KEGG   Homo sapiens (human): 4137
Entry
4137              CDS       T01001                                 
Symbol
MAPT, DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, Tau-PHF6, tau-40
Name
(RefSeq) microtubule associated protein tau
  KO
K04380  microtubule-associated protein tau
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06541  Cytoskeleton in neurons
  Element
N00997  Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
N01835  SEMA3-CRMP2/MAPT axon guidance signaling
N01858  EFNB1-MAPT axon guidance signaling
Disease
H00057  Parkinson disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00077  Progressive supranuclear palsy
H00078  Frontotemporal lobar degeneration
Drug target
Bepranemab: D12228
Etalanetug: D12848
Flortaucipir (18F): D11210<JP/US>
Gosuranemab: D11293
Hydromethylthionine (DG03014): D11384 D11427
Posdinemab: D12636
Semorinemab: D11687
Tilavonemab: D11840
Zagotenemab: D11533
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4137 (MAPT)
   05012 Parkinson disease
    4137 (MAPT)
   05022 Pathways of neurodegeneration - multiple diseases
    4137 (MAPT)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    4137 (MAPT)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4137 (MAPT)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4137 (MAPT)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     4137 (MAPT)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    4137 (MAPT)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     4137 (MAPT)
SSDB
Motif
Pfam: Tubulin-binding Tmemb_cc2
Other DBs
NCBI-GeneID: 4137
NCBI-ProteinID: NP_058519
OMIM: 157140
HGNC: 6893
Ensembl: ENSG00000186868
UniProt: P10636
Structure
LinkDB
Position
17:45894554..46028334
AA seq 758 aa
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
NT seq 2277 nt   +upstreamnt  +downstreamnt
atggctgagccccgccaggagttcgaagtgatggaagatcacgctgggacgtacgggttg
ggggacaggaaagatcaggggggctacaccatgcaccaagaccaagagggtgacacggac
gctggcctgaaagaatctcccctgcagacccccactgaggacggatctgaggaaccgggc
tctgaaacctctgatgctaagagcactccaacagcggaagatgtgacagcacccttagtg
gatgagggagctcccggcaagcaggctgccgcgcagccccacacggagatcccagaagga
accacagctgaagaagcaggcattggagacacccccagcctggaagacgaagctgctggt
cacgtgacccaagagcctgaaagtggtaaggtggtccaggaaggcttcctccgagagcca
ggccccccaggtctgagccaccagctcatgtccggcatgcctggggctcccctcctgcct
gagggccccagagaggccacacgccaaccttcggggacaggacctgaggacacagagggc
ggccgccacgcccctgagctgctcaagcaccagcttctaggagacctgcaccaggagggg
ccgccgctgaagggggcagggggcaaagagaggccggggagcaaggaggaggtggatgaa
gaccgcgacgtcgatgagtcctccccccaagactcccctccctccaaggcctccccagcc
caagatgggcggcctccccagacagccgccagagaagccaccagcatcccaggcttccca
gcggagggtgccatccccctccctgtggatttcctctccaaagtttccacagagatccca
gcctcagagcccgacgggcccagtgtagggcgggccaaagggcaggatgcccccctggag
ttcacgtttcacgtggaaatcacacccaacgtgcagaaggagcaggcgcactcggaggag
catttgggaagggctgcatttccaggggcccctggagaggggccagaggcccggggcccc
tctttgggagaggacacaaaagaggctgaccttccagagccctctgaaaagcagcctgct
gctgctccgcgggggaagcccgtcagccgggtccctcaactcaaagctcgcatggtcagt
aaaagcaaagacgggactggaagcgatgacaaaaaagccaagacatccacacgttcctct
gctaaaaccttgaaaaataggccttgccttagccccaaacaccccactcctggtagctca
gaccctctgatccaaccctccagccctgctgtgtgcccagagccaccttcctctcctaaa
tacgtctcttctgtcacttcccgaactggcagttctggagcaaaggagatgaaactcaag
ggggctgatggtaaaacgaagatcgccacaccgcggggagcagcccctccaggccagaag
ggccaggccaacgccaccaggattccagcaaaaaccccgcccgctccaaagacaccaccc
agctctggtgaacctccaaaatcaggggatcgcagcggctacagcagccccggctcccca
ggcactcccggcagccgctcccgcaccccgtcccttccaaccccacccacccgggagccc
aagaaggtggcagtggtccgtactccacccaagtcgccgtcttccgccaagagccgcctg
cagacagcccccgtgcccatgccagacctgaagaatgtcaagtccaagatcggctccact
gagaacctgaagcaccagccgggaggcgggaaggtgcagataattaataagaagctggat
cttagcaacgtccagtccaagtgtggctcaaaggataatatcaaacacgtcccgggaggc
ggcagtgtgcaaatagtctacaaaccagttgacctgagcaaggtgacctccaagtgtggc
tcattaggcaacatccatcataaaccaggaggtggccaggtggaagtaaaatctgagaag
cttgacttcaaggacagagtccagtcgaagattgggtccctggacaatatcacccacgtc
cctggcggaggaaataaaaagattgaaacccacaagctgaccttccgcgagaacgccaaa
gccaagacagaccacggggcggagatcgtgtacaagtcgccagtggtgtctggggacacg
tctccacggcatctcagcaatgtctcctccaccggcagcatcgacatggtagactcgccc
cagctcgccacgctagctgacgaggtgtctgcctccctggccaagcagggtttgtga

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