| Entry |
|
|---|
| Name |
Trilaciclib dihydrochloride;
Cosela (TN) |
|---|
| Product |
|
|---|
| Formula |
C24H30N8O. 2HCl
|
|---|
| Exact mass |
518.2076
|
|---|
| Mol weight |
519.4699
|
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| Structure |
|
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| Remark |
| Product (DG03146): | D11987<US> |
|
|---|
| Efficacy |
Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor |
|---|
| Disease |
Small cell lung cancer [DS: H00013] |
|---|
| Target |
|
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| Pathway |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
V VARIOUS
V03 ALL OTHER THERAPEUTIC PRODUCTS
V03A ALL OTHER THERAPEUTIC PRODUCTS
V03AF Detoxifying agents for antineoplastic treatment
V03AF12 Trilaciclib
D11987 Trilaciclib dihydrochloride <US>
Target-based classification of drugs [BR:br08310]
Protein kinases
Serine/threonine kinases
CMGC group
CDK4/6
D11987 Trilaciclib dihydrochloride <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D11987
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D11987
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 35
1 C8y C 22.3300 -13.9300
2 N4y N 22.3300 -15.3300
3 C1z C 23.5200 -16.0300
4 C1x C 24.7800 -15.3300
5 N1x N 24.7800 -13.9300
6 C5x C 23.5200 -13.2300
7 C1x C 22.3300 -16.7300
8 C1x C 22.3300 -18.0600
9 C1x C 23.5200 -18.7600
10 C1x C 24.7800 -18.0600
11 C1x C 24.7800 -16.7300
12 O5x O 23.5200 -11.8300
13 C8x C 21.0000 -13.4400
14 C8y C 20.2300 -14.6300
15 C8y C 21.0000 -15.7500
16 C8x C 18.8300 -14.7700
17 N5x N 18.2700 -16.0300
18 C8y C 19.0400 -17.1500
19 N5x N 20.4400 -17.0100
20 N1b N 18.4800 -18.4800
21 C8y C 17.0800 -18.4800
22 N5x N 16.3800 -17.2200
23 C8x C 14.9800 -17.2200
24 C8y C 14.2800 -18.4800
25 C8x C 14.9800 -19.6700
26 C8x C 16.3800 -19.6700
27 N1y N 12.9500 -18.4800
28 C1x C 12.2500 -17.2200
29 C1x C 10.8500 -17.2200
30 N1y N 10.1500 -18.4100
31 C1x C 10.8500 -19.6700
32 C1x C 12.2500 -19.6700
33 C1a C 8.7500 -18.4100
34 X Cl 26.6000 -19.7400
35 X Cl 26.6000 -19.7400
BOND 38
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 7 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 11 3 1
12 7 3 1
13 6 12 2
14 1 13 2
15 13 14 1
16 14 15 2
17 2 15 1
18 14 16 1
19 16 17 2
20 17 18 1
21 18 19 2
22 15 19 1
23 18 20 1
24 20 21 1
25 21 22 2
26 22 23 1
27 23 24 2
28 24 25 1
29 25 26 2
30 21 26 1
31 24 27 1
32 27 28 1
33 28 29 1
34 29 30 1
35 30 31 1
36 31 32 1
37 27 32 1
38 30 33 1
BRACKET 1 24.8500 -20.5100 24.8500 -18.9000
1 27.7900 -18.9000 27.7900 -20.5100
1 2
ORIGINAL 1 34
REPEAT 1 35
|
|---|
