KEGG   DRUG: Voxelotor
Entry
D11330                      Drug                                   

Name
Voxelotor (USAN);
Oxbryta (TN)
Product
Formula
C19H19N3O3
Exact mass
337.1426
Mol weight
337.3725
Structure
Remark
Product: D11330<US>
Efficacy
Anti-anemic, Hemoglobin S polymerization inhibitor
  Disease
Sickle cell disease [DS:H00229]
Comment
Treatment of sickle cell disease
Hemoglobin oxygen-affinity modulator
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2C19 [HSA:1557], CYP2B6 [HSA:1555], CYP2C9 [HSA:1559]
Interaction
Brite
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11330
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11330
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11330
Other DBs
CAS: 1446321-46-5
PubChem: 384585308
ChEMBL: CHEMBL4101807
LinkDB
KCF data

ATOM        25
            1   C8x C    10.6400  -17.5700
            2   C8x C    10.6400  -18.9700
            3   C8x C    11.8300  -19.6700
            4   C8y C    13.0900  -18.9700
            5   C8y C    13.0900  -17.5700
            6   N5x N    11.8300  -16.8700
            7   C1b C    14.2800  -19.6700
            8   O2a O    15.4700  -18.9700
            9   C8y C    16.6600  -19.6700
            10  C8x C    16.6600  -21.0700
            11  C8x C    17.9200  -21.7700
            12  C8x C    19.1100  -21.0700
            13  C8y C    19.1100  -19.6700
            14  C8y C    17.9200  -18.9700
            15  C4a C    17.9200  -17.5700
            16  O4a O    19.1100  -16.8700
            17  O1a O    20.3000  -18.9700
            18  C8y C    14.2800  -16.8700
            19  C8x C    15.6100  -17.2900
            20  C8x C    16.4500  -16.1700
            21  N5x N    15.6100  -15.0500
            22  N4y N    14.2800  -15.4700
            23  C1c C    13.0900  -14.7700
            24  C1a C    11.9000  -15.4700
            25  C1a C    13.0900  -13.3700
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   14  15 1
            17   15  16 2
            18   13  17 1
            19    5  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   18  22 1
            25   23  22 1
            26   23  24 1
            27   23  25 1

» Japanese version   » Back

DBGET integrated database retrieval system