KEGG   DRUG: Sofosbuvir and velpatasvirHelp
Entry
D10827            Mixture   Drug                                   

Name
Sofosbuvir and velpatasvir;
Epclusa (TN)
Product
  Generic
Component
Sofosbuvir [DR:D10366], Velpatasvir [DR:D10806]
Remark
Therapeutic category: 6250
ATC code: J05AP55
Product: D10827<JP/US>
Efficacy
Antiviral
  Disease
Hepatitis C virus infection [DS:H00413]
Comment
Sofosbuvir and Velpatasvir are substrates of BCRP and P-gp.
Velpatasvir is metabolized by CYP2B6, CYP2C8 and CYP3A4, and it is an inhibitor of the following transporters: P-gp, BCRP, OATP1B1 and OATP1B3.
Metabolism
Enzyme: CYP2B6 [HSA:1555], CYP2C8 [HSA:1558], CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Transporter inhibition: ABCB1 [HSA:5243], ABCG2 [HSA:9429], SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AP Antivirals for treatment of HCV infections
     J05AP55 Sofosbuvir and velpatasvir
      D10827  Sofosbuvir and velpatasvir <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis C (HCV) Agents, Direct Acting
   Sofosbuvir/Velpatasvir
    D10827  Sofosbuvir and velpatasvir
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10827  Sofosbuvir and velpatasvir
Antiinfectives [br08350.html]
 Antivirals
  D10827
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10827
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10827
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10827
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10827
BRITE hierarchy
Other DBs
PubChem: 319902627
LinkDB All DBs

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