KEGG   DRUG: Perampanel hydrate
Entry
D10780                      Drug                                   
Name
Perampanel hydrate (JAN);
Fycompa (TN)
Product
FYCOMPA (Catalyst Pharmaceuticals), FYCOMPA (Eisai)
Formula
(C23H15N3O)4. 3H2O
Exact mass
1450.5177
Mol weight
1451.5846
Structure
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG01569  AMPA receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 1139
ATC code: N03AX22
Chemical structure group: DG01901
Product (DG01901): D10780<JP/US>
Efficacy
Antiepileptic, AMPA receptor antagonist
Target
GRIA [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX22 Perampanel
      D10780  Perampanel hydrate (JAN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Anticonvulsants, Other
   Perampanel
    D10780  Perampanel hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D10780  Perampanel hydrate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG01569  AMPA receptor antagonist
    DG01901  Perampanel
     D10780  Perampanel hydrate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01901  Perampanel
    D10780  Perampanel hydrate
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D10780  Perampanel hydrate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), non-NMDA
    GRIA
     D10780  Perampanel hydrate (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10780
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10780
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10780
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10780
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10780
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG01569  AMPA receptor antagonist
    DG01901  Perampanel
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01901  Perampanel
Other DBs
CAS: 1571982-04-1
PubChem: 313046638
LinkDB
KCF data

ATOM        111
            1   C8x C    10.7679  -12.1692
            2   C8x C    10.7679  -13.5679
            3   C8y C    12.0267  -14.2673
            4   C8y C    13.2157  -13.5679
            5   C8x C    13.2157  -12.1692
            6   C8x C    12.0267  -11.4698
            7   C8y C    14.4746  -14.3372
            8   C8x C    14.4746  -15.7360
            9   C8y C    15.6635  -16.4354
            10  C8x C    16.8525  -15.7360
            11  N4y N    16.8525  -14.3372
            12  C8y C    15.6635  -13.6379
            13  C3b C    12.0267  -15.7360
            14  N3a N    12.0267  -17.1348
            15  C8y C    18.1114  -13.6379
            16  C8x C    19.3003  -14.2673
            17  C8x C    20.4893  -13.5679
            18  C8x C    20.4893  -12.1692
            19  C8x C    19.3003  -11.4698
            20  C8x C    18.1114  -12.1692
            21  C8y C    15.6635  -17.8342
            22  N5x N    14.4746  -18.4636
            23  C8x C    14.4746  -19.8624
            24  C8x C    15.6635  -20.5618
            25  C8x C    16.8525  -19.9323
            26  C8x C    16.8525  -18.5335
            27  O5x O    15.6635  -12.1692
            28  O0  O    25.6900  -16.6600
            29  C8x C    10.7679  -12.1692
            30  C8x C    10.7679  -13.5679
            31  C8y C    12.0267  -14.2673
            32  C8y C    13.2157  -13.5679
            33  C8x C    13.2157  -12.1692
            34  C8x C    12.0267  -11.4698
            35  C8y C    14.4746  -14.3372
            36  C8x C    14.4746  -15.7360
            37  C8y C    15.6635  -16.4354
            38  C8x C    16.8525  -15.7360
            39  N4y N    16.8525  -14.3372
            40  C8y C    15.6635  -13.6379
            41  O5x O    15.6635  -12.1692
            42  C8y C    18.1114  -13.6379
            43  C8x C    19.3003  -14.2673
            44  C8x C    20.4893  -13.5679
            45  C8x C    20.4893  -12.1692
            46  C8x C    19.3003  -11.4698
            47  C8x C    18.1114  -12.1692
            48  C8y C    15.6635  -17.8342
            49  N5x N    14.4746  -18.4636
            50  C8x C    14.4746  -19.8624
            51  C8x C    15.6635  -20.5618
            52  C8x C    16.8525  -19.9323
            53  C8x C    16.8525  -18.5335
            54  C3b C    12.0267  -15.7360
            55  N3a N    12.0267  -17.1348
            56  C8x C    10.7679  -12.1692
            57  C8x C    10.7679  -13.5679
            58  C8y C    12.0267  -14.2673
            59  C8y C    13.2157  -13.5679
            60  C8x C    13.2157  -12.1692
            61  C8x C    12.0267  -11.4698
            62  C8y C    14.4746  -14.3372
            63  C8x C    14.4746  -15.7360
            64  C8y C    15.6635  -16.4354
            65  C8x C    16.8525  -15.7360
            66  N4y N    16.8525  -14.3372
            67  C8y C    15.6635  -13.6379
            68  O5x O    15.6635  -12.1692
            69  C8y C    18.1114  -13.6379
            70  C8x C    19.3003  -14.2673
            71  C8x C    20.4893  -13.5679
            72  C8x C    20.4893  -12.1692
            73  C8x C    19.3003  -11.4698
            74  C8x C    18.1114  -12.1692
            75  C8y C    15.6635  -17.8342
            76  N5x N    14.4746  -18.4636
            77  C8x C    14.4746  -19.8624
            78  C8x C    15.6635  -20.5618
            79  C8x C    16.8525  -19.9323
            80  C8x C    16.8525  -18.5335
            81  C3b C    12.0267  -15.7360
            82  N3a N    12.0267  -17.1348
            83  C8x C    10.7679  -12.1692
            84  C8x C    10.7679  -13.5679
            85  C8y C    12.0267  -14.2673
            86  C8y C    13.2157  -13.5679
            87  C8x C    13.2157  -12.1692
            88  C8x C    12.0267  -11.4698
            89  C8y C    14.4746  -14.3372
            90  C8x C    14.4746  -15.7360
            91  C8y C    15.6635  -16.4354
            92  C8x C    16.8525  -15.7360
            93  N4y N    16.8525  -14.3372
            94  C8y C    15.6635  -13.6379
            95  O5x O    15.6635  -12.1692
            96  C8y C    18.1114  -13.6379
            97  C8x C    19.3003  -14.2673
            98  C8x C    20.4893  -13.5679
            99  C8x C    20.4893  -12.1692
            100 C8x C    19.3003  -11.4698
            101 C8x C    18.1114  -12.1692
            102 C8y C    15.6635  -17.8342
            103 N5x N    14.4746  -18.4636
            104 C8x C    14.4746  -19.8624
            105 C8x C    15.6635  -20.5618
            106 C8x C    16.8525  -19.9323
            107 C8x C    16.8525  -18.5335
            108 C3b C    12.0267  -15.7360
            109 N3a N    12.0267  -17.1348
            110 O0  O    25.6900  -16.6600
            111 O0  O    25.6900  -16.6600
BOND        120
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 1
            13    7  12 1
            14    3  13 1
            15   13  14 3
            16   11  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23    9  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   12  27 2
            31   29  30 2
            32   30  31 1
            33   31  32 2
            34   32  33 1
            35   33  34 2
            36   29  34 1
            37   32  35 1
            38   35  36 2
            39   36  37 1
            40   37  38 2
            41   38  39 1
            42   39  40 1
            43   35  40 1
            44   31  54 1
            45   54  55 3
            46   39  42 1
            47   42  43 2
            48   43  44 1
            49   44  45 2
            50   45  46 1
            51   46  47 2
            52   42  47 1
            53   37  48 1
            54   48  49 2
            55   49  50 1
            56   50  51 2
            57   51  52 1
            58   52  53 2
            59   48  53 1
            60   40  41 2
            61   56  57 2
            62   57  58 1
            63   58  59 2
            64   59  60 1
            65   60  61 2
            66   56  61 1
            67   59  62 1
            68   62  63 2
            69   63  64 1
            70   64  65 2
            71   65  66 1
            72   66  67 1
            73   62  67 1
            74   58  81 1
            75   81  82 3
            76   66  69 1
            77   69  70 2
            78   70  71 1
            79   71  72 2
            80   72  73 1
            81   73  74 2
            82   69  74 1
            83   64  75 1
            84   75  76 2
            85   76  77 1
            86   77  78 2
            87   78  79 1
            88   79  80 2
            89   75  80 1
            90   67  68 2
            91   83  84 2
            92   84  85 1
            93   85  86 2
            94   86  87 1
            95   87  88 2
            96   83  88 1
            97   86  89 1
            98   89  90 2
            99   90  91 1
            100  91  92 2
            101  92  93 1
            102  93  94 1
            103  89  94 1
            104  85 108 1
            105 108 109 3
            106  93  96 1
            107  96  97 2
            108  97  98 1
            109  98  99 2
            110  99 100 1
            111 100 101 2
            112  96 101 1
            113  91 102 1
            114 102 103 2
            115 103 104 1
            116 104 105 2
            117 105 106 1
            118 106 107 2
            119 102 107 1
            120  94  95 2
BRACKET     1    10.0800  -21.0700   10.0800  -10.8500
            1    20.9300  -10.8500   20.9300  -21.0700
            1  4
 ORIGINAL  1    1   2   3   4   5   6   7   8   9  10  11  12  27  15  16  17
            1   18  19  20  21  22  23  24  25  26  13  14
 REPEAT    1   29  30  31  32  33  34  35  36  37  38  39  40  41  42  43  44
            1   45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60
            1   61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76
            1   77  78  79  80  81  82  83  84  85  86  87  88  89  90  91  92
            1   93  94  95  96  97  98  99 100 101 102 103 104 105 106 107 108
            1  109
            2    23.5200  -17.6400   23.5200  -15.5400
            2    26.6700  -15.5400   26.6700  -17.6400
            2  3
 ORIGINAL  2   28
 REPEAT    2  110 111

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