KEGG   DRUG: Acazicolcept
Entry
D12300                      Drug                                   
Name
Acazicolcept (USAN)
Formula
C3578H5518N970O1112S28
Exact mass
80761.7234
Mol weight
80811.7493
Sequence
DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVTYHIP QHSSLEYVDS
RYRNRALMSP AGMLRGDFSL RLFNVTPQDE QKFHCLVLSR SLGFQEVLSV EVTLHVAANF
SVGGGGSGGG GSEPKSSDKT HTCPPCPAPE AEGAPSVFLF PPKPKDTLMI SRTPEVTCVV
VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV
SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES
NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL
SPG
(Disufide bridge: 19-95, 143-143', 146-146', 178-238, 284-342, 19'-95', 178'-238', 284'-342')
  Type
Peptide
Efficacy
Autoimmune disease treatment
Comment
Treatment of systemic lupus erythematosus
Target
ICOS (CD278) [HSA:29851] [KO:K06713]
CD28 [HSA:940] [KO:K06470]
  Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD28
     D12300  Acazicolcept (USAN)
    ICOS (CD278)
     D12300  Acazicolcept (USAN)
Other DBs
CAS: 2270247-50-0
LinkDB

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