KEGG   DRUG: Mirdametinib
Entry
D11675                      Drug                                   
Name
Mirdametinib (USAN);
Gomekli (TN)
Product
GOMEKLI (SpringWorks Therapeutics)
Formula
C16H14F3IN2O4
Exact mass
481.9950
Mol weight
482.19
Structure
Class
Antineoplastic
 DG03137  MEK inhibitor
Metabolizing enzyme substrate
 DG02970  CES substrate
 DG02924  UGT substrate
  DG03335  UGT1A6 substrate
  DG03190  UGT2B7 substrate
Remark
ATC code: L01EE05
Product: D11675<US>
Efficacy
Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor
  Disease
Neurofibromatosis type 1, with plexiform neurofibromas [DS:H01437]
Target
MAP2K (MEK) [HSA:5604 5605] [KO:K04368 K04369]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa05200  Pathways in cancer
hsa05214  Glioma
  Network
nt06273  Glioma
nt06526  MAPK signaling
Metabolism
Enzyme: UGT1A6 [HSA:54578], UGT2B7 [HSA:7364], CES [HSA:1066 8824 23491 221223]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EE Mitogen-activated protein kinase (MEK) inhibitors
     L01EE05 Mirdametinib
      D11675  Mirdametinib (USAN) <US>
Drug groups [BR:br08330]
 Antineoplastic
  DG03137  MEK inhibitor
   D11675  Mirdametinib
 Metabolizing enzyme substrate
  DG02970  CES substrate
   D11675  Mirdametinib
  DG02924  UGT substrate
   DG03335  UGT1A6 substrate
    D11675  Mirdametinib
   DG03190  UGT2B7 substrate
    D11675  Mirdametinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   STE group
    MAP2K (MEK)
     D11675  Mirdametinib (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11675
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11675
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11675
Other DBs
CAS: 391210-10-9
PubChem: 405226542
PDB-CCD: 4BM[PDBj]
LinkDB
KCF data

ATOM        26
            1   C8y C    10.8214  -20.4819
            2   C8x C    10.8214  -21.8873
            3   C8x C    12.0160  -22.5900
            4   C8y C    13.2808  -21.8873
            5   C8y C    13.2808  -20.4819
            6   C8y C    12.0160  -19.7792
            7   C5a C    14.4754  -22.5900
            8   X   F     9.6268  -19.7792
            9   N1b N    15.6699  -21.8873
            10  O5a O    14.4754  -23.9954
            11  O2a O    16.8645  -22.5900
            12  C1b C    18.0591  -21.8873
            13  C1c C    19.2536  -22.5900
            14  C1b C    20.4482  -21.8873
            15  O1a O    19.2536  -23.9954
            16  O1a O    21.6428  -22.5900
            17  N1b N    14.4890  -19.7710
            18  C8y C    14.4890  -18.3710
            19  C8y C    15.7155  -17.6632
            20  C8x C    15.7158  -16.2632
            21  C8y C    14.5035  -15.5629
            22  C8x C    13.2771  -16.2707
            23  C8x C    13.2768  -17.6707
            24  X   F    12.0696  -18.4106
            25  X   I    14.5041  -14.1401
            26  X   F    16.9429  -18.3727
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     1   8 1
            9     7   9 1
            10    7  10 2
            11    9  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   13  15 1 #Up
            16   14  16 1
            17    5  17 1
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   18  23 1
            25    6  24 1
            26   21  25 1
            27   19  26 1

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