KEGG   DRUG: Tilavonemab
Entry
D11840                      Drug                                   
Name
Tilavonemab (USAN/INN)
Formula
C6480H9956N1720O2028S42
Exact mass
145659.7071
Mol weight
145749.50
Sequence
(Heavy chain)
EVKVVESGGG LVQPGGSMKL SCVVSGFTFS NYWVNWVRQA PGKGLEWVAQ IRLKSDNYAT
HYEESVKGRF TISRDDSKSS VYLQMNNLRA EDSGIYYCTN WEDYWGQGTT VTVSSASTKG
PSVFPLAPCS RSTSESTAAL GCLVKDYFPE PVTVSWNSGA LTSGVHTFPA VLQSSGLYSL
SSVVTVPSSS LGTKTYTCNV DHKPSNTKVD KRVESKYGPP CPPCPAPEFL GGPSVFLFPP
KPKDTLMISR TPEVTCVVVD VSQEDPEVQF NWYVDGVEVH NAKTKPREEQ FNSTYRVVSV
LTVLHQDWLN GKEYKCKVSN KGLPSSIEKT ISKAKGQPRE PQVYTLPPSQ EEMTKNQVSL
TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSRLTVDKS RWQEGNVFSC
SVMHEALHNH YTQKSLSLSL GK
(Light chain)
DIVLTQSPDS LAVSLGERAT ISCRASQSVS TSRYSYIHWY QQKPGQPPKL LIKYASNLES
GVPSRFSGSG SGTDFTLNIH PLEPEDFATY YCHHSWEIPL TFGQGTKLEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: H22-H98, H129-L218, H142-H198, H221-H'221, H224-H'224, H256-H316, H362-H420, H'22-H'98, H'129-L'218, H'142-H'198, H'256-H'316, H'362-H'420, L23-L92, L138-L198, L'23-L'92, L'138-L'198)
  Type
Peptide
Efficacy
Dementia therapeutic agent, Anti-tau protein antibody
  Type
Monoclonal antibody
Comment
Treatment of Alzheimer's disease, supranuclear palsy and neurodegenerative disorders
Target
MAPT (TAU) [HSA:4137] [KO:K04380]
  Pathway
hsa04010  MAPK signaling pathway
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    MAPT (TAU)
     D11840  Tilavonemab (USAN/INN)
Other DBs
CAS: 2096513-89-0
PubChem: 433774515
LinkDB

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