacagcctttgtgctgggtgtgtttatcaagttccgcaacaca
cccattgtcaaggccaccaaccgagagctctcctacctcctcctcttctccctgctctgc
tgcttctccagctccctgttcttcatcggggagccccaggactggacgtgccgcctgcgc
cagccggcctttggcatcagcttcgtgctctgcatctcatgcatcctggtgaaaaccaac
cgtgtcctcctggtgtttgaggccaagatccccaccagcttccaccgcaagtggtggggg
ctcaacctgcagttcctgctggttttcctctgcaccttcatgcagattgtcatctgtgtg
atctggctctacaccgcgcccccgtcaagctaccgcaaccaggagctggaggatgagatc
atcttcatcacgtgccacgagggctccctcatggccctgggcttcctgatcggctacacc
tgcctgctggctgccatctgcttcttctttgccttcaagtcccggaagctgccggagaac
ttcaatgaagccaagttcatcaccttcagcatgctcatcttcttcatcgtctggatctcc
ttcattccagcctatgccagcacctatggcaagtttgtctctgccgtagaggtgattgcc
atcctggcagccagctttggcttgctggcgtgcatcttcttcaacaagatctacatcatt
ctcttcaagccatcccgcaacaccatcgaggaggtgcgttgcagcaccgcagctcacgct
ttcaaggtggctgcccgggccacgctgcgccgcagcaacgtctcccgcaagcggtccagc
agccttggaggctccacgggatccaccccctcctcctccatcagcagcaagagcaacagc
gaagacccattcccacagcccgagaggcagaagcagcagcagccgctggccctaacccag
caagagcagcagcagcagcccctgaccctcccacagcagcaacgatctcagcagcagccc
agatgcaagcagaaggtcatctttggcagcggcacggtcaccttctcactgagctttgat
gagcctcagaagaacgccatggcccacaggaattctacgcaccagaactccctggaggcc
cagaaaagcagcgatacgctgacccgacacgagccattactcccgctgcagtgcggggaa
acggacttagatctgaccgtccaggaaacaggtctgcaaggacctgtgggtggagaccag
cggccagaggtggaggaccctgaagagttgtccccagcacttgtagtgtccagttcacag
agctttgtcatcagtggtggaggcagcactgttacagaaaacgtagtgaattcataa |
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