KEGG   DRUG: Nirmatrelvir and ritonavir
Entry
D12269            Mixture   Drug                                   

Name
Nirmatrelvir and ritonavir;
Paxlovid (TN)
Component
Nirmatrelvir [DR:D12244], Ritonavir [DR:D00427]
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Efficacy
Antiviral
  Disease
Coronavirus disease 2019 [DS:H02398]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Brite
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D12269  Nirmatrelvir and ritonavir
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   D12269  Nirmatrelvir and ritonavir
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12269
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12269
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12269
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