Entry Name Gene BRAF B-Raf proto-oncogene, serine/threonine kinase [KO:
K04365 ]
Organism hsa_var Human gene variants (Homo sapiens)
Variation Variation Network Element N00013 Mutation-activated BRAF to ERK signaling pathway
N10007 Kinase inhibitor to BRAF mutation
N10008 Kinase inhibitor to MEK downstream of BRAF mutation
Disease Drug target Reference Authors Kondo T, Ezzat S, Asa SL.
Title Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
Journal Reference Authors Li DD, Zhang YF, Xu HX, Zhang XP
Title The role of BRAF in the pathogenesis of thyroid carcinoma.
Journal Front Biosci (Landmark Ed) 20:1068-78 (2015)
DOI:
10.2741/4359 Reference Authors Richtig G, Hoeller C, Kashofer K, Aigelsreiter A, Heinemann A, Kwong LN, Pichler M, Richtig E
Title Beyond the BRAF(V)(600E) hotspot: biology and clinical implications of rare BRAF gene mutations in melanoma patients.
Journal Reference Authors Guadarrama-Orozco JA, Ortega-Gomez A, Ruiz-Garcia EB, Astudillo-de la Vega H, Meneses-Garcia A, Lopez-Camarillo C
Title Braf V600E mutation in melanoma: translational current scenario.
Journal Reference Authors Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, Weber JS, McArthur GA, Hutson TE, Moschos SJ, Flaherty KT, Hersey P, Kefford R, Lawrence D, Puzanov I, Lewis KD, Amaravadi RK, Chmielowski B, Lawrence HJ, Shyr Y, Ye F, Li J, Nolop KB, Lee RJ, Joe AK, Ribas A
Title Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.
Journal LinkDB All DBs
