| Entry |
|
|---|
| Name |
Asenapine (INN);
Secuado (TN) |
|---|
| Product |
|
|---|
| Formula |
C17H16ClNO
|
|---|
| Exact mass |
285.0920
|
|---|
| Mol weight |
285.77
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
| Product (DG03100): | D11769<US> D02995<JP/US> |
|
|---|
| Efficacy |
Antipsychotic |
|---|
| Disease |
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AH Diazepines, oxazepines, thiazepines and oxepines
N05AH05 Asenapine
D11769 Asenapine (INN) <US>
USP drug classification [BR:br08302]
Antipsychotics
2nd Generation/Atypical
Asenapine
D11769 Asenapine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03100 Asenapine
D11769 Asenapine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG03100 Asenapine
D11769 Asenapine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG03100 Asenapine
D11769 Asenapine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D11769 Asenapine (INN) <US>
Serotonin
HTR2A
D11769 Asenapine (INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11769
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03100 Asenapine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG03100 Asenapine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG03100 Asenapine
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 20
1 C8y C 17.7185 -15.0536
2 C1y C 18.6245 -16.0989
3 C1y C 20.0183 -16.0989
4 C8y C 20.8546 -14.9839
5 C8y C 17.9973 -13.6597
6 C8y C 20.5061 -13.6597
7 O2x O 19.2517 -13.0325
8 C8x C 21.5515 -12.6841
9 C8x C 22.8756 -13.0325
10 C8x C 23.2241 -14.4263
11 C8x C 22.1787 -15.4020
12 C8x C 16.3944 -15.4717
13 C8y C 15.3490 -14.5657
14 C8x C 15.6278 -13.1719
15 C8x C 16.9519 -12.7538
16 C1x C 20.5061 -17.4231
17 N1y N 19.3911 -18.2594
18 C1x C 18.2063 -17.4231
19 X Cl 14.0249 -14.9839
20 C1a C 19.3911 -19.6532
BOND 23
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 6 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 4 11 2
13 1 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 5 15 2
18 3 16 1
19 16 17 1
20 17 18 1
21 2 18 1
22 13 19 1
23 17 20 1
|
|---|
