KEGG   DRUG: Perampanel hydrateHelp
Entry
D10780                      Drug                                   

Name
Perampanel hydrate (JAN);
Fycompa (TN)
Product
Formula
(C23H15N3O)3. 4H2O
Exact mass
1119.4068
Mol weight
1120.2152
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01569  AMPA receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 1139
ATC code: N03AX22
Chemical structure group: DG01901
Product (DG01901): D10780<JP/US>
Efficacy
Antiepileptic, AMPA receptor antagonist
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX22 Perampanel
      D10780  Perampanel hydrate (JAN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Glutamate Reducing Agents
   Perampanel
    D10780  Perampanel hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D10780  Perampanel hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), non-NMDA
    GRIA
     D10780  Perampanel hydrate (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10780
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10780
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10780
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10780
BRITE hierarchy
Other DBs
CAS: 1571982-04-1
PubChem: 313046638
LinkDB All DBs
KCF data Show

ATOM        85
            1   C8x C    13.7779  -12.3092
            2   C8x C    13.7779  -13.7079
            3   C8y C    15.0367  -14.4073
            4   C8y C    16.2257  -13.7079
            5   C8x C    16.2257  -12.3092
            6   C8x C    15.0367  -11.6098
            7   C8y C    17.4846  -14.4772
            8   C8x C    17.4846  -15.8760
            9   C8y C    18.6735  -16.5754
            10  C8x C    19.8625  -15.8760
            11  N4y N    19.8625  -14.4772
            12  C8y C    18.6735  -13.7779
            13  C3b C    15.0367  -15.8760
            14  N3a N    15.0367  -17.2748
            15  C8y C    21.1214  -13.7779
            16  C8x C    22.3103  -14.4073
            17  C8x C    23.4993  -13.7079
            18  C8x C    23.4993  -12.3092
            19  C8x C    22.3103  -11.6098
            20  C8x C    21.1214  -12.3092
            21  C8y C    18.6735  -17.9742
            22  N5x N    17.4846  -18.6036
            23  C8x C    17.4846  -20.0024
            24  C8x C    18.6735  -20.7018
            25  C8x C    19.8625  -20.0723
            26  C8x C    19.8625  -18.6735
            27  O5x O    18.6735  -12.3092
            28  O0  O    28.7700  -17.1500
            29  C8x C    13.7779  -12.3092
            30  C8x C    13.7779  -13.7079
            31  C8y C    15.0367  -14.4073
            32  C8y C    16.2257  -13.7079
            33  C8x C    16.2257  -12.3092
            34  C8x C    15.0367  -11.6098
            35  C8y C    17.4846  -14.4772
            36  C8x C    17.4846  -15.8760
            37  C8y C    18.6735  -16.5754
            38  C8x C    19.8625  -15.8760
            39  N4y N    19.8625  -14.4772
            40  C8y C    18.6735  -13.7779
            41  O5x O    18.6735  -12.3092
            42  C8y C    21.1214  -13.7779
            43  C8x C    22.3103  -14.4073
            44  C8x C    23.4993  -13.7079
            45  C8x C    23.4993  -12.3092
            46  C8x C    22.3103  -11.6098
            47  C8x C    21.1214  -12.3092
            48  C8y C    18.6735  -17.9742
            49  N5x N    17.4846  -18.6036
            50  C8x C    17.4846  -20.0024
            51  C8x C    18.6735  -20.7018
            52  C8x C    19.8625  -20.0723
            53  C8x C    19.8625  -18.6735
            54  C3b C    15.0367  -15.8760
            55  N3a N    15.0367  -17.2748
            56  C8x C    13.7779  -12.3092
            57  C8x C    13.7779  -13.7079
            58  C8y C    15.0367  -14.4073
            59  C8y C    16.2257  -13.7079
            60  C8x C    16.2257  -12.3092
            61  C8x C    15.0367  -11.6098
            62  C8y C    17.4846  -14.4772
            63  C8x C    17.4846  -15.8760
            64  C8y C    18.6735  -16.5754
            65  C8x C    19.8625  -15.8760
            66  N4y N    19.8625  -14.4772
            67  C8y C    18.6735  -13.7779
            68  O5x O    18.6735  -12.3092
            69  C8y C    21.1214  -13.7779
            70  C8x C    22.3103  -14.4073
            71  C8x C    23.4993  -13.7079
            72  C8x C    23.4993  -12.3092
            73  C8x C    22.3103  -11.6098
            74  C8x C    21.1214  -12.3092
            75  C8y C    18.6735  -17.9742
            76  N5x N    17.4846  -18.6036
            77  C8x C    17.4846  -20.0024
            78  C8x C    18.6735  -20.7018
            79  C8x C    19.8625  -20.0723
            80  C8x C    19.8625  -18.6735
            81  C3b C    15.0367  -15.8760
            82  N3a N    15.0367  -17.2748
            83  O0  O    28.7700  -17.1500
            84  O0  O    28.7700  -17.1500
            85  O0  O    28.7700  -17.1500
BOND        90
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 1
            13    7  12 1
            14    3  13 1
            15   13  14 3
            16   11  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23    9  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   12  27 2
            31   29  30 2
            32   30  31 1
            33   31  32 2
            34   32  33 1
            35   33  34 2
            36   29  34 1
            37   32  35 1
            38   35  36 2
            39   36  37 1
            40   37  38 2
            41   38  39 1
            42   39  40 1
            43   35  40 1
            44   31  54 1
            45   54  55 3
            46   39  42 1
            47   42  43 2
            48   43  44 1
            49   44  45 2
            50   45  46 1
            51   46  47 2
            52   42  47 1
            53   37  48 1
            54   48  49 2
            55   49  50 1
            56   50  51 2
            57   51  52 1
            58   52  53 2
            59   48  53 1
            60   40  41 2
            61   56  57 2
            62   57  58 1
            63   58  59 2
            64   59  60 1
            65   60  61 2
            66   56  61 1
            67   59  62 1
            68   62  63 2
            69   63  64 1
            70   64  65 2
            71   65  66 1
            72   66  67 1
            73   62  67 1
            74   58  81 1
            75   81  82 3
            76   66  69 1
            77   69  70 2
            78   70  71 1
            79   71  72 2
            80   72  73 1
            81   73  74 2
            82   69  74 1
            83   64  75 1
            84   75  76 2
            85   76  77 1
            86   77  78 2
            87   78  79 1
            88   79  80 2
            89   75  80 1
            90   67  68 2
BRACKET     1    13.0900  -21.2100   13.0900  -10.9900
            1    23.9400  -10.9900   23.9400  -21.2100
            1  3
 ORIGINAL  1    1   2   3   4   5   6   7   8   9  10  11  12  27  15  16  17
            1   18  19  20  21  22  23  24  25  26  13  14
 REPEAT    1   29  30  31  32  33  34  35  36  37  38  39  40  41  42  43  44
            1   45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
            1   61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76
            1   77  78  79  80  81  82
            2    26.6000  -18.1300   26.6000  -16.1700
            2    29.8900  -16.1700   29.8900  -18.1300
            2  4
 ORIGINAL  2   28
 REPEAT    2   83  84  85

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