Entry |
|
Name |
Fostemsavir tromethamine (USAN); Fostemsavir trometamol; Rukobia (TN) |
Abbr |
FTR |
Product |
|
Formula |
C25H26N7O8P. C4H11NO3
|
Exact mass |
704.2319
|
Mol weight |
704.62
|
Structure |
|
Simcomp |
|
Class |
Antiviral
DG03107 Anti-HIV agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Transporter substrate
DG01665 ABCB1 substrate
DG01913 ABCG2 substrate
Transporter inhibitor
DG02862 ABCG2 inhibitor
DG02865 SLCO1B1 inhibitor
DG02907 SLCO1B3 inhibitor
|
Remark |
Product (DG01860): | D10708<US> |
|
Efficacy |
Antiviral, gp120-directed attachment inhibitor |
Disease |
|
Comment |
Active form of prodrug: Temsavir [DR: D10734]
Treatment of HIV
|
Target |
|
Pathway |
ko03260 | Virion - Human immunodeficiency virus |
ko04061 | Viral protein interaction with cytokine and cytokine receptor |
ko05170 | Human immunodeficiency virus 1 infection |
|
Metabolism |
|
Interaction |
Transporter inhibition: ABCG2 [HSA: 9429], SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234]
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AX Other antivirals
J05AX29 Fostemsavir
D10708 Fostemsavir tromethamine (USAN) <US>
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Other
Fostemsavir
D10708 Fostemsavir tromethamine (USAN)
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
D10708 Fostemsavir tromethamine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01860 Temsavir
D10708 Fostemsavir tromethamine
Transporter substrate
DG01665 ABCB1 substrate
DG01860 Temsavir
D10708 Fostemsavir tromethamine
DG01913 ABCG2 substrate
DG01860 Temsavir
D10708 Fostemsavir tromethamine
Transporter inhibitor
DG02862 ABCG2 inhibitor
DG01860 Temsavir
D10708 Fostemsavir tromethamine
DG02865 SLCO1B1 inhibitor
DG01860 Temsavir
D10708 Fostemsavir tromethamine
DG02907 SLCO1B3 inhibitor
DG01860 Temsavir
D10708 Fostemsavir tromethamine
Drug classes [BR:br08332]
Antiviral
DG03107 Anti-HIV agent
D10708 Fostemsavir tromethamine
Antimicrobials [BR:br08307]
Antivirals
Entry, fusion or uncoating inhibitor
HIV gp41/gp120
D10708 Fostemsavir tromethamine (USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D10708
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10708
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D10708
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10708
Drug transporters
D10708
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01860 Temsavir
Transporter substrate
DG01665 ABCB1 substrate
DG01860 Temsavir
DG01913 ABCG2 substrate
DG01860 Temsavir
Transporter inhibitor
DG02862 ABCG2 inhibitor
DG01860 Temsavir
DG02865 SLCO1B1 inhibitor
DG01860 Temsavir
DG02907 SLCO1B3 inhibitor
DG01860 Temsavir
Prodrugs [br08324.html]
DG01860
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 49
1 N5x N 16.9400 -18.2700
2 C8x C 18.1300 -18.9700
3 C8y C 19.3900 -18.2700
4 C8y C 19.3900 -16.8700
5 C8y C 18.1300 -16.1700
6 C8y C 16.9400 -16.8700
7 C8y C 20.3700 -15.8900
8 C8x C 19.8100 -14.6300
9 N4y N 18.4100 -14.7700
10 N4y N 15.7500 -16.1700
11 C8x C 15.5400 -14.7700
12 N5x N 14.2100 -14.4900
13 C8y C 13.5100 -15.7500
14 N5x N 14.4900 -16.7300
15 C1a C 12.1100 -15.7500
16 C1b C 17.4300 -13.7900
17 O2b O 17.7800 -12.4600
18 P1b P 16.8000 -11.4800
19 O1c O 17.7800 -10.5000
20 O1c O 15.8200 -12.4600
21 O1c O 15.8200 -10.5000
22 O2a O 20.5800 -18.9700
23 C1a C 20.5800 -20.3700
24 C5a C 21.7700 -16.2400
25 O5a O 22.7500 -15.1900
26 C5a C 22.4700 -17.5000
27 O5a O 21.4900 -18.4800
28 N1y N 23.8000 -17.8500
29 C1x C 24.1500 -19.1800
30 C1x C 25.5500 -19.5300
31 N1y N 26.5300 -18.5500
32 C1x C 26.1800 -17.2200
33 C1x C 24.7800 -16.8000
34 C8x C 27.2300 -21.2100
35 C8y C 28.2800 -20.2300
36 C5a C 27.8600 -18.9000
37 C8x C 27.6500 -22.6100
38 C8x C 28.9800 -22.9600
39 C8x C 29.9600 -21.9100
40 C8x C 29.6100 -20.5800
41 O5a O 28.8400 -17.9200
42 O1a O 30.1700 -15.0500
43 C1b C 31.3600 -14.4200
44 C1d C 32.6200 -15.0500
45 C1b C 33.8100 -14.4200
46 O1a O 35.0700 -15.0500
47 N1a N 32.6200 -13.6500
48 C1b C 32.6200 -16.4500
49 O1a O 33.8800 -17.2200
BOND 52
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 2
9 8 9 1
10 5 9 1
11 6 10 1
12 10 11 1
13 11 12 2
14 12 13 1
15 13 14 2
16 10 14 1
17 13 15 1
18 9 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 18 20 1
23 18 21 2
24 3 22 1
25 22 23 1
26 7 24 1
27 24 25 2
28 24 26 1
29 26 27 2
30 26 28 1
31 28 29 1
32 29 30 1
33 30 31 1
34 31 32 1
35 32 33 1
36 28 33 1
37 34 35 2
38 35 36 1
39 31 36 1
40 34 37 1
41 37 38 2
42 38 39 1
43 39 40 2
44 35 40 1
45 36 41 2
46 42 43 1
47 43 44 1
48 44 45 1
49 45 46 1
50 44 47 1
51 44 48 1
52 48 49 1
|