KEGG   DRUG: Tomaralimab
Entry
D11503                      Drug                                   
Name
Tomaralimab (USAN)
Formula
C6452H9958N1706O2028S44
Exact mass
145193.6239
Mol weight
145283.25
Sequence
(Heavy chain)
QVQLVQSGSE LKKPGASVKL SCKASGFTFT TYGINWVRQA PGQGLEWIGW IYPRDGSTNF
NENFKDRATI TVDTSASTAY MELSSLRSED TAVYFCARLT GGTFLDYWGQ GTTVTVSSAS
TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTKTYT CNVDHKPSNT KVDKRVESKY GPPCPPCPAP EFLGGPSVFL
FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV
VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ
VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV
FSCSVMHEAL HNHYTQKSLS LSLGK
(Light chain)
DIVLTQSPAT LSLSPGERAT LSCRASESVE YYGTSLMQWY QQKPGQPPKL LIFGASNVES
GVPDRFSGSG SGTDFTLKIS RVEAEDVGMY FCQQSRKLPW TFGGGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: H22-H96, H132-L218, H145-H201, H224-H'224, H227-'227, H259-H319, H365-H423, H'22-H'96, H'132-L'218, H'145-H'201, H'259-H'319, H'365-H'423, L23-L92, L138-L198, L'23-L'92, L'138-L'198)
  Type
Peptide
Efficacy
Antineoplastic, Anti-Toll-like receptor 2 antibody
  Type
Monoclonal antibody
Comment
Treatment of cancer and myelodysplastic syndrome
Target
TLR2 (CD282) [HSA:7097] [KO:K10159]
  Pathway
hsa04620  Toll-like receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Pattern recognition receptors
   Toll-like receptors
    TLR2 (CD282)
     D11503  Tomaralimab (USAN)
Other DBs
CAS: 1449294-76-1
PubChem: 384585479
LinkDB

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