KEGG   DRUG: Ertugliflozin pidolateHelp
Entry
D11043                      Drug                                   

Name
Ertugliflozin pidolate;
Steglatro (TN)
Product
Formula
C22H25ClO7. C5H7NO3
Exact mass
565.1715
Mol weight
565.9967
Structure
Mol fileKCF fileDB search
Class
Antidiabetic agent
 DG01794  SGLT2 inhibitor
 DG02044  Hypoglycemics
  DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
ATC code: A10BK04
Chemical structure group: DG02836
Product (DG02836): D11043<US>
Product (mixture): D11066<US> D11067<US>
Efficacy
Antidiabetic, SGLT-2 inhibitor
  Disease
Type 2 diabetes mellitus [DS:H00409]
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: UGT1A9 [HSA:54600], UGT2B7 [HSA:7364]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
     A10BK04 Ertugliflozin
      D11043  Ertugliflozin pidolate <US>
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D11043  Ertugliflozin pidolate <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11043
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11043
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11043
BRITE hierarchy
Other DBs
CAS: 1210344-83-4
PubChem: 355052577
LinkDB All DBs
KCF data Show

ATOM        39
            1   C8y C    15.7761  -17.5990
            2   C8x C    15.7761  -18.9312
            3   C8x C    16.8979  -19.5622
            4   C8y C    18.0899  -18.9312
            5   C8y C    18.0899  -17.5990
            6   C8x C    16.8979  -16.8978
            7   C1b C    19.2818  -16.8978
            8   C8y C    20.4738  -17.5990
            9   C8x C    20.4738  -18.9312
            10  C8x C    21.5957  -19.5622
            11  C8y C    22.7175  -18.9312
            12  C8x C    22.7175  -17.5990
            13  C8x C    21.5957  -16.8978
            14  X   Cl   19.2818  -19.5622
            15  O2a O    23.9095  -19.5622
            16  C1b C    25.0313  -18.9312
            17  C1a C    26.1532  -19.5622
            18  C1z C    14.5841  -16.8978
            19  O2x O    14.5841  -15.5656
            20  C1z C    13.3922  -14.8645
            21  C1y C    12.2703  -15.5656
            22  C1y C    12.2703  -16.8978
            23  C1y C    13.3922  -17.5990
            24  O1a O    13.3922  -18.9312
            25  O1a O    11.0783  -14.8645
            26  O1a O    11.0783  -17.5990
            27  C1b C    13.3922  -13.5323
            28  O1a O    14.5841  -12.8311
            29  C1x C    14.8646  -14.0231
            30  O2x O    16.2669  -15.9162
            31  C5x C    29.7178  -15.4386
            32  C1x C    30.1370  -16.7660
            33  C1x C    31.5343  -16.7659
            34  C1y C    32.0234  -15.5084
            35  N1x N    30.9055  -14.6700
            36  C6a C    33.2111  -14.7399
            37  O6a O    34.3988  -15.4386
            38  O6a O    33.2111  -13.3426
            39  O5x O    28.3903  -15.0194
BOND        42
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    4  14 1
            16   11  15 1
            17   15  16 1
            18   16  17 1
            19   18   1 1 #Up
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   18  23 1
            26   23  24 1 #Down
            27   21  25 1 #Down
            28   22  26 1 #Up
            29   20  27 1 #Up
            30   27  28 1
            31   20  29 1 #Down
            32   18  30 1 #Down
            33   29  30 1
            34   31  32 1
            35   32  33 1
            36   33  34 1
            37   34  35 1
            38   31  35 1
            39   34  36 1 #Down
            40   36  37 1
            41   36  38 2
            42   31  39 2

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