KEGG   DRUG: Trilaciclib dihydrochloride
Entry
D11987                      Drug                                   
Name
Trilaciclib dihydrochloride;
Cosela (TN)
Product
COSELA (G1 Therapeutics), COSELA (Pharmacosmos Therapeutics)
Formula
C24H30N8O. 2HCl
Exact mass
518.2076
Mol weight
519.47
Structure
Remark
ATC code: V03AF12
Chemical structure group: DG03146
Product (DG03146): D11987<US>
Efficacy
Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor
  Disease
Small cell lung cancer [DS:H00013]
Target
CDK4/6 [HSA:1019 1021] [KO:K02089 K02091]
  Pathway
hsa04110  Cell cycle
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05222  Small cell lung cancer
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AF Detoxifying agents for antineoplastic treatment
     V03AF12 Trilaciclib
      D11987  Trilaciclib dihydrochloride <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastic Adjuncts/Mitigators
   Trilaciclib
    D11987  Trilaciclib dihydrochloride
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CMGC group
    CDK4/6
     D11987  Trilaciclib dihydrochloride <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11987
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11987
Other DBs
PubChem: 497620400
LinkDB
KCF data

ATOM        35
            1   X   Cl   26.7400  -19.5300
            2   C8y C    15.6498  -14.8620
            3   C8y C    15.6498  -16.2638
            4   N5x N    16.9113  -16.9647
            5   C8y C    18.1028  -16.2638
            6   N5x N    18.1028  -14.8620
            7   C8x C    16.9113  -14.1612
            8   N1b N    19.3644  -16.9647
            9   C8y C    20.5558  -16.2638
            10  N5x N    21.7473  -16.9647
            11  C8x C    22.9388  -16.2638
            12  C8y C    22.9388  -14.8620
            13  C8x C    21.7473  -14.1612
            14  C8x C    20.5558  -14.8620
            15  N1y N    24.2003  -14.1612
            16  C1x C    25.3918  -14.8620
            17  C1x C    26.5833  -14.0911
            18  N1y N    26.5833  -12.6894
            19  C1x C    25.3918  -11.9885
            20  C1x C    24.2003  -12.7594
            21  C1a C    27.8449  -11.9885
            22  C8x C    14.3181  -14.4415
            23  C8y C    13.5472  -15.5629
            24  N4y N    14.3181  -16.6843
            25  C5x C    12.1454  -15.7031
            26  N1x N    11.5847  -16.9647
            27  C1x C    12.3557  -18.0860
            28  C1z C    13.7574  -17.9459
            29  C1x C    13.1967  -19.2074
            30  C1x C    14.0378  -20.3288
            31  C1x C    15.4395  -20.1886
            32  C1x C    16.0002  -18.9271
            33  C1x C    15.1592  -17.8057
            34  O5x O    11.3044  -14.5116
            35  X   Cl   26.7400  -19.5300
BOND        38
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14    9  14 1
            15   12  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   15  20 1
            22   18  21 1
            23    2  22 1
            24   22  23 2
            25   23  24 1
            26    3  24 1
            27   23  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   24  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   28  33 1
            38   25  34 2
BRACKET     1    24.9900  -20.3000   24.9900  -18.6900
            1    27.9300  -18.6900   27.9300  -20.3000
            1  2
 ORIGINAL  1    1
 REPEAT    1   35

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