| Entry |
|
|---|
| Name |
Imlunestrant tosylate (USAN);
Imlunestrant tosilate (JAN);
Inluriyo (TN) |
|---|
| Product |
|
|---|
| Formula |
C29H24F4N2O3. C7H8O3S
|
|---|
| Exact mass |
696.1917
|
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| Mol weight |
696.71
|
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| Structure |
|
|---|
| Class |
|
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| Remark |
| Therapeutic category: | 4291 |
| Product (DG03177): | D12217<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Estrogen receptor antagonist |
|---|
| Disease |
Breast cancer (ER positive, HER2 negative, ESR1 mutated) [DS: H00031] |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Network |
| nt06227 | Nuclear receptor signaling (cancer) |
|
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| Metabolism |
|
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| Interaction |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D12217 Imlunestrant tosylate (USAN); Imlunestrant tosilate (JAN)
Drug groups [BR:br08330]
Antineoplastic
DG01585 Estrogen receptor antagonist
DG03177 Imlunestrant
D12217 Imlunestrant tosylate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03177 Imlunestrant
D12217 Imlunestrant tosylate
DG02924 UGT substrate
DG03183 UGT1A1 substrate
DG03177 Imlunestrant
D12217 Imlunestrant tosylate
DG03184 UGT1A3 substrate
DG03177 Imlunestrant
D12217 Imlunestrant tosylate
DG03186 UGT1A8 substrate
DG03177 Imlunestrant
D12217 Imlunestrant tosylate
DG03188 UGT1A9 substrate
DG03177 Imlunestrant
D12217 Imlunestrant tosylate
Unclassified
DG03375 UGT1A10 substrate
DG03177 Imlunestrant
D12217 Imlunestrant tosylate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
Estrogen receptor
NR3A1 (ESR1)
D12217 Imlunestrant tosylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D12217
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D12217
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D12217
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D12217
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D12217
Pharmacogenomic biomarkers [br08341.html]
Somatic variations in targeted cancer therapies
D12217
Drug groups [BR:br08330]
Antineoplastic
DG01585 Estrogen receptor antagonist
DG03177 Imlunestrant
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03177 Imlunestrant
DG02924 UGT substrate
DG03183 UGT1A1 substrate
DG03177 Imlunestrant
DG03184 UGT1A3 substrate
DG03177 Imlunestrant
DG03186 UGT1A8 substrate
DG03177 Imlunestrant
DG03188 UGT1A9 substrate
DG03177 Imlunestrant
Unclassified
DG03375 UGT1A10 substrate
DG03177 Imlunestrant
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 49
1 C8y C 17.2290 -14.7777
2 C8y C 17.2290 -13.3770
3 N5x N 16.0383 -12.6766
4 C8x C 14.7777 -13.3770
5 C8y C 14.7777 -14.7777
6 C8y C 16.0383 -15.4780
7 C8x C 18.4196 -15.4780
8 C8x C 19.6802 -14.7777
9 C8y C 19.6802 -13.3770
10 C8x C 18.4196 -12.6766
11 O1a O 20.8708 -12.6766
12 C8y C 13.5871 -15.4780
13 C8y C 13.5871 -16.8788
14 O2x O 14.7777 -17.5791
15 C1y C 16.0383 -16.8788
16 C8x C 12.3964 -14.7777
17 C8x C 11.1358 -15.4780
18 C8y C 11.1358 -16.8788
19 C8x C 12.3964 -17.5791
20 C1d C 9.9452 -17.5791
21 X F 8.6845 -18.2795
22 X F 10.6455 -18.7698
23 X F 9.2448 -16.3885
24 C8y C 17.2290 -17.5791
25 C8x C 17.2290 -18.9799
26 C8x C 18.4896 -19.6802
27 C8y C 19.6802 -18.9799
28 C8x C 19.6802 -17.5791
29 C8x C 18.4896 -16.8788
30 O2a O 20.8708 -19.6802
31 C1b C 22.0615 -18.9799
32 C1b C 23.2521 -19.6802
33 N1y N 24.4427 -18.9799
34 C1x C 25.7734 -19.3300
35 C1y C 26.1236 -17.9994
36 C1x C 24.7929 -17.6492
37 C1b C 27.3842 -17.2990
38 X F 28.5749 -17.9994
39 C8x C 30.5900 -16.2400
40 C8x C 30.5900 -17.6400
41 C8y C 31.8024 -18.3400
42 C8x C 33.0149 -17.6400
43 C8x C 33.0149 -16.2400
44 C8y C 31.8024 -15.5400
45 C1a C 31.8024 -19.7398
46 S4a S 31.8024 -14.1402
47 O1d O 30.4024 -14.1402
48 O1d O 33.2024 -14.1402
49 O1d O 31.8024 -12.7402
BOND 54
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 2 10 1
12 9 11 1
13 5 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 6 15 1
18 12 16 2
19 16 17 1
20 17 18 2
21 18 19 1
22 13 19 2
23 18 20 1
24 20 21 1
25 20 22 1
26 20 23 1
27 15 24 1 #Up
28 24 25 2
29 25 26 1
30 26 27 2
31 27 28 1
32 28 29 2
33 24 29 1
34 27 30 1
35 30 31 1
36 31 32 1
37 32 33 1
38 33 34 1
39 34 35 1
40 35 36 1
41 33 36 1
42 35 37 1
43 37 38 1
44 39 40 2
45 40 41 1
46 41 42 2
47 42 43 1
48 43 44 2
49 39 44 1
50 41 45 1
51 44 46 1
52 46 47 2
53 46 48 2
54 46 49 1
|
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