KEGG   ORTHOLOGY: K02089
Entry
K02089                      KO                                     
Symbol
CDK4
Name
cyclin-dependent kinase 4 [EC:2.7.11.22]
Pathway
map01522  Endocrine resistance
map04110  Cell cycle
map04115  p53 signaling pathway
map04151  PI3K-Akt signaling pathway
map04218  Cellular senescence
map04530  Tight junction
map04660  T cell receptor signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map04934  Cushing syndrome
map05160  Hepatitis C
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05212  Pancreatic cancer
map05214  Glioma
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05222  Small cell lung cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
Disease
H00030  Cervical cancer
H00038  Melanoma
H00042  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02089  CDK4; cyclin-dependent kinase 4
   04115 p53 signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
   04218 Cellular senescence
    K02089  CDK4; cyclin-dependent kinase 4
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K02089  CDK4; cyclin-dependent kinase 4
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05203 Viral carcinogenesis
    K02089  CDK4; cyclin-dependent kinase 4
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05225 Hepatocellular carcinoma
    K02089  CDK4; cyclin-dependent kinase 4
   05214 Glioma
    K02089  CDK4; cyclin-dependent kinase 4
   05220 Chronic myeloid leukemia
    K02089  CDK4; cyclin-dependent kinase 4
   05218 Melanoma
    K02089  CDK4; cyclin-dependent kinase 4
   05219 Bladder cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05224 Breast cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05222 Small cell lung cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05223 Non-small cell lung cancer
    K02089  CDK4; cyclin-dependent kinase 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02089  CDK4; cyclin-dependent kinase 4
   05160 Hepatitis C
    K02089  CDK4; cyclin-dependent kinase 4
   05164 Influenza A
    K02089  CDK4; cyclin-dependent kinase 4
   05162 Measles
    K02089  CDK4; cyclin-dependent kinase 4
   05163 Human cytomegalovirus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05169 Epstein-Barr virus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05165 Human papillomavirus infection
    K02089  CDK4; cyclin-dependent kinase 4
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02089  CDK4; cyclin-dependent kinase 4
   04934 Cushing syndrome
    K02089  CDK4; cyclin-dependent kinase 4
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K02089  CDK4; cyclin-dependent kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02089  CDK4; cyclin-dependent kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02089  CDK4; cyclin-dependent kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02089  CDK4; cyclin-dependent kinase 4
Other DBs
GO: 0004693
Genes
HSA: 1019(CDK4)
PTR: 452025(CDK4)
PPS: 100976294(CDK4)
GGO: 101147065(CDK4)
PON: 100443314(CDK4)
NLE: 100594967(CDK4)
HMH: 116480850(CDK4)
MCC: 715650(CDK4)
MCF: 101925733(CDK4)
MTHB: 126930400
MNI: 105474081(CDK4)
CSAB: 103238589(CDK4)
CATY: 105587240(CDK4)
PANU: 101011004(CDK4)
TGE: 112634055(CDK4)
MLEU: 105545589(CDK4)
RRO: 104682344(CDK4)
RBB: 108524397(CDK4)
TFN: 117089862(CDK4)
PTEH: 111541790(CDK4)
CANG: 105500487(CDK4)
CJC: 100408304(CDK4)
SBQ: 101040767(CDK4)
CIMI: 108304334 108309741(CDK4) 108313247
CSYR: 103264423(CDK4)
MMUR: 105877995(CDK4)
LCAT: 123639589(CDK4)
PCOQ: 105816738(CDK4)
OGA: 100960589(CDK4)
MMU: 12567(Cdk4)
MCAL: 110303132(Cdk4)
MPAH: 110326196(Cdk4)
RNO: 94201(Cdk4)
MCOC: 116075684(Cdk4)
ANU: 117696408(Cdk4)
MUN: 110561245(Cdk4)
CGE: 100760122(Cdk4)
MAUA: 101839492(Cdk4)
PROB: 127215685(Cdk4)
PLEU: 114704814(Cdk4)
MORG: 121461982 121463961(Cdk4)
MFOT: 126514774
AAMP: 119803317(Cdk4)
NGI: 103742900(Cdk4)
HGL: 101702608(Cdk4)
CPOC: 100717960(Cdk4)
CCAN: 109686224(Cdk4)
DORD: 105989896(Cdk4)
DSP: 122124085(Cdk4)
NCAR: 124983907
OCU: 100009039
OPI: 101530437(CDK4)
TUP: 102493291(CDK4)
GVR: 103609174(CDK4)
CFA: 481131(CDK4) 612475
CLUD: 112654545 112677962(CDK4)
VVP: 112922331(CDK4)
VLG: 121490703(CDK4)
AML: 100481236(CDK4)
UMR: 103656694(CDK4)
UAH: 113256363(CDK4)
UAR: 123787201(CDK4)
ELK: 111160230
LLV: 125106397
MPUF: 101673063(CDK4)
NVS: 122892356(CDK4)
ORO: 101362330(CDK4)
EJU: 114214999(CDK4)
ZCA: 113921783(CDK4)
MLX: 118008659(CDK4)
NSU: 110577858(CDK4)
LWW: 102746891(CDK4)
FCA: 101097903(CDK4)
PYU: 121040857(CDK4)
PBG: 122473830(CDK4)
LRUF: 124501159
PTG: 102970281(CDK4)
PPAD: 109270390(CDK4)
PUC: 125919257
AJU: 106975871(CDK4)
HHV: 120248012(CDK4)
BTA: 510618(CDK4)
BOM: 102278545(CDK4)
BIU: 109559308(CDK4)
BBUB: 102412787(CDK4)
BBIS: 104988133(CDK4)
CHX: 102171306(CDK4)
OAS: 100144756(CDK4)
ODA: 120857506(CDK4)
CCAD: 122427215(CDK4)
SSC: 100144492(CDK4)
CFR: 102522300(CDK4)
CBAI: 105062140(CDK4)
CDK: 105100330(CDK4)
VPC: 102532580(CDK4)
BACU: 103000540(CDK4) 103010593
LVE: 103084826(CDK4)
OOR: 101283760(CDK4)
DLE: 111173824(CDK4)
PCAD: 102985179(CDK4)
PSIU: 116760381(CDK4)
NASI: 112394295(CDK4)
ECB: 100051005(CDK4)
EPZ: 103553644(CDK4)
EAI: 106833016(CDK4)
MYB: 102261527(CDK4)
MYD: 102758995(CDK4)
MMYO: 118651037(CDK4)
MLF: 102431798(CDK4)
MNA: 107546223(CDK4)
PKL: 118730275(CDK4)
HAI: 109390747(CDK4)
DRO: 112319119(CDK4)
SHON: 118975891(CDK4)
AJM: 119065244(CDK4)
PDIC: 114512697(CDK4)
PHAS: 123812897(CDK4)
MMF: 118624208(CDK4)
RFQ: 117029166(CDK4)
PALE: 102894222(CDK4)
PGIG: 120604974(CDK4)
PVP: 105307393(CDK4)
RAY: 107501504(CDK4)
MJV: 108387631(CDK4)
TOD: 119248102(CDK4)
SARA: 101559274(CDK4)
LAV: 104847103(CDK4)
TMU: 101355276
ETF: 101654378(CDK4)
DNM: 101416305(CDK4)
GAS: 123251284(CDK4)
SHR: 100932899(CDK4)
AFZ: 127538222
PCW: 110210989(CDK4)
CJO: 107325825(CDK4)
PHI: 102103942(CDK4)
PMAJ: 107199280
SVG: 106862647(CDK4)
TALA: 116960867 116963701(CDK4)
AGEN: 126037403
AAM: 106492770
NPD: 112952245(CDK4)
DNE: 112983405(CDK4)
ASN: 102387479(CDK4)
AMJ: 102572556(CDK4)
CPOO: 109324458(CDK4)
CMY: 102945436(CDK4)
CPIC: 101943854(CDK4)
TST: 117888590(CDK4)
CABI: 116828541(CDK4)
MRV: 120391006(CDK4)
ACS: 100559515(cdk4)
PVT: 110074435(CDK4)
SUND: 121920842(CDK4)
PBI: 103058869(CDK4)
PMUR: 107291540(CDK4)
CTIG: 120309963(CDK4)
TSR: 106540822(CDK4)
PGUT: 117662680(CDK4)
VKO: 123029774(CDK4)
PMUA: 114593035(CDK4)
ZVI: 118078968(CDK4)
GJA: 107119665(CDK4)
XLA: 379406(cdk4.S) 496334(cdk6.L)
XTR: 549496(cdk4)
NPR: 108795357(CDK4)
RTEM: 120929442(CDK4)
BBUF: 120996181(CDK4)
BGAR: 122932515(CDK4)
DRE: 777730(cdk4)
SRX: 107737134 107747701
SANH: 107684003 107701179
SGH: 107567936
CCAR: 109069976 109089968
CAUA: 113054912 113068151
CGIB: 127968260 128022703
PPRM: 120460707(cdk4)
MAMB: 125256866(cdk4)
CIDE: 127522801
MASI: 127425969
IPU: 108255186(cdk4)
PHYP: 113525662
SMEO: 124401943(cdk4)
TFD: 113639050(cdk4)
AMEX: 103034254(cdk4)
EEE: 113572459(cdk4)
TRU: 101063081(cdk4)
TNG: GSTEN00033818G001
LCO: 104929049(cdk4)
NCC: 104955917(cdk4)
CGOB: 115008789(cdk4)
ELY: 117257485(cdk4)
EFO: 125893517(cdk4)
PLEP: 121953305(cdk4)
SLUC: 116066212(cdk4)
ECRA: 117942897(cdk4)
ESP: 116679825 116687243
PFLV: 114554047(cdk4)
GAT: 120835334(cdk4)
PPUG: 119194053(cdk4)
MSAM: 119886384(cdk4)
CUD: 121507439(cdk4)
ALAT: 119020857(cdk4)
MZE: 101475315
ONL: 100710125(cdk4)
OAU: 116326635(cdk4)
OLA: 101172808(cdk4)
OML: 112145080(cdk4)
XMA: 102220323(cdk4)
XCO: 114135419(cdk4)
XHE: 116710170(cdk4)
PRET: 103465328(cdk4)
PFOR: 103129587(cdk4)
PLAI: 106961113
PMEI: 106923269
GAF: 122833741(cdk4)
CVG: 107082148(cdk4)
CTUL: 119795488(cdk4)
GMU: 124856981
NFU: 107385649(cdk4)
KMR: 108235797(cdk4)
ALIM: 106518078
NWH: 119412589(cdk4)
AOCE: 111587634(cdk4)
MCEP: 125007293(cdk4)
CSEM: 103386052(cdk4)
POV: 109629352(cdk4)
SSEN: 122768740(cdk4)
HHIP: 117761425(cdk4)
HSP: 118104894(cdk4)
LCF: 108898964
SDU: 111221753(cdk4)
SLAL: 111667889(cdk4)
XGL: 120807598(cdk4)
HCQ: 109522590(cdk4)
SSCV: 125976797
BPEC: 110171259(cdk4)
MALB: 109956190(cdk4)
BSPL: 114855460(cdk4)
SASA: 106565448 106583286
STRU: 115150473 115207950
OTW: 112216345(cdk4) 112254694
OMY: 110494214 110528217
OGO: 124003111 124031204
ONE: 115140953 115143085
SALP: 111965632 111970188 111970190
SNH: 120062000 120065264
CCLU: 121575165 121577842
ELS: 105016970(cdk4)
SFM: 108918175(cdk4)
PKI: 111854375(cdk4) 111856032
AANG: 118210620(cdk4)
LOC: 102686530(cdk4)
PSPA: 121308988(cdk4)
ARUT: 117401103 117962597
PSEX: 120524842(cdk4)
LCM: 102363370(CDK4)
CMK: 103191316(cdk4)
RTP: 109925336(cdk4)
CPLA: 122543277(cdk4)
AJC: 117108070
DME: Dmel_CG5072(Cdk4)
DER: 6548425
DSE: 6609465
DSI: Dsimw501_GD11207(Dsim_GD11207)
DYA: Dyak_GE11805
DAN: 6494260
DSR: 110187091
DPO: 4803571
DPE: 6591061
DMN: 108158559 117191375 117191615 117191617
DWI: 6639792
DGR: 6559243
DMO: Dmoj_GI20474
DAZ: 108615638
DNV: 108653601
DHE: 111593550
DVI: 6625181
CCAT: 101454916
BOD: 106621434
RZE: 108365867
MDE: 101892496
SCAC: 106086684
LCQ: 111675356
LSQ: 119603043
HIS: 119646348
AGA: AgaP_AGAP005817
ACOZ: 120947623
AARA: 120905759
ASTE: 118511494
AAG: 5570506
AALB: 109406441
CQU: CpipJ_CPIJ015895
CPII: 120425591
CNS: 116345736
BCOO: 119079833
BIM: 100740274
CCAL: 108633063
SOC: 105196992
MPHA: 105838129
AEC: 105153633
PBAR: 105433444
VEM: 105561026
HST: 105187057
DQU: 106744310
CFO: 105249672
FEX: 115233314
LHU: 105675373
PGC: 109855281
PCF: 106790376
NVI: 100122192(Cdk4)
CSOL: 105361031
TPRE: 106648062
TCA: 663975
DPA: 109545808
SOY: 115875203
ATD: 109601734 109602185
AGB: 108914646
LDC: 111502212
NVL: 108558807
PPYR: 116159688
OTU: 111413066
BMOR: 100316860
BMAN: 114250235
MSEX: 115444537
DPL: KGM_201733 KGM_201734
BANY: 112056244
NIQ: 126779296
PMAC: 106709519
PPOT: 106101314
PXU: 106124670
PRAP: 110993439
PBX: 123718879
PNAP: 125062674
ZCE: 119836525
CCRC: 123704180
HAW: 110381856
HZE: 124643481
TNL: 113499972
SLIU: 111350035
OFU: 114359631
PXY: 105389917
CFEL: 113389462
PJA: 122253490
PCLA: 123759664
SDM: 118180084
LOA: LOAG_17283
TSP: Tsp_00762
AOR: AO090026000290
 » show all
Reference
PMID:18414028
  Authors
Blain SW
  Title
Switching cyclin D-Cdk4 kinase activity on and off.
  Journal
Cell Cycle 7:892-8 (2008)
DOI:10.4161/cc.7.7.5637
Reference
PMID:7652577
  Authors
Wolfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Buschenfelde KH, Beach D
  Title
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.
  Journal
Science 269:1281-4 (1995)
DOI:10.1126/science.7652577
  Sequence
[hsa:1019]
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