KEGG ORTHOLOGY: K06470

ORTHOLOGY: K06470

Entry

K06470                      KO

Symbol

CD28

Name

CD28 antigen

Pathway

map04514

Cell adhesion molecules

map04660

T cell receptor signaling pathway

map04672

Intestinal immune network for IgA production

map04940

Type I diabetes mellitus

map05162

Measles

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05320

Autoimmune thyroid disease

map05322

Systemic lupus erythematosus

map05323

Rheumatoid arthritis

map05330

Allograft rejection

map05332

Graft-versus-host disease

map05416

Viral myocarditis

Disease

H02526

Disorders of adaptive immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06470  CD28; CD28 antigen
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K06470  CD28; CD28 antigen
   04672 Intestinal immune network for IgA production
    K06470  CD28; CD28 antigen
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06470  CD28; CD28 antigen
  09172 Infectious disease: viral
   05162 Measles
    K06470  CD28; CD28 antigen
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06470  CD28; CD28 antigen
   05323 Rheumatoid arthritis
    K06470  CD28; CD28 antigen
   05320 Autoimmune thyroid disease
    K06470  CD28; CD28 antigen
   05330 Allograft rejection
    K06470  CD28; CD28 antigen
   05332 Graft-versus-host disease
    K06470  CD28; CD28 antigen
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06470  CD28; CD28 antigen
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K06470  CD28; CD28 antigen
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06470  CD28; CD28 antigen
CD molecules [BR:ko04090]
Proteins
  K06470  CD28; CD28 antigen (Tp44)

Genes

HSA:

940(CD28)

PTR:	470617(CD28)

PPS:	100992093(CD28)

GGO:	101127818(CD28)

PON:	100450920(CD28)

PPYG:

129032131(CD28)

NLE:	100605914(CD28)

HMH:	116810408(CD28)

SSYN:

129488316(CD28)

MCC:	705313(CD28)

MCF:	102146670(CD28)

MTHB:

126932199

MNI:	105468057(CD28)

CSAB:

103217686(CD28)

CATY:

105580070(CD28)

PANU:

100126740(CD28)

TGE:	112636226(CD28)

MLEU:

105548458(CD28)

RRO:	104653590(CD28)

RBB:	108537220(CD28)

TFN:	117094623(CD28)

PTEH:

111547516(CD28)

CANG:

105517383(CD28)

CJC:	100408536(CD28)

SBQ:	101043195(CD28)

CIMI:

108310125(CD28)

ANAN:

105712901(CD28)

CSYR:

103276858(CD28)

MMUR:

105856925(CD28)

LCAT:

123643862(CD28)

PCOQ:

105819099(CD28)

OGA:	100942667(CD28)

MMU:	12487(Cd28)

MCAL:

110301358(Cd28)

MPAH:

110322470(Cd28)

RNO:	25660(Cd28)

MCOC:

116088494(Cd28)

ANU:	117706160(Cd28)

ASYL:

127692448(Cd28)

MUN:	110554770(Cd28)

CGE:	100769830(Cd28)

MAUA:

101842150(Cd28)

PROB:

127226536(Cd28)

PLEU:

114682485(Cd28)

MORG:

121452787(Cd28)

MFOT:

126508842

AAMP:

119821216(Cd28)

NGI:	103744474(Cd28)

HGL:	101699716(Cd28)

CPOC:

100714966(Cd28)

CCAN:

109694003(Cd28)

DORD:

105981051(Cd28)

DSP:	122096428(Cd28)

PLOP:

125350374(Cd28)

NCAR:

124980653

MMMA:

107138627(Cd28)

ITI:	101966932(Cd28)

OCU:	100008998(CD28)

OPI:	101517944(CD28)

TUP:	102483105(CD28)

GVR:	103605679(CD28)

CFA:	403646(CD28)

CLUD:

112656602(CD28)

VVP:	112922794(CD28)

VLG:	121480715(CD28)

NPO:	129522995(CD28)

AML:	100477902(CD28)

UMR:	103659772(CD28)

UAH:	113250560(CD28)

UAR:	123798321(CD28)

ELK:

111144043

LLV:

125096335

MPUF:

101689176(CD28)

MNP:	132013479(CD28)

MLK:	131827543(CD28)

NVS:	122901713(CD28)

ORO:	101374233(CD28)

EJU:	114215933(CD28)

ZCA:	113920789(CD28)

MLX:	118012117(CD28)

NSU:	110592187(CD28)

LWW:	102736415(CD28)

FCA:	493802(CD28)

PYU:	121030946(CD28)

PCOO:

112872252(CD28)

PBG:	122481673(CD28)

PVIV:

125173472(CD28)

LRUF:

124515009

LGF:	123599345(CD28)

AJU:

106976711

PTG:	102954958(CD28)

PPAD:

109265193(CD28)

PUC:

125911284

PLEZ:

122226523(CD28)

HHV:	120226157(CD28)

BTA:	281050(CD28)

BOM:	102282765(CD28)

BIU:	109569809(CD28)

BBUB:

102400522(CD28)

BBIS:

105003680(CD28)

CHX:	102179142(CD28)

OAS:	443480(CD28)

BTAX:

128060911(CD28)

CSUM:

138076670(CD28)

ODA:	120854591(CD28)

CCAD:

122426779(CD28)

MREE:

136163254(CD28)

MBEZ:

129537909(CD28)

SSC:	100515419(CD28)

CFR:	102507848(CD28)

CBAI:

105082279(CD28)

CDK:	105098982(CD28)

VPC:	102526286(CD28)

BACU:

103017404(CD28)

BMUS:

118898231(CD28)

LVE:	103071468(CD28)

OOR:	101273814(CD28)

LALB:

132521689(CD28)

DLE:	111171754(CD28)

PCAD:

102974216(CD28)

PSIU:

116757116(CD28)

NASI:

112395275(CD28)

ECB:	100067829(CD28)

EPZ:	103557389(CD28)

EAI:	106828142(CD28)

MYB:	102239113(CD28)

MYD:	102773613(CD28)

MMYO:

118662012(CD28)

MLF:	102438564(CD28)

MDT:	132238149(CD28)

MYUM:

139014946(CD28)

PKL:	118709778(CD28)

EFUS:

103290600(CD28)

MNA:	107524832(CD28)

DRO:	112307972(CD28)

SHON:

118985206(CD28)

AJM:	119064348(CD28)

PDIC:

114494613(CD28)

PHAS:

123828916(CD28)

MMF:	118625215(CD28)

PPAM:

129080604(CD28)

HAI:	109393950(CD28)

RFQ:	117026063(CD28)

PALE:

102884019(CD28)

PGIG:

120587556(CD28)

PVP:	105298423(CD28)

RAY:	107519371(CD28)

MJV:	108408617(CD28)

TOD:	119256129(CD28)

SARA:

101543958(CD28)

SFUM:

130021115(CD28)

SETR:

126008669(CD28)

LAV:	100661033(CD28)

TMU:

101343092

ETF:	101643382(CD28)

DNM:	101415501(CD28)

MDO:	100017932(CD28)

GAS:	123241905(CD28)

SHR:	100921336(CD28)

AFZ:

127553204

PCW:	110198515(CD28)

TVP:	118847140(CD28)

PBRV:

138151610(CD28)

OAA:	100082570(CD28)

TACU:

119930857(CD28)

GGA:	396249(CD28)

PCOC:

116234022(CD28)

MGP:	100126555(CD28)

CJO:	107316578(CD28)

TPAI:

128076712(CD28)

LMUT:

125696837(CD28)

NMEL:

110399208(CD28)

APLA:

101803044

ACYG:

106030065(CD28)

CATA:

118259253(CD28)

AFUL:

116490627(CD28)

TGU:	100224836(CD28)

LSR:	110471100(CD28)

SCAN:

103814479(CD28)

PMOA:

120496123(CD28)

OTC:	121335461(CD28)

PRUF:

121356669(CD28)

ATRC:

139593414(CD28)

GFR:	102040186(CD28)

FAB:	101806823(CD28)

OMA:	130255661(CD28)

PHI:	102114220(CD28)

PMAJ:

107207626(CD28)

CCAE:

111932435(CD28)

CCW:	104693812(CD28)

CBRC:

103616526(CD28)

ACOE:

138113346(CD28)

ETL:	114055758(CD28)

ZAB:	102066711(CD28)

ZLE:	135450258(CD28)

ACHL:

103808492(CD28)

SVG:	106855553(CD28)

MMEA:

130577481(CD28)

HRT:	120755254(CD28)

SATI:

136363440(CD28)

CCIC:

134047393(CD28)

FPG:	101923995(CD28)

FCH:	102057651(CD28)

CCRI:

104168410(CD28)

NNT:	104410397(CD28)

SHAB:

115608412(CD28)

ACUN:

113482542(CD28)

TALA:

104365133(CD28)

ACHC:

115343361(CD28)

HALD:

104325825(CD28)

HLE:	104830469(CD28)

AGEN:

126038331

HHAR:

128144569(CD28)

GCL:

127018677

CSTI:

104561092(CD28)

LDI:	104354911(CD28)

MNB:	103771442(CD28)

DPUB:

104296144

PPUS:

135188029(CD28)

AVIT:

104269448(CD28)

BRHI:

104491281(CD28)

EGZ:	104125084(CD28)

NNI:	104010219(CD28)

PCRI:

104036256(CD28)

PCAO:

104043866(CD28)

PADL:

103923718(CD28)

AFOR:

103907284(CD28)

FGA:	104083520(CD28)

GSTE:

104261193(CD28)

CLV:	102087821(CD28)

MUI:	104538334(CD28)

PGUU:

104459947(CD28)

PLET:

104616963(CD28)

EHS:	104509200(CD28)

CMAC:

104482216(CD28)

CUCA:

104058269(CD28)

TEO:	104374830(CD28)

BREG:

104639191(CD28)

OHA:

104339667

ACAR:

104531718(CD28)

CPEA:

104387430(CD28)

CVF:	104291014(CD28)

RTD:	128913057(CD28)

CRID:

134518491(CD28)

AAM:	106492392(CD28)

AROW:

112977199(CD28)

NPD:	112956165(CD28)

TGT:	104573223(CD28)

DNE:	112983980(CD28)

SCAM:

104153003(CD28)

ASN:	102377160(CD28)

AMJ:	102568525(CD28)

CPOO:

109323246(CD28)

GGN:	109302023(CD28)

PSS:	102445987(CD28)

CMY:	102947562(CD28)

CCAY:

125644829(CD28)

DCC:	119863490(CD28)

CPIC:

101945326(CD28)

TST:	117885244(CD28)

CABI:

116817106(CD28)

MRV:	120374238(CD28)

ACS:	100566176(cd28)

ASAO:

132761972(CD28)

PVT:	110090723(CD28)

SUND:

121919548(CD28)

PBI:	112542474(CD28)

PMUR:

107290808(CD28)

CTIG:

120313242(CD28)

TSR:	106549457(CD28)

PGUT:

117675008(CD28)

APRI:

131200207(CD28)

PTEX:

113433880(CD28)

NSS:	113421077(CD28)

VKO:	123024335(CD28)

PMUA:

114585354(CD28)

PRAF:

128402227(CD28)

ZVI:	118093726(CD28)

HCG:	128332227(CD28)

STOW:

125426996(CD28)

EMC:	129324912(CD28)

XLA:	100036969(cd28.L) 108703047(cd28.S)

XTR:	100126210(cd28)

NPR:	108785030(CD28)

RTEM:

120943756(CD28)

BBUF:

121008793

BGAR:

122945333

PWL:	138283474(CD28)

MUO:	115474271(CD28)

DRE:	100151365(si:dkey-1h24.6)

SRX:	107707828 107719745

SANH:

107654253 107705030

SGH:	107556699 107588865

CCAR:

122135845(si:dkey-1h24.6) 122145074

CAUA:

113044379 113056949

CGIB:

127948532(si:dkey-1h24.6) 128015464

PTET:

122348303

LROH:

127172810(si:dkey-1h24.6)

OMC:	131546912(si:dkey-1h24.6)

PPRM:

120468792(si:dkey-1h24.6)

RKG:	130087835(si:dkey-1h24.6)

MAMB:

125272332(si:dkey-1h24.6)

CIDE:

127509289(si:dkey-1h24.6)

CERY:

137032781(si:dkey-1h24.6)

MASI:

127443735(si:dkey-1h24.6)

TROS:

130550444(si:dkey-1h24.6)

TDW:	130409985(si:dkey-1h24.6)

MANU:

129414073(si:dkey-1h24.6)

PDAB:

135753299(si:dkey-1h24.6)

IPU:	108259085(si:dkey-1h24.6)

IFU:	128602421(si:dkey-1h24.6)

PHYP:

113537573

SMEO:

124378127(si:dkey-1h24.6)

TFD:	113648746(si:dkey-1h24.6)

TVC:	132839338(si:dkey-1h24.6)

CGAR:

128506684(si:dkey-1h24.6)

NGRA:

132866718(si:dkey-1h24.6)

TRN:	134329549(si:dkey-1h24.6)

AMEX:

111193547(si:dkey-1h24.6)

CMAO:

118798406(si:dkey-1h24.6)

EEE:

113578513

CHAR:

105911681(si:dkey-1h24.6)

SPIL:

134071166(si:dkey-1h24.6)

TRU:	101079964(cd28)

TFS:	130522188(si:dkey-1h24.6)

NCC:

104945512

CGOB:

115019885

ELY:	117250216(si:dkey-1h24.6)

EFO:	125884948(si:dkey-1h24.6)

PLEP:

121962898

SLUC:

116044787(si:dkey-1h24.6)

ECRA:

117939430(si:dkey-1h24.6) 117953422

ESP:

116674204

PFLV:

114550837

GAT:

120821291

PPUG:

119217105(si:dkey-1h24.6)

MSAM:

119902709(si:dkey-1h24.6)

SCHU:

122872173(si:dkey-1h24.6)

CUD:

121506403

ALAT:

119014946(si:dkey-1h24.6)

MZE:

101482322

ONL:	100699099 109197705

OAU:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

CVG:

GMU:	124861746(si:dkey-1h24.6)

NFU:

107381103

KMR:	108246721(si:dkey-1h24.6)

ALIM:

106510835

NWH:	119429028(si:dkey-1h24.6)

AOCE:

111568749(si:dkey-1h24.6)

MCEP:

125000611

CSEM:

103389879(cd28)

POV:

109642981

SSEN:

122784694(si:dkey-1h24.6)

HHIP:

117777485(si:dkey-1h24.6)

HSP:	118103144(si:dkey-1h24.6)

LCF:

108872968

SDU:

111238728

SLAL:

111644466

XGL:	120798214(si:dkey-1h24.6)

HCQ:	109520852(cd28)

MALB:

109955635

GMH:	115542095(cd28)

SASA:

106574316 106575091(CD28) 106575093(cd28)

STRU:

115179297 115179298 115195937

OTW:	112253921(si:dkey-1h24.6) 121846771

OMY:	100136274 110495954(si:dkey-1h24.6) 110527567 118943619 118964336

OGO:	124008715 124008716 124011219

ONE:	115129622 115134325 115134334

OKI:	109890696 109890697 109906661

OKE:	118363675(si:dkey-1h24.6) 127916654

OMM:	135521340 135542469 135542470 135543606 135547734

OCLA:

139372548 139413105 139414176

SALP:

111953337 111971009 111971010

SNH:	120033504 120033756 120050445(si:dkey-1h24.6)

CCLU:

121554630 121554631 123484614 123484615

ELS:	105023710 105027959 105027960

SFM:	108920653 108942693

PKI:

111840682

AANG:

118222957(si:dkey-1h24.6)

AROT:

135251741(si:dkey-1h24.6)

CCOG:

133124600(si:dkey-1h24.6)

LOC:

107078821

PSPA:

121321600 121323502

ARUT:

117406124 117426134

LCM:	102357005(CD28)

CMK:

103180140

LERI:

129698879 129698880

» show all

Reference

PMID:2825196

Authors

Aruffo A, Seed B

Title

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

Journal

Proc Natl Acad Sci U S A 84:8573-7 (1987)
DOI:10.1073/pnas.84.23.8573

Sequence

[hsa:940]

Reference

PMID:8617933

Authors

Blotta MH, Marshall JD, DeKruyff RH, Umetsu DT

Title

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.

Journal

J Immunol 156:3133-40 (1996)

Reference

PMID:15122199

Authors

Chen L.

Title

Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.

Journal

Nat Rev Immunol 4:336-47 (2004)
DOI:10.1038/nri1349

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