KEGG   DRUG: Acoramidis hydrochloride
Entry
D11973                      Drug                                   
Name
Acoramidis hydrochloride (JAN/USAN);
Attruby (TN);
Beyonttra (TN)
Product
ATTRUBY (BridgeBio Pharma)
Formula
C15H17FN2O3. HCl
Exact mass
328.0990
Mol weight
328.76
Structure
Class
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03183  UGT1A1 substrate
  DG03188  UGT1A9 substrate
  DG03190  UGT2B7 substrate
Remark
Therapeutic category: 2190
ATC code: C01EB25
Chemical structure group: DG03143
Product (DG03143): D11973<JP/US>
Efficacy
Amyloidogenesis suppressant
  Disease
Cardiomyopathy of transthyretin-mediated amyloidosis [DS:H00845]
Comment
Treatment of patients with transthyretin amyloidosis
Target
TTR [HSA:7276] [KO:K20731]
  Pathway
hsa04918  Thyroid hormone synthesis
Metabolism
Enzyme: UGT1A9 [HSA:54600], UGT1A1 [HSA:54658], UGT2B7 [HSA:7364]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB25 Acoramidis
      D11973  Acoramidis hydrochloride (JAN/USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D11973  Acoramidis hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03183  UGT1A1 substrate
    DG03143  Acoramidis
     D11973  Acoramidis hydrochloride
   DG03188  UGT1A9 substrate
    DG03143  Acoramidis
     D11973  Acoramidis hydrochloride
   DG03190  UGT2B7 substrate
    DG03143  Acoramidis
     D11973  Acoramidis hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Other transporters
   Others
    TTR
     D11973  Acoramidis hydrochloride (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11973
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11973
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11973
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11973
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11973
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03183  UGT1A1 substrate
    DG03143  Acoramidis
   DG03188  UGT1A9 substrate
    DG03143  Acoramidis
   DG03190  UGT2B7 substrate
    DG03143  Acoramidis
Other DBs
CAS: 2242751-53-5
PubChem: 497620386
LinkDB
KCF data

ATOM        22
            1   C8y C    20.1993  -16.5521
            2   C8y C    20.1993  -17.9548
            3   C8x C    21.4618  -18.6562
            4   C8x C    22.6541  -17.9548
            5   C8y C    22.6541  -16.5521
            6   C8x C    21.4618  -15.8508
            7   C6a C    23.9165  -15.8508
            8   O6a O    25.1088  -16.5521
            9   O6a O    23.9165  -14.4480
            10  X   F    19.0070  -18.6562
            11  O2a O    19.0070  -15.8508
            12  C1b C    17.8147  -16.5521
            13  C1b C    16.6224  -15.8508
            14  C1b C    15.4301  -16.5521
            15  C8y C    14.2378  -15.8508
            16  C8y C    14.3079  -14.4480
            17  N4x N    13.0454  -13.9571
            18  N5x N    12.1337  -15.0091
            19  C8y C    12.8350  -16.2014
            20  C1a C    15.5002  -13.7467
            21  C1a C    12.2739  -17.5340
            22  X   Cl   25.7600  -18.7600
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 2
            10    2  10 1
            11    1  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 1
            19   18  19 2
            20   15  19 1
            21   16  20 1
            22   19  21 1

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