KEGG   DRUG: Polatuzumab vedotin
Entry
D10761                      Drug                                   

Name
Polatuzumab vedotin (USAN);
Polatuzumab vedotin (genetical recombination) (JAN);
Polatuzumab vedotin-piiq;
Polivy (TN)
Product
Formula
C6670H10317N1745O2087S40
Exact mass
149533.3646
Mol weight
149625.3253
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 4291
ATC code: L01XC37
Product: D10761<JP/US>
Efficacy
Antineoplastic
  Disease
Diffuse large B-cell lymphoma [DS:H02434]
Comment
Antibody-drug conjugate
See Vedotin [DR:D09691]
Target
CD79B [HSA:974] [KO:K06507]
  Pathway
hsa04662  B cell receptor signaling pathway
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC37 Polatuzumab vedotin
      D10761  Polatuzumab vedotin (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Monoclonal Antibody/Antibody-Drug Conjugate
   Polatuzumab Vedotin
    D10761  Polatuzumab vedotin (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D10761  Polatuzumab vedotin (USAN); Polatuzumab vedotin (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD79B
     D10761  Polatuzumab vedotin (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10761
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10761
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10761
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10761
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10761
Other DBs
CAS: 1313206-42-6
PubChem: 295369351
LinkDB

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