KEGG   DRUG: Evocalcet
Entry
D11063                      Drug                                   
Name
Evocalcet (JAN/INN);
Orkedia (TN)
Formula
C24H26N2O2
Exact mass
374.1994
Mol weight
374.47
Structure
Remark
Therapeutic category: 3999
ATC code: H05BX06
Product: D11063<JP>
Efficacy
Antihyperparathyroidism, Calcium-sensing receptor agonist
Target
CASR [HSA:846] [KO:K04612]
  Pathway
hsa04621  NOD-like receptor signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
  Network
nt06318  CaSR-PTH signaling
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H05 CALCIUM HOMEOSTASIS
   H05B ANTI-PARATHYROID AGENTS
    H05BX Other anti-parathyroid agents
     H05BX06 Evocalcet
      D11063  Evocalcet (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D11063  Evocalcet (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Metabotropic glutamate receptor family
   Calcium-sensing
    CASR
     D11063  Evocalcet (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11063
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11063
Other DBs
CAS: 870964-67-3
PubChem: 363669775
PDB-CCD: H43[PDBj]
LinkDB
KCF data

ATOM        28
            1   C8x C    11.9700  -14.4200
            2   C8y C    11.9700  -15.8200
            3   C8y C    13.2300  -16.5200
            4   C8y C    14.4200  -15.8200
            5   C8x C    14.4200  -14.4200
            6   C8x C    13.2300  -13.7200
            7   C8x C    10.7800  -16.5200
            8   C8x C    10.7800  -17.9200
            9   C8x C    11.9700  -18.6200
            10  C8x C    13.2300  -17.9200
            11  C1c C    15.6800  -16.5200
            12  N1b N    16.8700  -15.8200
            13  C1y C    18.0600  -16.5200
            14  C1a C    15.6800  -17.9200
            15  C1x C    19.1800  -15.6800
            16  N1y N    20.3000  -16.5200
            17  C1x C    19.8800  -17.8500
            18  C1x C    18.4800  -17.8500
            19  C8y C    21.4900  -15.8200
            20  C8x C    21.4900  -14.4200
            21  C8x C    22.7500  -13.7200
            22  C8y C    23.9400  -14.4200
            23  C8x C    23.9400  -15.8200
            24  C8x C    22.7500  -16.5200
            25  C1b C    25.1300  -13.7200
            26  C6a C    26.3200  -14.4200
            27  O6a O    27.5100  -13.7200
            28  O6a O    26.3200  -15.8200
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    3  10 1
            12    4  11 1
            13   11  12 1
            14   13  12 1 #Down
            15   11  14 1 #Down
            16   13  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   13  18 1
            21   16  19 1
            22   19  20 2
            23   20  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   19  24 1
            28   22  25 1
            29   25  26 1
            30   26  27 1
            31   26  28 2

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