KEGG   DRUG: Ribociclib succinate
Entry
D10979                      Drug                                   
Name
Ribociclib succinate (USAN);
Kisqali (TN)
Product
KISQALI (Novartis Pharmaceuticals Corporation)
Formula
C23H30N8O. C4H6O4
Exact mass
552.2809
Mol weight
552.6253
Structure
Simcomp
Class
Antineoplastic
 DG03138  CDK inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: L01EF02
Chemical structure group: DG02084
Product (DG02084): D10979<US>
Product (mixture): D11068<US>
Efficacy
Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor
  Disease
Breast cancer (HR-positive, HER2-negative) [DS:H00031]
Target
CDK4/6 [HSA:1019 1021] [KO:K02089 K02091]
  Pathway
hsa04110  Cell cycle
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05224  Breast cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EF Cyclin-dependent kinase (CDK) inhibitors
     L01EF02 Ribociclib
      D10979  Ribociclib succinate (USAN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Ribociclib
    D10979  Ribociclib succinate (USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG03138  CDK inhibitor
   DG02084  Ribociclib
    D10979  Ribociclib succinate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG02084  Ribociclib
     D10979  Ribociclib succinate
Drug classes [BR:br08332]
 Antineoplastic
  DG03138  CDK inhibitor
   D10979  Ribociclib succinate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CMGC group
    CDK4/6
     D10979  Ribociclib succinate (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10979
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10979
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10979
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10979
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D10979
Drug groups [BR:br08330]
 Antineoplastic
  DG03138  CDK inhibitor
   DG02084  Ribociclib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG02084  Ribociclib
Other DBs
CAS: 1374639-75-4
PubChem: 342581823
LinkDB
KCF data

ATOM        40
            1   N5x N    18.4296  -14.9311
            2   C8y C    18.4296  -16.3336
            3   N5x N    17.2375  -17.0349
            4   C8y C    15.9752  -16.3336
            5   C8y C    15.9752  -14.9311
            6   C8x C    17.2375  -14.2298
            7   N4y N    14.6427  -16.7544
            8   C8y C    13.8713  -15.6323
            9   C8x C    14.6427  -14.5103
            10  N1b N    19.6218  -17.0349
            11  C8y C    20.8140  -16.3336
            12  C8x C    20.8140  -14.9311
            13  C8x C    22.0763  -14.2298
            14  C8y C    23.2685  -14.9311
            15  C8x C    23.2685  -16.3336
            16  N5x N    22.0763  -17.0349
            17  N1y N    24.4607  -14.2298
            18  C1x C    24.4607  -12.8272
            19  C1x C    25.7230  -12.1259
            20  N1x N    26.9152  -12.8272
            21  C1x C    26.9152  -14.2298
            22  C1x C    25.7230  -14.9311
            23  C5a C    12.4687  -15.6323
            24  C1y C    14.2219  -18.0868
            25  C1x C    15.0635  -19.2089
            26  C1x C    14.2219  -20.3309
            27  C1x C    12.8895  -19.9102
            28  C1x C    12.8895  -18.5076
            29  O5a O    11.7674  -16.8245
            30  N1c N    11.7674  -14.4402
            31  C1a C    10.3649  -14.4402
            32  C1a C    12.4687  -13.2480
            33  O6a O    27.5100  -18.8300
            34  C6a C    28.7224  -18.1300
            35  C1b C    29.9349  -18.8300
            36  C1b C    31.1473  -18.1300
            37  C6a C    32.3597  -18.8300
            38  O6a O    33.5722  -18.1300
            39  O6a O    28.7224  -16.7302
            40  O6a O    32.3597  -20.2299
BOND        43
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    2  10 1
            12   10  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   11  16 1
            19   14  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   17  22 1
            26    8  23 1
            27    7  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   24  28 1
            33   23  29 2
            34   23  30 1
            35   30  31 1
            36   30  32 1
            37   33  34 1
            38   34  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   34  39 2
            43   37  40 2

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