| Entry |
|
|---|
| Name |
Orforglipron (USAN) |
|---|
| Formula |
C48H48F2N10O5
|
|---|
| Exact mass |
882.3777
|
|---|
| Mol weight |
882.95
|
|---|
| Structure |
|
|---|
| Class |
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG03257): | D12529<US> |
|
|---|
| Efficacy |
Antidiabetic, Antiobesity, Glucagon-like peptide 1 (GLP-1) receptor agonist |
|---|
| Comment |
Treatment of hyperglycemia in people with type 2 diabetes; Treatment of obesity
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
DG03257 Orforglipron
D12536 Orforglipron
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03257 Orforglipron
D12536 Orforglipron
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Secretin receptor family
Glucagon
GLP1R
D12536 Orforglipron (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D12536
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
DG03257 Orforglipron
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03257 Orforglipron
|
|---|
| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 65
1 C1x C 17.5639 -14.6861
2 N1y N 17.5639 -16.0915
3 C1y C 18.7585 -16.7942
4 C8y C 20.0233 -16.0915
5 C8y C 20.0233 -14.6861
6 C1x C 18.7585 -13.9834
7 C8y C 21.3584 -16.5131
8 N4y N 22.1313 -15.3888
9 N5x N 21.3584 -14.2645
10 C8y C 23.5367 -15.3888
11 C8x C 24.2394 -16.5834
12 C8y C 25.6448 -16.5834
13 C8y C 26.3475 -15.3888
14 C8y C 25.6448 -14.1942
15 C8x C 24.2394 -14.1942
16 C1a C 26.3475 -12.9997
17 X F 27.7528 -15.3888
18 C1a C 26.3475 -17.7779
19 N4y N 21.7800 -17.8482
20 C8x C 20.9368 -18.9725
21 C8x C 21.7800 -20.0968
22 N4y N 23.1151 -19.6752
23 C8y C 23.1151 -18.2698
24 O5x O 24.2394 -17.4266
25 C8y C 24.2394 -20.5184
26 C8x C 24.2394 -21.9238
27 C8x C 25.4340 -22.6264
28 C8y C 26.6988 -21.9238
29 C8y C 26.6988 -20.5184
30 C8y C 25.4340 -19.8157
31 N4y N 28.0339 -22.3454
32 N5x N 28.8068 -21.2211
33 C8x C 28.0339 -20.0968
34 X F 25.4340 -18.4103
35 C1a C 28.5258 -23.6805
36 C1a C 18.7585 -18.1995
37 C5a C 16.3693 -16.7942
38 C8y C 15.1748 -16.0915
39 O5a O 16.3693 -18.1995
40 C8x C 15.0342 -14.6861
41 C8y C 13.6289 -14.4050
42 C8y C 12.9262 -15.5996
43 N4y N 13.8397 -16.6536
44 C8x C 12.9262 -13.2105
45 C8y C 11.5208 -13.1402
46 C8x C 10.8181 -14.4050
47 C8x C 11.5208 -15.5996
48 C1y C 10.8181 -11.9456
49 C1x C 11.5208 -10.7511
50 C1z C 10.8181 -9.4862
51 O2x O 9.4128 -9.4862
52 C1x C 8.7101 -10.6808
53 C1x C 9.4128 -11.9456
54 C1a C 11.8019 -8.5025
55 C1a C 10.1154 -8.2917
56 C1z C 13.1370 -17.8482
57 C1x C 12.7856 -19.1833
58 C1y C 14.1207 -18.8319
59 C1a C 15.4558 -19.1833
60 C8y C 11.7316 -17.8482
61 N4x N 10.8884 -16.7239
62 C8y C 9.6236 -17.1455
63 O7x O 9.6236 -18.5509
64 N5x N 10.8884 -18.9725
65 O6a O 8.4290 -16.3023
BOND 75
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 2
8 7 8 1
9 8 9 1
10 5 9 2
11 8 10 1
12 10 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 14 15 2
17 10 15 1
18 14 16 1
19 13 17 1
20 12 18 1
21 7 19 1
22 19 20 1
23 20 21 2
24 21 22 1
25 22 23 1
26 19 23 1
27 23 24 2
28 22 25 1
29 25 26 2
30 26 27 1
31 27 28 2
32 28 29 1
33 29 30 2
34 25 30 1
35 28 31 1
36 31 32 1
37 32 33 2
38 29 33 1
39 30 34 1
40 31 35 1
41 3 36 1 #Down
42 2 37 1
43 37 38 1
44 37 39 2
45 38 40 2
46 40 41 1
47 41 42 1
48 42 43 1
49 38 43 1
50 41 44 2
51 44 45 1
52 45 46 2
53 46 47 1
54 42 47 2
55 48 45 1 #Up
56 48 49 1
57 49 50 1
58 50 51 1
59 51 52 1
60 52 53 1
61 48 53 1
62 50 54 1 #Up
63 50 55 1 #Down
64 56 43 1 #Down
65 57 58 1
66 58 56 1
67 56 57 1
68 58 59 1 #Up
69 56 60 1 #Up
70 60 61 1
71 61 62 1
72 62 63 1
73 63 64 1
74 60 64 2
75 62 65 2
|
|---|
