KEGG   DRUG: Ripretinib
Entry
D11353                      Drug                                   
Name
Ripretinib (USAN);
Qinlock (TN)
Product
QINLOCK (Deciphera Pharmaceuticals)
Formula
C24H21BrFN5O2
Exact mass
509.0863
Mol weight
510.36
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
ATC code: L01EX19
Product: D11353<US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Gastrotintestinal stromal tumor [DS:H01591]
Target
KIT (CD117) [HSA:3815] [KO:K05091]
PDGFRA [HSA:5156] [KO:K04363]
  Pathway
hsa04072  Phospholipase D signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX19 Ripretinib
      D11353  Ripretinib (USAN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   PDGFR Alpha Inhibitors
    Ripretinib
     D11353  Ripretinib (USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    D11353  Ripretinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFRA
     D11353  Ripretinib (USAN) <US>
    KIT (CD117)
     D11353  Ripretinib (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11353
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11353
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11353
Other DBs
CAS: 1442472-39-0
PubChem: 384585331
LinkDB
KCF data

ATOM        33
            1   C8x C    22.9600  -15.9600
            2   C8x C    22.9600  -17.3600
            3   C8x C    21.7700  -18.0600
            4   C8y C    20.5100  -17.3600
            5   C8x C    20.5100  -15.9600
            6   C8x C    21.7700  -15.2600
            7   N1b N    19.3200  -18.0600
            8   C5a C    18.1300  -17.3600
            9   N1b N    16.9400  -18.0600
            10  O5a O    18.1300  -15.9600
            11  C8y C    15.7500  -17.3600
            12  C8x C    14.5600  -18.0600
            13  C8y C    13.3000  -17.3600
            14  C8y C    13.3000  -15.9600
            15  C8x C    14.4900  -15.2600
            16  C8y C    15.7500  -15.9600
            17  C8y C    12.1100  -18.0600
            18  C8y C    12.1100  -19.4600
            19  N4y N    10.8500  -20.1600
            20  C8y C     9.6600  -19.4600
            21  C8y C     9.6600  -18.0600
            22  C8x C    10.8500  -17.3600
            23  C8x C     8.4700  -20.1600
            24  C8y C     7.2100  -19.4600
            25  N5x N     7.2100  -18.0600
            26  C8x C     8.4700  -17.3600
            27  N1b N     6.0200  -20.1600
            28  C1a C     4.8300  -19.4600
            29  C1b C    10.8500  -21.5600
            30  C1a C    12.0400  -22.2600
            31  O5x O    13.3000  -20.1600
            32  X   Br   12.1100  -15.2600
            33  X   F    16.9400  -15.2600
BOND        36
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 2
            11    9  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18   13  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   17  22 2
            25   20  23 2
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   21  26 2
            30   24  27 1
            31   27  28 1
            32   19  29 1
            33   29  30 1
            34   18  31 2
            35   14  32 1
            36   16  33 1

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