KEGG   DRUG: Vericiguat
Entry
D11051                      Drug                                   

Name
Vericiguat (JAN/USAN/INN);
Verquvo (TN)
Product
Formula
C19H16F2N8O2
Exact mass
426.1364
Mol weight
426.3795
Structure
Simcomp
Remark
ATC code: C01DX22
Product: D11051<US>
Efficacy
Vasodilator, Guanylate cyclase activator
Target
GUCY1A [HSA:2977 2982] [KO:K12318]
GUCY1B [HSA:2983] [KO:K12319]
  Pathway
hsa04270  Vascular smooth muscle contraction
hsa04611  Platelet activation
Metabolism
Enzyme: UGT1A9 [HSA:54600]; UGT1A1 [HSA:54658]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DX Other vasodilators used in cardiac diseases
     C01DX22 Vericiguat
      D11051  Vericiguat (JAN/USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Phosphorus-oxygen lyases
    GUCY1A
     D11051  Vericiguat (JAN/USAN/INN) <US>
    GUCY1B
     D11051  Vericiguat (JAN/USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11051
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11051
Other DBs
CAS: 1350653-20-1
PubChem: 363669764
ChEBI: 142432
ChEMBL: CHEMBL4066936
LinkDB
KCF data

ATOM        31
            1   N5x N    19.1549  -13.7534
            2   C8y C    19.1549  -15.1568
            3   N5x N    20.3477  -15.8584
            4   C8y C    21.6106  -15.1568
            5   C8y C    21.6106  -13.7534
            6   C8y C    20.3477  -13.0519
            7   N1a N    20.3477  -11.6485
            8   N1b N    22.8034  -13.0519
            9   N1a N    22.8034  -15.8584
            10  C7a C    23.9962  -13.7534
            11  O7a O    25.1890  -13.0519
            12  O6a O    23.9962  -15.1568
            13  C1a C    26.3818  -13.7534
            14  C8y C    17.9621  -15.8584
            15  N4y N    15.7169  -15.9285
            16  C8y C    16.1378  -17.1915
            17  C8y C    17.5411  -17.1915
            18  N5x N    16.8395  -15.0165
            19  N5x N    15.5064  -18.4545
            20  C8x C    16.2080  -19.6473
            21  C8y C    17.6112  -19.6473
            22  C8x C    18.3129  -18.3843
            23  C1b C    14.5241  -15.2269
            24  C8y C    13.3312  -15.9285
            25  C8x C    12.1384  -15.2269
            26  C8x C    10.8755  -15.9285
            27  C8x C    10.8755  -17.3319
            28  C8x C    12.0683  -18.0334
            29  C8y C    13.3312  -17.3319
            30  X   F    14.5241  -18.0334
            31  X   F    18.3013  -20.8204
BOND        34
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     6   7 1
            8     5   8 1
            9     4   9 1
            10    8  10 1
            11   10  11 1
            12   10  12 2
            13   11  13 1
            14    2  14 1
            15   15  16 1
            16   16  17 2
            17   17  14 1
            18   14  18 2
            19   15  18 1
            20   16  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   23  15 1
            26   23  24 1
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   24  29 2
            33   29  30 1
            34   21  31 1

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