KEGG   DRUG: Vericiguat
Entry
D11051                      Drug                                   

Name
Vericiguat (JAN/USAN/INN);
Verquvo (TN)
Product
Formula
C19H16F2N8O2
Exact mass
426.1364
Mol weight
426.3795
Structure
Simcomp
Class
Cardiovascular agent
 DG03006  Guanylate cyclase activator
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03183  UGT1A1 substrate
  DG03188  UGT1A9 substrate
Remark
Therapeutic category: 2190
ATC code: C01DX22
Product: D11051<JP/US>
Efficacy
Vasodilator, Guanylate cyclase activator
Target
GUCY1A [HSA:2977 2982] [KO:K12318]
GUCY1B [HSA:2983] [KO:K12319]
  Pathway
hsa04270  Vascular smooth muscle contraction
hsa04611  Platelet activation
Metabolism
Enzyme: UGT1A9 [HSA:54600]; UGT1A1 [HSA:54658]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DX Other vasodilators used in cardiac diseases
     C01DX22 Vericiguat
      D11051  Vericiguat (JAN/USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D11051  Vericiguat (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Phosphorus-oxygen lyases
    GUCY1A
     D11051  Vericiguat (JAN/USAN/INN) <JP/US>
    GUCY1B
     D11051  Vericiguat (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11051
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11051
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11051
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11051
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11051
Other DBs
CAS: 1350653-20-1
PubChem: 363669764
ChEBI: 142432
ChEMBL: CHEMBL4066936
LinkDB
KCF data

ATOM        31
            1   N5x N    19.1549  -13.7534
            2   C8y C    19.1549  -15.1568
            3   N5x N    20.3477  -15.8584
            4   C8y C    21.6106  -15.1568
            5   C8y C    21.6106  -13.7534
            6   C8y C    20.3477  -13.0519
            7   N1a N    20.3477  -11.6485
            8   N1b N    22.8034  -13.0519
            9   N1a N    22.8034  -15.8584
            10  C7a C    23.9962  -13.7534
            11  O7a O    25.1890  -13.0519
            12  O6a O    23.9962  -15.1568
            13  C1a C    26.3818  -13.7534
            14  C8y C    17.9621  -15.8584
            15  N4y N    15.7169  -15.9285
            16  C8y C    16.1378  -17.1915
            17  C8y C    17.5411  -17.1915
            18  N5x N    16.8395  -15.0165
            19  N5x N    15.5064  -18.4545
            20  C8x C    16.2080  -19.6473
            21  C8y C    17.6112  -19.6473
            22  C8x C    18.3129  -18.3843
            23  C1b C    14.5241  -15.2269
            24  C8y C    13.3312  -15.9285
            25  C8x C    12.1384  -15.2269
            26  C8x C    10.8755  -15.9285
            27  C8x C    10.8755  -17.3319
            28  C8x C    12.0683  -18.0334
            29  C8y C    13.3312  -17.3319
            30  X   F    14.5241  -18.0334
            31  X   F    18.3013  -20.8204
BOND        34
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     6   7 1
            8     5   8 1
            9     4   9 1
            10    8  10 1
            11   10  11 1
            12   10  12 2
            13   11  13 1
            14    2  14 1
            15   15  16 1
            16   16  17 2
            17   17  14 1
            18   14  18 2
            19   15  18 1
            20   16  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   23  15 1
            26   23  24 1
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   24  29 2
            33   29  30 1
            34   21  31 1

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