| Entry |
|
|---|
| Name |
Tesevatinib tosylate (USAN) |
|---|
| Formula |
C24H25Cl2FN4O2. C7H8O3S
|
|---|
| Exact mass |
662.1533
|
|---|
| Mol weight |
663.59
|
|---|
| Structure |
|
|---|
| Class |
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antineoplastic, Receptor tyrosine kinase inhibitor |
|---|
| Comment |
Treatment of cancer and polycystic kidney disease
|
|---|
| Target |
|
|---|
| Pathway |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance |
|
|---|
| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03101 Tesevatinib
D11773 Tesevatinib tosylate
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
EGFR family
EGFR
D11773 Tesevatinib tosylate (USAN)
ERBB2 (HER2, CD340)
D11773 Tesevatinib tosylate (USAN)
VEGFR family
VEGFR2 (KDR)
D11773 Tesevatinib tosylate (USAN)
VEGFR3 (FLT4)
D11773 Tesevatinib tosylate (USAN)
EPH family
EPHB4
D11773 Tesevatinib tosylate (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG01917 Receptor tyrosine kinase inhibitor
DG03101 Tesevatinib
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 44
1 N1b N 13.1819 -17.5992
2 C8y C 14.3739 -18.3004
3 C8y C 14.3739 -19.7027
4 C8y C 15.6360 -20.4039
5 C8y C 16.8279 -19.7027
6 C8x C 16.8279 -18.3004
7 C8x C 15.6360 -17.5992
8 X Cl 15.6360 -21.8062
9 X F 13.1819 -20.4039
10 X Cl 18.0199 -20.4039
11 C8y C 13.1819 -16.1969
12 C8y C 14.3739 -14.0934
13 C8y C 14.3739 -15.4957
14 N5x N 11.9198 -15.4957
15 C8x C 11.9198 -14.0934
16 N5x N 13.1819 -13.3922
17 C8x C 15.5659 -13.3922
18 C8y C 16.8279 -14.0934
19 C8y C 16.8279 -15.4957
20 C8x C 15.5659 -16.1969
21 O2a O 18.0199 -13.3922
22 C1b C 19.1418 -14.0934
23 O2a O 18.0199 -16.1969
24 C1a C 19.1418 -15.4957
25 C1y C 20.3338 -13.3922
26 C1x C 21.5809 -13.9352
27 C1y C 22.4826 -12.9169
28 C1y C 21.7928 -11.7446
29 C1x C 20.4648 -12.0384
30 C1x C 23.8106 -12.6231
31 N1y N 23.9416 -11.2693
32 C1x C 22.6945 -10.7264
33 C1a C 25.1467 -10.5602
34 C8x C 24.0800 -18.4100
35 C8x C 24.0800 -19.8100
36 C8y C 25.2924 -20.5100
37 C8x C 26.5049 -19.8100
38 C8x C 26.5049 -18.4100
39 C8y C 25.2924 -17.7100
40 S4a S 25.2924 -16.3102
41 O1d O 23.8924 -16.3102
42 O1d O 26.6924 -16.3102
43 O1d O 25.2924 -14.9102
44 C1a C 25.2924 -21.9100
BOND 48
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 6 7 2
7 2 7 1
8 4 8 1
9 3 9 1
10 5 10 1
11 1 11 1
12 12 13 2
13 13 11 1
14 11 14 2
15 14 15 1
16 15 16 2
17 12 16 1
18 12 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 13 20 1
23 18 21 1
24 21 22 1
25 19 23 1
26 23 24 1
27 25 22 1 #Up
28 25 26 1
29 26 27 1
30 27 28 1
31 28 29 1
32 25 29 1
33 27 30 1
34 30 31 1
35 31 32 1
36 28 32 1
37 31 33 1
38 34 35 2
39 35 36 1
40 36 37 2
41 37 38 1
42 38 39 2
43 34 39 1
44 39 40 1
45 40 41 2
46 40 42 2
47 40 43 1
48 36 44 1
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|---|
