KEGG ORTHOLOGY: K04380

ORTHOLOGY: K04380

Entry

K04380                      KO

Symbol

MAPT, TAU

Name

microtubule-associated protein tau

Pathway

map04010

MAPK signaling pathway

map05010

Alzheimer disease

map05012

Parkinson disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00057

Parkinson disease

H00058

Amyotrophic lateral sclerosis (ALS)

H00077

Progressive supranuclear palsy

H00078

Frontotemporal lobar degeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04380  MAPT, TAU; microtubule-associated protein tau
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04380  MAPT, TAU; microtubule-associated protein tau
   05012 Parkinson disease
    K04380  MAPT, TAU; microtubule-associated protein tau
   05022 Pathways of neurodegeneration - multiple diseases
    K04380  MAPT, TAU; microtubule-associated protein tau
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K04380  MAPT, TAU; microtubule-associated protein tau
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04380  MAPT, TAU; microtubule-associated protein tau
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K04380  MAPT, TAU; microtubule-associated protein tau
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04380  MAPT, TAU; microtubule-associated protein tau
Membrane trafficking [BR:ko04131]
Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    K04380  MAPT, TAU; microtubule-associated protein tau
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     K04380  MAPT, TAU; microtubule-associated protein tau

Genes

HSA:	4137(MAPT)

PTR:	450177(MAPT)

PPS:	100987023(MAPT)

GGO:	101142624(MAPT)

PON:	100432958(MAPT)

PPYG:

129017902(MAPT)

NLE:	100601409(MAPT)

HMH:	116475002(MAPT)

SSYN:

129470170(MAPT)

MCC:	574327(MAPT) 712421

MCF:	102119414(MAPT)

MTHB:

126938919 126953300

MNI:	105468425(MAPT) 105479529

CSAB:

103243264(MAPT)

CATY:

105585777(MAPT) 105589886

PANU:

101004302(MAPT) 101018182

TGE:	112609254(MAPT)

MLEU:

105555143(MAPT) 105555243

RRO:	104682393(MAPT)

RBB:	108529371(MAPT)

TFN:	117087581(MAPT)

PTEH:

111529278(MAPT)

CANG:

105508648 105520290(MAPT)

CJC:	100403309(MAPT)

SBQ:	101029753(MAPT)

CIMI:

108318302(MAPT)

ANAN:

105711196(MAPT)

CSYR:

103251594

MMUR:

105863664(MAPT)

LCAT:

123620566(MAPT)

ERUF:

138392184(MAPT)

PCOQ:

105819080(MAPT)

OGA:	100951532(MAPT)

MMU:	17762(Mapt)

MCAL:

110304807(Mapt)

MPAH:

110331493(Mapt)

RNO:	29477(Mapt)

MCOC:

116076902(Mapt)

ANU:	117710422(Mapt)

ASYL:

127695236(Mapt)

MUN:	110545637(Mapt)

CGE:

100765120

MAUA:

101828445(Mapt)

PROB:

127217676(Mapt)

PLEU:

114702276(Mapt)

MORG:

121435969(Mapt)

MFOT:

126487542

AAMP:

119812136(Mapt)

NGI:	103724766(Mapt)

HGL:	101719489(Mapt)

CPOC:

100735442(Mapt)

CCAN:

109684813(Mapt)

DORD:

105998555(Mapt)

DSP:	122103501(Mapt)

DMER:

138830850(Mapt)

PLOP:

125366515(Mapt)

NCAR:

124980973

MMMA:

107160525(Mapt)

ITI:	101962404(Mapt)

OCU:

100344003

OPI:	101520785(MAPT)

OCZ:	121162331(MAPT)

TUP:	102487338(MAPT)

GVR:	103598652(MAPT)

CFA:	480488(MAPT)

CLUD:

112653038(MAPT)

VVP:	112920687(MAPT)

VLG:	121472963(MAPT)

NPO:	129507366(MAPT)

AML:	100476507(MAPT)

UMR:	121104977(MAPT)

UAH:	113265313(MAPT)

UAR:	123803222(MAPT)

ELK:

111158157

LLV:

125086936

MPUF:

101679947(MAPT)

MNP:	132003666(MAPT)

MLK:	131815906(MAPT)

NVS:	122906106(MAPT)

ORO:	101371518(MAPT)

EJU:	114196731(MAPT)

ZCA:	113939784(MAPT)

MLX:	118027177(MAPT)

MANO:

123853899(MAPT)

NSU:	110570453(MAPT)

LWW:	102736771(MAPT)

FCA:	101089557(MAPT)

PYU:	121020155(MAPT)

PCOO:

112862026(MAPT)

PBG:	122485735(MAPT)

PVIV:

125151859(MAPT)

LRUF:

124513561

LGF:	123603878(MAPT)

AJU:

106988843

PTG:	102967519(MAPT)

PPAD:

109259745(MAPT)

PUC:

125927337

PLEZ:

122206734(MAPT)

HHV:	120244270(MAPT)

CCRU:

144245005(MAPT)

BTA:	281296(MAPT)

BOM:	102270620(MAPT)

BIU:	109573661(MAPT)

BBUB:

102415365(MAPT)

BBIS:

104982950(MAPT)

CHX:	100860820(MAPT)

OAS:	101121024(MAPT)

BTAX:

128064960(MAPT)

CSUM:

138083113(MAPT)

ODA:	120866971(MAPT)

CCAD:

122440039(MAPT)

MREE:

136149212(MAPT)

OVR:	110129709(MAPT)

MBEZ:

129544523(MAPT)

SSC:	100738351(MAPT)

CFR:	102508974(MAPT)

CBAI:

105071480(MAPT)

CDK:	105090432(MAPT)

VPC:	102528315(MAPT)

BACU:

103009499(MAPT)

BMUS:

118886713(MAPT)

LVE:	103090402(MAPT)

OOR:	101276955(MAPT)

LALB:

132511585(MAPT)

GMF:

115849115

DDP:	132415184(MAPT)

DLE:	111182584(MAPT)

PCAD:

102996376(MAPT)

PSIU:

116744941(MAPT)

PPHC:

136139025(MAPT)

NASI:

112410117(MAPT)

ECB:	100054638(MAPT)

EPZ:	103552915(MAPT)

EAI:	106836496(MAPT)

MYB:	102260052(MAPT)

MYD:	102757836(MAPT)

MMYO:

118671627(MAPT)

MLF:	102424304(MAPT)

MDT:	132218542(MAPT)

MYUM:

138994739(MAPT)

PKL:	118726361(MAPT)

EFUS:

103293163(MAPT)

MNA:	107530997(MAPT)

DRO:	112316173(MAPT)

SHON:

119003781(MAPT)

AJM:	119062588(MAPT)

PDIC:

114503143(MAPT)

PHAS:

123816832(MAPT)

MMF:	118634096(MAPT)

PPAM:

129071577(MAPT)

HAI:	109380299(MAPT)

RFQ:	117012835(MAPT)

PALE:

102878980(MAPT)

PGIG:

120589267(MAPT)

PVP:	105303449(MAPT)

RAY:	107508176(MAPT)

MJV:	108398647(MAPT)

TOD:	119232082(MAPT)

SARA:

101559083(MAPT)

SFUM:

130035870(MAPT)

SETR:

126020348(MAPT)

LAV:	100663624(MAPT)

TMU:

101360746

ETF:	101649733(MAPT)

DNM:	101419371(MAPT)

MDO:	100025077(MAPT) 100620008

GAS:	123247918(MAPT)

SHR:	100920214(MAPT)

AFZ:

127560384

PCW:	110215713(MAPT)

TVP:	118846107(MAPT)

PBRV:

138152436(MAPT)

OAA:	100088033(MAPT)

TACU:

119934935(MAPT)

GGA:	426737(MAPT)

PCOC:

116233797(MAPT)

MGP:

100545041

CJO:	107325179(MAPT)

TPAI:

128088784(MAPT)

LMUT:

125684645(MAPT)

NMEL:

110388458(MAPT)

APLA:

101803342(MAPT)

AACU:

137844662(MAPT)

ACYG:

106045980(MAPT)

CATA:

118261227

AFUL:

116498375(MAPT)

TGU:	100225617(MAPT)

LSR:	110474819(MAPT)

SCAN:

103821801(MAPT)

PMOA:

120498170(MAPT)

OTC:	121347686(MAPT)

PRUF:

121352427(MAPT)

ATRC:

139601802(MAPT)

GFR:

102033466

FAB:	101818271(MAPT)

OMA:	130264028(MAPT)

PHI:	102103099(MAPT)

PMAJ:

107215247(MAPT)

CCAE:

111940054(MAPT)

CCW:

104698638

CBRC:

103619888(MAPT)

ACOE:

138099190(MAPT)

ETL:	114071148(MAPT)

ZAB:	102062388(MAPT)

ZLE:	135458369(MAPT)

SVG:

106861189

MMEA:

130586240(MAPT)

HRT:	120763684(MAPT)

SATI:

136372310(MAPT)

CCIC:

134053249

FPG:	101924165(MAPT)

FCH:	102046942(MAPT)

NNT:	104402756(MAPT)

SHAB:

115617782(MAPT)

ACUN:

113489247(MAPT)

TALA:

104359825(MAPT)

ACHC:

115344344(MAPT)

HALD:

104322734

HLE:	104827993(MAPT)

AGEN:

126038720

HHAR:

128140815(MAPT)

BBUT:

142034662(MAPT)

GCL:

CSTI:

LDI:

MNB:

DPUB:

104309233(MAPT)

PPUS:

135191931(MAPT)

BRHI:

104500059

EGZ:	104127025(MAPT)

NNI:	104012255(MAPT)

PCRI:

104028387

PCAO:

104042733(MAPT)

PARX:

142068020(MAPT)

PADL:

103913879(MAPT)

AFOR:

103906074(MAPT)

FGA:

104082032

CBOR:

142091863(MAPT)

GSTE:

104258644

CBOY:

140662291

MAME:

142419640(MAPT)

CLV:	102098028(MAPT)

CNIC:

135998041(MAPT)

MUI:	104542865(MAPT)

PGUU:

104465736

PLET:

104616562(MAPT)

CMAC:

104477375

TEO:

104372986

BREG:

104634666

OHA:	104338719(MAPT)

ACAR:

104529948

CPEA:

104397946(MAPT)

CVF:	104285390(MAPT)

RTD:	128919183(MAPT)

CRID:

134524613(MAPT)

LMIC:

141732595(MAPT)

AAM:	106497424(MAPT)

AROW:

112962761(MAPT)

NPD:	112960247(MAPT)

TGT:	104568298(MAPT)

DNE:	112982776(MAPT)

SCAM:

104148951(MAPT)

ASN:	102385004(MAPT)

AMJ:	102570040(MAPT)

CPOO:

109318950(MAPT)

GGN:	109302104(MAPT)

PSS:	102450787(MAPT)

CIZ:	142002590(MAPT)

CMY:	102932440(MAPT)

CCAY:

125626746

LKP:	140903744(MAPT)

NDS:	141978457(MAPT)

DCC:	119849155(MAPT)

CPIC:

101932261(MAPT)

TST:	117869222(MAPT)

CABI:

116831498(MAPT)

MRV:	120392018(MAPT)

ACS:	100563934(mapt)

ASAO:

132778298(MAPT)

PVT:

110082048

SUND:

121933530(MAPT)

PBI:	103060127(MAPT)

PMUR:

107303054(MAPT)

CTIG:

120315157(MAPT)

TSR:	106545992(MAPT)

PGUT:

117664691(MAPT)

APRI:

131197420

PTEX:

113447380(MAPT)

NSS:	113420030(MAPT)

VKO:	123031722(MAPT)

PMUA:

114582250(MAPT)

PRAF:

128399828(MAPT)

ZVI:	118094470(MAPT)

HCG:

128330410

GJA:

107109638

STOW:

125444476(MAPT)

EMC:	129338852(MAPT)

XLA:	100158413(mapt.S) 398307(mapt.L)

XTR:	779920(mapt)

NPR:

RTEM:

ACAT:

PADS:

BBUF:

BGAR:

122941868(MAPT)

DTC:	141096028(MAPT)

PWL:	138299617(MAPT)

MUO:	115481554(MAPT)

GSH:

117347137

DRE:	100000342(mapta) 567833(maptb)

SRX:	107708885 107708886 107732173 107740646 107754302

SANH:

107654024 107662408 107664605 107694967

SGH:	107557372 107582916 107585060 107598589

CCAR:

109047536 109054917 109068702(mapta) 109087789

CAUA:

113046791 113048151 113056385 113111979

CGIB:

127946826 127969435 128025038

PTET:

122355403(mapta)

LROH:

127173839(mapta)

GRF:	141298004(mapta)

OMC:	131537145(maptb) 131551462(mapta)

PPRM:

120469697 120470077(mapta) 120489450(maptb)

RKG:	130070268(maptb) 130080577(mapta)

MAMB:

125255272(mapta) 125272541(maptb)

CIDE:

127523233

CERY:

137008066(mapta) 137010704(maptb)

MASI:

127423345 127427397

TROS:

130561332(maptb)

TDW:	130425652(maptb)

MANU:

129436385(maptb)

PDAB:

135768522(maptb)

IPU:	108272803(maptb) 108274153(mapta)

IFU:	128615966(maptb) 128616954(mapta)

PHYP:

113527224(mapt) 113543880

SMEO:

124382120(maptb) 124388731(mapta)

TFD:	113653574(mapta) 113662794(maptb)

TVC:	132841567(mapta) 132842671(maptb)

CGAR:

128516177(maptb) 128541261(mapta)

NGRA:

132870706(maptb) 132898030(mapta)

TRN:	134309223(maptb) 134321094(mapta)

AMEX:

103023138(maptb) 103047794(mapta)

CMAO:

118809739(mapta)

EEE:	113567934 113587836

SPIL:

134069902(mapta) 134076508(maptb)

TRU:	101068735(mapt)

TFS:

130524881

TNG:	GSTEN00022291G001

LCO:	104937339 104938136

NCC:	104957078(mapt)

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

134870305(mapta)

ELY:	117247124(mapta) 117267741(maptb)

EFO:	125880390(mapta)

PLEP:

121939046 121958441

SLUC:

116035210(maptb) 116060939

ECRA:

117936513(mapta)

PFLV:

114548251 114570265

GAT:	120819595 120828070

PPUG:

119213118 119220025(maptb)

AFB:	129091014(mapta) 129098733(maptb)

CLUM:

117748372

PSWI:

130203224

CANA:

137789358(mapta)

CVE:	137884116(maptb) 137891925(mapta)

MSAM:

119896120(maptb) 119916108(mapta)

SCHU:

122868209(mapta) 122868961(maptb)

EARM:

139300213(maptb) 139303758

CUD:	121527993(mapta) 121529517(maptb)

SPUL:

138594034(mapta) 138604251(maptb)

LMIX:

132953929(maptb) 132955149(mapta)

HTC:	141785364 141809025(maptb)

ALAT:

119009815(mapta) 119014804(maptb)

ASTR:

137588845

PKLU:

139216253(maptb) 139219790(mapta)

MZE:	101463783 101481951

ONL:	100696807 100703600

OAU:	116319400(maptb) 116321248(mapta)

OLA:

101160113

OML:

112154425

CSAI:

133419057 133421777

XMA:	102221832 102225585

XCO:	114152030 114160370

XHE:	116727097 116735417

PRET:

103469030 103481618

PFOR:

103146918 103151103

PLAI:

106938890(mapt) 106951155

PMEI:

106904874(mapt) 106905942

GAF:	122821690(maptb) 122822858

PPRL:

129368236 129373705(maptb)

CVG:	107089302 107090931

CTUL:

119781687(maptb) 119799070(mapta)

GMU:	124862214 124863694 124874943

NFU:	107387288 107395846

KMR:	108243197(maptb) 108251042(mapta)

ALIM:

106521996 106528105

NWH:	119421283(maptb) 119424197(mapta)

AOCE:

111568173(maptb)

EJA:	138204652(mapta)

BFRE:

138624369(mapta) 138631382(maptb)

MCEP:

125022336(mapta)

CSEM:

103381620

POV:

109647001

SSEN:

122759160(mapta) 122785389

SSOE:

131448720(mapta) 131475779

HHIP:

117753462

HSP:	118100853(mapta)

PPLT:

128427218

SMAU:

118287804(mapta) 118288894(maptb) 118304077

LCF:	108873236(maptb) 108891987(mapta)

SDU:	111219558 111239803

SLAL:

111655403 111657526

XGL:	120794020(mapta) 120798058 120805121(maptb)

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140369490(mapta)

MALB:

109962772 109972672

BSPL:

114845804

SJO:	128381690(mapta)

SSCO:

134003311(mapta)

GMH:

115530788

SASA:

100306810(tau) 106600872 106607459

STRU:

115161468 115170943 115196447

OTW:	112223803(mapta) 112225897 112258500(maptb)

OMY:	110486138 110491712(mapta) 110538036(maptb)

OGO:	124048449(mapta)

ONE:	115104029 115106668 115110131

OKI:	109865548 109893211 109898297

OKE:	118365168 118365200(mapta) 118384392

OMM:	135504805(mapta) 135553942 135555843

OCLA:

139364575 139368237 139421068

SALP:

111977801 111980522 112067727

SNH:	120033944 120034665 120045543(mapta)

SFON:

129822697 129832873 129855036(mapta)

CCLU:

121551981 121562058 121569715

ELS:	105006079(mapt) 105023364

OEP:	134015880(maptb) 134031510(mapta)

SFM:	108924753 108941580

PKI:	111856785(mapt)

AANG:

118216497(maptb) 118221282(mapta)

AROT:

135244104(maptb) 135247851(mapta)

CCOG:

133114902(maptb) 133121855(mapta)

LOC:

102694964

PSPA:

121301706 121324221

ARUT:

117433252 117434430(maptb)

PSEX:

120517780(maptb)

LCM:

102357089

CPUN:

140465927

HOC:	132831029(maptb)

SCAU:

119954049(maptb)

LERI:

129710248(maptb)

HAKA:

140741084

PMRN:

116938541 116954723

LRJ:	133346103 133358372 133358375

CIN:

SCLV:

CLEP:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

PFLL:

DME:	Dmel_CG45110(tau)

DER:

6554507

DSI:	Dsimw501_GD18068(Dsim_GD18068)

DYA:	Dyak_GE10550

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10747

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:	108362398 108365615

AOQ:

129252887

ALUD:

128854779

TDA:

119679042

MDE:	101897808 131806994

SCAC:

106095785

LCQ:

111681975

LSQ:

119603297

CVJ:	135963852(tau)

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AMRS:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ013260

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

TCA:

TMOL:

DPA:

ESIM:

136414244(tau)

EFOR:

136346726(tau)

SOY:

RFG:

AGRG:

CSET:

HAXR:

AGB:

LDC:	111505374 111517993

DVV:

NVL:

APLN:

PPYR:

OTU:

BMAN:

MSEX:

DPL:	KGM_211575

BANY:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:	110379486(tau)

HZE:

TNL:

SLIU:

OFU:

ATRA:

CFEL:

API:

DNX:

AGS:

RMD:

DCI:

CLEC:

PHU:	Phum_PHUM267470

BROR:

134533332

FCD:

110842710

DPX:	DAPPUDRAFT_230458

DMK:

DPZ:

AFRA:

PPOI:

VDE:

VJA:

GOE:

CSCU:

PTEP:

HRO:	HELRODRAFT_102146

LGI:	LOTGIDRAFT_163029 LOTGIDRAFT_217179

PVUL:

PCAN:

LSAX:

BARL:

GAE:

HRF:

HRJ:	124287689 124287691

CRG:

MYI:

PMAX:

MMER:

OBI:

SMM:	Smp_162230

LLON:

135497793

» show all

Reference

PMID:3131773

Authors

Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A

Title

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

Journal

Proc Natl Acad Sci U S A 85:4051-5 (1988)
DOI:10.1073/pnas.85.11.4051

Sequence

[hsa:4137]

Reference

PMID:21985311

Authors

Yoshida H, Goedert M

Title

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.

Journal

J Neurochem 120:165-76 (2012)
DOI:10.1111/j.1471-4159.2011.07523.x

Sequence

[hsa:4137]

LinkDB

DBGET integrated database retrieval system