Entry |
|
Symbol |
RAF1, CMD1NN, CRAF, NS5, Raf-1, c-Raf
|
Name |
(RefSeq) Raf-1 proto-oncogene, serine/threonine kinase
|
KO |
K04366 | RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] |
|
Organism |
|
Pathway |
hsa01521 | EGFR tyrosine kinase inhibitor resistance |
hsa04072 | Phospholipase D signaling pathway |
hsa04270 | Vascular smooth muscle contraction |
hsa04550 | Signaling pathways regulating pluripotency of stem cells |
hsa04613 | Neutrophil extracellular trap formation |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04650 | Natural killer cell mediated cytotoxicity |
hsa04660 | T cell receptor signaling pathway |
hsa04662 | B cell receptor signaling pathway |
hsa04664 | Fc epsilon RI signaling pathway |
hsa04666 | Fc gamma R-mediated phagocytosis |
hsa04810 | Regulation of actin cytoskeleton |
hsa04914 | Progesterone-mediated oocyte maturation |
hsa04919 | Thyroid hormone signaling pathway |
hsa04928 | Parathyroid hormone synthesis, secretion and action |
hsa04935 | Growth hormone synthesis, secretion and action |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
hsa05163 | Human cytomegalovirus infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05170 | Human immunodeficiency virus 1 infection |
hsa05207 | Chemical carcinogenesis - receptor activation |
hsa05208 | Chemical carcinogenesis - reactive oxygen species |
hsa05230 | Central carbon metabolism in cancer |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Network |
|
Element |
N00001 | EGF-EGFR-RAS-ERK signaling pathway |
N00002 | BCR-ABL fusion kinase to RAS-ERK signaling pathway |
N00003 | Mutation-activated KIT to RAS-ERK signaling pathway |
N00004 | Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway |
N00005 | Mutation-activated MET to RAS-ERK signaling pathway |
N00006 | Amplified EGFR to RAS-ERK signaling pathway |
N00007 | EML4-ALK fusion kinase to RAS-ERK signaling pathway |
N00008 | RET fusion kinase to RAS-ERK signaling pathway |
N00009 | TRK fusion kinase to RAS-ERK signaling pathway |
N00011 | Mutation-activated FGFR3 to RAS-ERK signaling pathway |
N00012 | Mutation-activated KRAS/NRAS to ERK signaling pathway |
N00014 | Mutation-activated EGFR to RAS-ERK signaling pathway |
N00015 | PDGF-PDGFR-RAS-ERK signaling pathway |
N00016 | PDGF-overexpression to RAS-ERK signaling pathway |
N00018 | Amplified PDGFR to RAS-ERK signaling pathway |
N00019 | FGF-FGFR-RAS-ERK signaling pathway |
N00020 | Amplified FGFR to RAS-ERK signaling pathway |
N00021 | EGF-ERBB2-RAS-ERK signaling pathway |
N00022 | ERBB2-overexpression to RAS-ERK signaling pathway |
N00023 | EGF-EGFR-PLCG-ERK signaling pathway |
N00024 | Mutation-activated EGFR to PLCG-ERK signaling pathway |
N00025 | EML4-ALK fusion kinase to PLCG-ERK signaling pathway |
N00041 | EGFR-overexpression to RAS-ERK signaling pathway |
N00077 | HRAS-overexpression to ERK signaling pathway |
N00078 | Mutation-activated HRAS to ERK signaling pathway |
N00152 | CXCR-GNB/G-ERK signaling pathway |
N00215 | KITLG-KIT-RAS-ERK signaling pathway |
N00216 | HGF-MET-RAS-ERK signaling pathway |
N00217 | FLT3LG-FLT3-RAS-ERK signaling pathway |
N00229 | TGFA-EGFR-RAS-ERK signaling pathway |
N00230 | TGFA-overexpression to RAS-ERK signaling pathway |
N00233 | IGF-IGF1R-RAS-ERK signaling pathway |
N00235 | IGF2-overexpression to RAS-ERK signaling pathway |
N00237 | IGF1R-overexpression to RAS-ERK signaling pathway |
N00246 | HGF-overexpression to RAS-ERK signaling pathway |
N00248 | MET-overexpression to RAS-ERK signaling pathway |
N00252 | Amplified ERBB2 to RAS-ERK signaling pathway |
N00259 | Amplified MET to RAS-ERK signaling pathway |
N00276 | EGF-overexpression to RAS-ERK signaling pathway |
N00277 | EREG-EGFR-RAS-ERK signaling pathway |
N00278 | EREG-overexpression to RAS-ERK signaling pathway |
N00279 | AREG-EGFR-RAS-ERK signaling pathway |
N00280 | AREG-overexpression to RAS-ERK signaling pathway |
N00367 | HPV E5 to EGFR-RAS-ERK signaling pathway |
N00386 | HCMV gB to PDGFR-RAS-ERK signaling pathway |
N00513 | Mutation-activated EGFR to RAS-ERK signaling pathway |
N00518 | HCV Core to ERK signaling pathway |
N00538 | Ca2+-PYK2-RAS-ERK signaling pathway |
N00540 | HBV HBx to RAS-ERK signaling pathway |
N00546 | CXCL12-CXCR4-PKC-ERK signaling pathaway |
N00744 | IAV HA to ERK signaling pathway |
N00873 | GnRH-GnRHR-PLCB-PKC signaling pathway |
N00994 | AGE-RAGE signaling pathway |
N00996 | Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway |
N01062 | Mutation-activated MET to RAS-ERK signaling pathway |
N01064 | Mutation-activated RET to RAS-ERK signaling pathway |
N01119 | RAC/CDC42-PAK-ERK signaling pathway |
N01336 | CHRNA7-E2F signaling pathway |
N01337 | NNK/NNN to CHRNA7-E2F signaling pathway |
N01343 | ACH-CHRN-RAS-ERK signaling pathway |
N01344 | NNK/NNN to RAS-ERK signaling pathway |
N01351 | E2-ER-RAS-ERK signaling pathway |
N01352 | BPA to RAS-ERK signaling pathway |
N01353 | E2 to RAS-ERK signaling pathway |
N01354 | BPA to RAS-ERK signaling pathway |
N01360 | P4-PR-RAS-ERK signaling pathway |
N01361 | P4/MPA to PR-RAS-ERK signaling pathway |
N01408 | Metals to RAS-ERK signaling pathway |
N01592 | GF-RTK-RAS-ERK signaling pathway |
N01598 | Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase |
N01874 | NRG-ERBB2/ERBB3 pathway (RAS-ERK signaling) |
|
Disease |
H00523 | Noonan syndrome and related disorders |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
5894 (RAF1)
04015 Rap1 signaling pathway
5894 (RAF1)
04630 JAK-STAT signaling pathway
5894 (RAF1)
04068 FoxO signaling pathway
5894 (RAF1)
04072 Phospholipase D signaling pathway
5894 (RAF1)
04071 Sphingolipid signaling pathway
5894 (RAF1)
04024 cAMP signaling pathway
5894 (RAF1)
04022 cGMP-PKG signaling pathway
5894 (RAF1)
04151 PI3K-Akt signaling pathway
5894 (RAF1)
04150 mTOR signaling pathway
5894 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
5894 (RAF1)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
5894 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
5894 (RAF1)
04650 Natural killer cell mediated cytotoxicity
5894 (RAF1)
04660 T cell receptor signaling pathway
5894 (RAF1)
04662 B cell receptor signaling pathway
5894 (RAF1)
04664 Fc epsilon RI signaling pathway
5894 (RAF1)
04666 Fc gamma R-mediated phagocytosis
5894 (RAF1)
04062 Chemokine signaling pathway
5894 (RAF1)
09152 Endocrine system
04929 GnRH secretion
5894 (RAF1)
04915 Estrogen signaling pathway
5894 (RAF1)
04917 Prolactin signaling pathway
5894 (RAF1)
04921 Oxytocin signaling pathway
5894 (RAF1)
04926 Relaxin signaling pathway
5894 (RAF1)
04935 Growth hormone synthesis, secretion and action
5894 (RAF1)
04919 Thyroid hormone signaling pathway
5894 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
5894 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
5894 (RAF1)
04720 Long-term potentiation
5894 (RAF1)
04730 Long-term depression
5894 (RAF1)
04722 Neurotrophin signaling pathway
5894 (RAF1)
09158 Development and regeneration
04360 Axon guidance
5894 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
5894 (RAF1)
05206 MicroRNAs in cancer
5894 (RAF1)
05205 Proteoglycans in cancer
5894 (RAF1)
05207 Chemical carcinogenesis - receptor activation
5894 (RAF1)
05208 Chemical carcinogenesis - reactive oxygen species
5894 (RAF1)
05230 Central carbon metabolism in cancer
5894 (RAF1)
05231 Choline metabolism in cancer
5894 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
5894 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
5894 (RAF1)
05212 Pancreatic cancer
5894 (RAF1)
05225 Hepatocellular carcinoma
5894 (RAF1)
05226 Gastric cancer
5894 (RAF1)
05214 Glioma
5894 (RAF1)
05221 Acute myeloid leukemia
5894 (RAF1)
05220 Chronic myeloid leukemia
5894 (RAF1)
05218 Melanoma
5894 (RAF1)
05211 Renal cell carcinoma
5894 (RAF1)
05219 Bladder cancer
5894 (RAF1)
05215 Prostate cancer
5894 (RAF1)
05213 Endometrial cancer
5894 (RAF1)
05224 Breast cancer
5894 (RAF1)
05223 Non-small cell lung cancer
5894 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
5894 (RAF1)
05161 Hepatitis B
5894 (RAF1)
05160 Hepatitis C
5894 (RAF1)
05164 Influenza A
5894 (RAF1)
05163 Human cytomegalovirus infection
5894 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
5894 (RAF1)
05165 Human papillomavirus infection
5894 (RAF1)
09171 Infectious disease: bacterial
05152 Tuberculosis
5894 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
5894 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
5894 (RAF1)
09165 Substance dependence
05034 Alcoholism
5894 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
5894 (RAF1)
01522 Endocrine resistance
5894 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
5894 (RAF1)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
5894 (RAF1)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: TKL group
RAF family [OT]
5894 (RAF1)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
LinkDB |
|
Position |
3:complement(12583601..12664117)
|
AA seq |
648 aa
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF |
NT seq |
1947 nt +upstreamnt +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaacactatccgtgtt
ttcttgccgaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcgtct
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaacatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacagatattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctctcccagaggcagaggtcgacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacccccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tattgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggtaaatggcacggagatgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccatagagacatgaaatccaacaatatatttctccatgaaggctta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctctggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcggatgtctactcctatggcatcgtattgtatgaa
ctgatgacgggggagcttccttattctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgaggatatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgacc
acgtccccgaggctgcctgtcttctag |