KEGG   DRUG: Fentanyl hydrochlorideHelp
Entry
D10811                      Drug                                   

Name
Fentanyl hydrochloride (JAN);
Ionsys (TN)
Product
Formula
C22H28N2O. HCl
Exact mass
372.1968
Mol weight
372.9315
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
ATC code: N01AH01 N02AB03
Chemical structure group: DG00791
Product (DG00791): D00320<JP/US> D01399<JP/US> D10811<US>
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH01 Fentanyl
      D10811  Fentanyl hydrochloride (JAN) <US>
  N02 ANALGESICS
   N02A OPIOIDS
    N02AB Phenylpiperidine derivatives
     N02AB03 Fentanyl
      D10811  Fentanyl hydrochloride (JAN) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D10811  Fentanyl hydrochloride (JAN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10811
BRITE hierarchy
Other DBs
CAS: 1443-54-5
PubChem: 319075071
ChEMBL: CHEMBL1201159
LinkDB All DBs
KCF data Show

ATOM        26
            1   N1c N    15.6081  -14.7682
            2   C1y C    16.8680  -15.4682
            3   C8y C    14.4183  -15.4682
            4   C5a C    15.6081  -13.3684
            5   C1x C    16.8680  -16.8680
            6   C1x C    18.0579  -14.7682
            7   C8x C    13.2284  -14.7682
            8   C8x C    14.4183  -16.8680
            9   C1b C    16.8680  -12.6685
            10  O5a O    14.4183  -12.6685
            11  C1x C    18.0579  -17.5679
            12  C1x C    19.2477  -15.4682
            13  C8x C    11.9686  -15.4682
            14  C8x C    13.1584  -17.5679
            15  C1a C    18.0579  -13.3684
            16  N1y N    19.2477  -16.8680
            17  C8x C    11.9686  -16.7980
            18  C1b C    20.5076  -17.5679
            19  C1b C    21.6974  -16.8680
            20  C8y C    22.8873  -17.5679
            21  C8x C    22.8873  -18.9677
            22  C8x C    24.1471  -16.8680
            23  C8x C    24.1471  -19.6677
            24  C8x C    25.3370  -17.5679
            25  C8x C    25.3370  -18.9677
            26  X   Cl   24.5000  -13.7900
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13    8  14 2
            14    9  15 1
            15   11  16 1
            16   13  17 2
            17   16  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 2
            23   22  24 1
            24   23  25 1
            25   12  16 1
            26   14  17 1
            27   24  25 2

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