KEGG   DRUG: Lonapegsomatropin
Entry
D11486                      Drug                                   

Name
Lonapegsomatropin (USAN/INN);
Lonapegsomatropin-tcgd;
Skytrofa (TN)
Product
Sequence
FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV
QCRSVEGSCG F
(Disulfide bridge: 53-165, 182-189)
  Type
Peptide
Class
Other
 DG03170  Growth hormone receptor agonist
Remark
Product: D11486<US>
Efficacy
Growth hormone (GH) receptor agonist
  Disease
Growth hormone deficiency [DS:H00254]
Comment
Treatment of growth hormone deficiency
Target
GHR [HSA:2690] [KO:K05080]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04080  Neuroactive ligand-receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    GHR
     D11486  Lonapegsomatropin (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11486
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11486
Other DBs
CAS: 1934255-39-6
PubChem: 384585462
LinkDB

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