KEGG   DRUG: Fexinidazole
Entry
D11252                      Drug                                   

Name
Fexinidazole (USAN/INN);
Fexinidazole (TN)
Product
Formula
C12H13N3O3S
Exact mass
279.0678
Mol weight
279.3149
Structure
Class
Antiparasitic
 DG01884  Imidazole antiprotozoal
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: P01CA03
Product: D11252<US>
Efficacy
Antiparasitic
  Disease
African trypanosomiasis [DS:H00357]
Comment
Nitroimidazole derivative
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01C AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS
    P01CA Nitroimidazole derivatives
     P01CA03 Fexinidazole
      D11252  Fexinidazole (USAN/INN) <US>
Antimicrobials [BR:br08307]
 Antiparasitics
  Agents against Leishmaniasis and Trypanosomiasis
   Nitroimidazole derivatives
    D11252  Fexinidazole (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11252
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11252
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11252
Other DBs
CAS: 59729-37-2
PubChem: 384585230
ChEMBL: CHEMBL1631694
LinkDB
KCF data

ATOM        19
            1   N5x N    19.5817  -19.4830
            2   C8x C    20.0325  -20.8084
            3   C8y C    21.4324  -20.7893
            4   N4y N    21.8468  -19.4520
            5   C8y C    20.7030  -18.6447
            6   N2b N    22.1324  -22.0017 #+
            7   O3a O    23.1223  -22.9917
            8   O3a O    20.5700  -22.9817 #-
            9   C1a C    23.1637  -19.0041
            10  C1b C    20.7532  -17.2205
            11  O2a O    21.9636  -16.5770
            12  C8y C    21.9636  -15.1770
            13  C8x C    23.1826  -14.4732
            14  C8x C    23.1825  -13.0732
            15  C8y C    21.9700  -12.3733
            16  C8x C    20.7510  -13.0771
            17  C8x C    20.7511  -14.4771
            18  S2a S    21.9700  -10.9900
            19  C1a C    23.1899  -10.2857
BOND        20
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   5 2
            6     3   6 1
            7     6   7 2
            8     6   8 1
            9     4   9 1
            10    5  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   12  17 1
            19   15  18 1
            20   18  19 1

» Japanese version   » Back

DBGET integrated database retrieval system