KEGG   DRUG: Tovorafenib
Entry
D12291                      Drug                                   
Name
Tovorafenib (USAN/INN);
Ojemda (TN)
Product
OJEMDA (Day One Biopharmaceuticals)
Formula
C17H12Cl2F3N7O2S
Exact mass
505.0102
Mol weight
506.29
Structure
Remark
Product: D12291<US>
Efficacy
Antineoplastic, pan-RAF inhibitor
  Disease
Pediatric low-grade glioma (BRAF fusion or BRAF rearrangement, or BRAF V600 mutation positive) [DS:H00042]
Target
BRAF* [HSA_VAR:673v1 673v2] [HSA:673] [KO:K04365]
RAF1 [HSA:5894] [KO:K04366]
  Pathway
hsa04010  MAPK signaling pathway
hsa04068  FoxO signaling pathway
hsa05200  Pathways in cancer
hsa05214  Glioma
  Network
nt06273  Glioma
Brite
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Multitargeted Kinase Inhibitors, BRAF
    Tovorafenib
     D12291  Tovorafenib (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   TKL group
    BRAF* [HSA_VAR:673v1 673v2]
     D12291  Tovorafenib (USAN/INN) <US>
    RAF1
     D12291  Tovorafenib (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12291
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12291
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D12291
Other DBs
CAS: 1096708-71-2
PubChem: 497620704
PDB-CCD: QOP[PDBj]
LinkDB
KCF data

ATOM        32
            1   C8x C    24.9900  -15.4700
            2   C8y C    24.9900  -16.8700
            3   N5x N    26.1800  -17.5700
            4   C8x C    27.4400  -16.8700
            5   C8y C    27.4400  -15.4700
            6   C8y C    26.1800  -14.7700
            7   C1d C    26.1800  -13.3700
            8   X   F    24.7800  -13.3700
            9   X   F    27.5800  -13.3700
            10  X   F    26.1800  -11.9700
            11  X   Cl   28.6300  -14.7700
            12  N1b N    23.8000  -17.5700
            13  C5a C    22.6100  -16.8700
            14  C8y C    21.4200  -17.5700
            15  O5a O    22.6100  -15.4700
            16  S2x S    20.3000  -16.7300
            17  C8y C    19.1800  -17.5700
            18  N5x N    19.6000  -18.8300
            19  C8x C    20.9300  -18.8300
            20  C1c C    17.9900  -16.8700
            21  N1b N    16.8000  -17.5700
            22  C1a C    17.9900  -15.4700
            23  C5a C    15.5819  -16.8799
            24  C8y C    14.4005  -17.5750
            25  O5a O    15.6402  -15.4706
            26  N5x N    13.1951  -16.8920
            27  C8x C    11.9884  -17.6018
            28  N5x N    11.9997  -19.0018
            29  C8y C    13.2051  -19.6847
            30  C8y C    14.4118  -18.9749
            31  N1a N    13.2166  -21.0699
            32  X   Cl   15.6339  -19.6674
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     7   9 1
            10    7  10 1
            11    5  11 1
            12    2  12 1
            13   12  13 1
            14   13  14 1
            15   13  15 2
            16   14  16 1
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   14  19 2
            21   20  17 1
            22   20  21 1
            23   20  22 1 #Down
            24   21  23 1
            25   23  24 1
            26   23  25 2
            27   24  26 2
            28   26  27 1
            29   27  28 2
            30   28  29 1
            31   29  30 2
            32   24  30 1
            33   29  31 1
            34   30  32 1

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