| Entry |
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|---|
| Name |
Gusacitinib (USAN/INN) |
|---|
| Formula |
C24H28N8O2
|
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| Exact mass |
460.2335
|
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| Mol weight |
460.53
|
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| Structure |
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| Class |
Antineoplastic
DG01918 Tyrosine kinase inhibitor
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG02020 JAK inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic |
|---|
| Comment |
Treatment of autoimmune disorders and hematological cancers
|
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| Target |
|
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| Pathway |
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| Interaction |
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| Brite |
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG03080 Gusacitinib
D11676 Gusacitinib
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG02020 JAK inhibitor
DG03080 Gusacitinib
D11676 Gusacitinib
Target-based classification of drugs [BR:br08310]
Protein kinases
Non-receptor tyrosine kinases
SYK family
SYK
D11676 Gusacitinib (USAN/INN)
JAK family
JAK1
D11676 Gusacitinib (USAN/INN)
JAK2
D11676 Gusacitinib (USAN/INN)
JAK3
D11676 Gusacitinib (USAN/INN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG03080 Gusacitinib
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG02020 JAK inhibitor
DG03080 Gusacitinib
|
|---|
| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 34
1 N5x N 7.2800 -16.1000
2 N4x N 7.2800 -17.5000
3 C8y C 8.4700 -18.2000
4 C8y C 9.7300 -17.5000
5 C8y C 9.7300 -16.1000
6 C8x C 8.4700 -15.4000
7 C8y C 10.9200 -18.2000
8 N5x N 12.1100 -17.5000
9 C8y C 12.1100 -16.1000
10 N5x N 10.9200 -15.4000
11 N1y N 13.3000 -15.4000
12 C1x C 14.4900 -16.1000
13 C1x C 15.7500 -15.4000
14 C1y C 15.7500 -14.0000
15 C1x C 14.5600 -13.3000
16 C1x C 13.3000 -14.0000
17 C1b C 16.9400 -13.3000
18 C3b C 18.1300 -14.0000
19 N3a N 19.3900 -14.7000
20 N1b N 10.9200 -19.6000
21 C8y C 12.1100 -20.3000
22 C8x C 12.1100 -21.7000
23 C8x C 13.3700 -22.4000
24 C8y C 14.5600 -21.7000
25 C8x C 14.5600 -20.3000
26 C8x C 13.3700 -19.6000
27 N1y N 15.7500 -22.4000
28 C1x C 15.7500 -23.8000
29 C1x C 17.0100 -24.5000
30 C1y C 18.2000 -23.8000
31 C1x C 18.2000 -22.4000
32 C1x C 17.0100 -21.7000
33 O1a O 19.3900 -24.5000
34 O5x O 8.4700 -19.6000
BOND 38
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 2
8 7 8 1
9 8 9 2
10 9 10 1
11 5 10 2
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 11 16 1
19 14 17 1
20 17 18 1
21 18 19 3
22 7 20 1
23 20 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 21 26 1
30 24 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 30 31 1
35 31 32 1
36 27 32 1
37 30 33 1
38 3 34 2
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