KEGG   DRUG: Lefamulin
Entry
D11631                      Drug                                   
Name
Lefamulin (USAN/INN)
Formula
C28H45NO5S
Exact mass
507.3018
Mol weight
507.7256
Structure
Class
Antibacterial
 DG01813  Pleuromutilin
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: J01XX12
Chemical structure group: DG03066
Product (DG03066): D11632<US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Pleuromutilin [CPD:C09169] derivative
Target
50S ribosomal subunit
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XX Other antibacterials
     J01XX12 Lefamulin
      D11631  Lefamulin (USAN/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01813  Pleuromutilin
   DG03066  Lefamulin
    D11631  Lefamulin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG03066  Lefamulin
     D11631  Lefamulin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Pleuromutilin
    D11631  Lefamulin (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11631
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11631
Drug groups [BR:br08330]
 Antibacterial
  DG01813  Pleuromutilin
   DG03066  Lefamulin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG03066  Lefamulin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Pleuromutilin
    DG03066  Lefamulin
Other DBs
CAS: 1061337-51-6
PubChem: 405226498
PDB-CCD: 62B[PDBj]
LinkDB
KCF data

ATOM        35
            1   C1z C    25.2000  -16.8700
            2   C1y C    24.2200  -17.8500
            3   C1y C    25.2000  -15.4700
            4   C1x C    26.4600  -17.5000
            5   C1x C    25.2000  -18.3400
            6   C1z C    22.8200  -17.8500
            7   C5x C    24.8500  -19.1100
            8   C1y C    24.2200  -14.4900
            9   C1a C    26.4600  -14.9100
            10  C1x C    26.1800  -18.9000
            11  C1x C    23.8700  -18.2700
            12  C1y C    21.7700  -16.8700
            13  C1y C    22.7500  -19.2500
            14  C1a C    21.9100  -18.9000
            15  O5x O    24.2200  -20.3700
            16  C1z C    22.8200  -14.4900
            17  O1a O    24.7100  -13.1600
            18  C1x C    21.7700  -15.4700
            19  O7a O    20.5100  -17.3600
            20  C1a C    22.4000  -20.5800
            21  C7a C    19.2500  -16.6600
            22  C1b C    18.0600  -17.3600
            23  O6a O    19.2500  -15.2600
            24  S2a S    16.8700  -16.6600
            25  C1y C    15.6800  -17.3600
            26  C2b C    22.2600  -13.1600
            27  C1a C    21.4200  -14.4900
            28  C2a C    22.2600  -11.8300
            29  C1x C    15.6800  -18.7600
            30  C1x C    14.4900  -19.4600
            31  C1y C    13.3000  -18.7600
            32  C1x C    13.3000  -17.3600
            33  C1y C    14.4900  -16.6600
            34  O1a O    14.4900  -15.2600
            35  N1a N    12.1100  -19.4600
BOND        38
            1     3   8 1
            2     3   9 1 #Down
            3     4  10 1
            4     5  11 1
            5     6  12 1
            6     6  13 1
            7     6  14 1 #Down
            8     7  15 2
            9     8  16 1
            10    8  17 1 #Up
            11   12  18 1
            12   12  19 1 #Down
            13   13  20 1 #Up
            14   19  21 1
            15   21  22 1
            16   21  23 2
            17   22  24 1
            18    7  10 1
            19   11  13 1
            20   16  18 1
            21   25  24 1 #Down
            22    1   2 1
            23    1   3 1
            24    1   4 1
            25    1   5 1 #Up
            26    2   6 1
            27    2   7 1
            28   16  26 1 #Up
            29   16  27 1 #Down
            30   26  28 2
            31   25  29 1
            32   29  30 1
            33   30  31 1
            34   31  32 1
            35   32  33 1
            36   25  33 1
            37   33  34 1 #Up
            38   31  35 1 #Up

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